Sarcopenia and body mass index predict sunitinib-induced early dose-limiting toxicities in renal cancer patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03

AUTHORS

O Huillard, O Mir, M Peyromaure, C Tlemsani, J Giroux, P Boudou-Rouquette, S Ropert, N Barry Delongchamps, M Zerbib, F Goldwasser

ABSTRACT

BACKGROUND: Little is known on factors predicting sunitinib toxicity. Recently, the condition of low muscle mass, named sarcopenia, was identified as a significant predictor of toxicity in metastatic renal cell cancer (mRCC) patients treated with sorafenib. We investigated whether sarcopenia could predict early dose-limiting toxicities (DLTs) occurrence in mRCC patients treated with sunitinib. METHODS: Consecutive mRCC patients treated with sunitinib were retrospectively reviewed. A DLT was defined as any toxicity leading to dose reduction or treatment discontinuation. Body composition was evaluated using CT scan obtained within 1 month before treatment initiation. RESULTS: Among 61 patients eligible for analysis, 52.5% were sarcopenic and 32.8% had both sarcopenia and a body mass index (BMI)<25 kg m(-2). Eighteen patients (29.5%) experienced a DLT during the first cycle. Sarcopenic patients with a BMI<25 kg m(-2) experienced more DLTs (P=0.01; odds ratio=4.1; 95% CI: (1.3-13.3)), more cumulative grade 2 or 3 toxicities (P=0.008), more grade 3 toxicities (P=0.04) and more acute vascular toxicities (P=0.009). CONCLUSION: Patients with sarcopenia and a BMI<25 kg m(-2) experienced significantly more DLTs during the first cycle of treatment. More... »

PAGES

1034

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2013.58

DOI

http://dx.doi.org/10.1038/bjc.2013.58

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000012185

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23462722


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