Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-01

AUTHORS

I S Haldorsen, I Stefansson, R Grüner, J A Husby, I J Magnussen, H M J Werner, Ø O Salvesen, L Bjørge, J Trovik, T Taxt, L A Akslen, H B Salvesen

ABSTRACT

BACKGROUND: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) and to explore the potential value of these markers to identify patients with poor outcome. METHODS: In fifty-four surgically staged endometrial carcinoma patients, immunohistochemical staining with factor VIII and Ki67 allowed assessment of microvessel density (MVD) and microvascular proliferation reflecting tumour angiogenesis. In the same patients, preoperative pelvic DCE-MRI and DWI allowed the calculation of parameters describing tumour microvasculature and microstructure in vivo. RESULTS: Microvascular proliferation was negatively correlated to tumour blood flow (Fb) (r=-0.36, P=0.008), capillary permeability surface area product (PS) (r=-0.39, P=0.004) and transfer from the blood to extravascular extracellular space (EES) (Ktrans) (r=-0.40, P=0.003), and was positively correlated to tumour volume (r=0.34; P=0.004). High-tumour microvascular proliferation, low Fb and low Ktrans were all significantly associated with reduced progression/recurrence-free survival (P<0.05). CONCLUSION: Disorganised angiogenesis with coexisting microvascular proliferation and low tumour blood flow is a poor prognostic factor supporting that hypoxia is associated with progression and metastatic spread in endometrial carcinomas. More... »

PAGES

107

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2013.694

DOI

http://dx.doi.org/10.1038/bjc.2013.694

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051489287

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24178757


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293 1] Department of Radiology, Haukeland University Hospital, Jonas Liesvei 65, Postbox 7800, 5021 Bergen, Norway [2] Department of Physics and Technology, University of Bergen, 5020 Bergen, Norway.
294 1] Department of Radiology, Haukeland University Hospital, Jonas Liesvei 65, Postbox 7800, 5021 Bergen, Norway [2] Section for Radiology, Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.
295 Department of Radiology, Haukeland University Hospital, Jonas Liesvei 65, Postbox 7800, 5021 Bergen, Norway.
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.5947.f schema:alternateName Norwegian University of Science and Technology
298 schema:name Unit for applied Clinical Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway.
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.7914.b schema:alternateName University of Bergen
301 schema:name 1] Centre for Cancer Biomarkers, The Gade Institute, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway [2] Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway.
302 rdf:type schema:Organization
 




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