Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10-15

AUTHORS

D N T Aryee, S Niedan, J Ban, R Schwentner, K Muehlbacher, M Kauer, R Kofler, H Kovar

ABSTRACT

Background:Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patients.Methods:PRIMA-1Met, also known as APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. In this study, we interrogated the ability of APR-246 to induce apoptosis and inhibit tumour growth in ES cells with different p53 mutations.Results:APR-246 variably induced apoptosis, associated with Noxa, Puma or p21WAF1 upregulation, in both mutant and wild-type p53 harbouring cells. The apoptosis-inducing capability of APR-246 was markedly reduced in ES cell lines transfected with p53 siRNA. Three ES cell lines established from the same patient at different stages of the disease and two cell lines of different patients with identical p53 mutations all exhibited different sensitivities to APR-246, indicating cellular context dependency. Comparative transcriptome analysis on the three cell lines established from the same patient identified differential expression levels of several TP53 and apoptosis-associated genes such as APOL6, PENK, PCDH7 and MST4 in the APR-246-sensitive cell line relative to the less APR-246-sensitive cell lines.Conclusion:This is the first study reporting the biological response of Ewing sarcoma cells to APR-246 exposure and shows gross variability in responses. Our study also proposes candidate genes whose expression might be associated with ES cells’ sensitivity to APR-246. With APR-246 currently in early-phase clinical trials, our findings call for caution in considering it as a potential adjuvant to conventional ES-specific chemotherapeutics. More... »

PAGES

2696-2704

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2013.635

DOI

http://dx.doi.org/10.1038/bjc.2013.635

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005459369

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24129240


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91 mutant p53
92 mutations
93 novel treatment strategies
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102 reactivation
103 response
104 same patient
105 sarcoma
106 sarcoma cells
107 sensitivity
108 siRNA
109 small organic molecules
110 stage
111 strategies
112 strong indication
113 study
114 subset
115 transcriptome analysis
116 treatment strategies
117 trials
118 tumor cells
119 tumor form
120 tumor growth
121 tumor suppressor function
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