An external validation study of nomograms designed to predict isolated loco-regional and distant endometrial cancer recurrences: how applicable are they? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

AUTHORS

S Bendifallah, G Canlorbe, E Raimond, L Bazire, F Huguet, O Graesslin, R Rouzier, E Darai, M Ballester

ABSTRACT

BACKGROUND: To externally validate and assess the robustness of two nomograms to predict the recurrence risk of women with endometrial cancer (EC). METHODS: Using an independent, multicentre external patient cohort we assessed the discrimination and calibration of two nomograms--the 3-year isolated loco-regional (ILRR) and distant (DR) recurrence nomograms--in women with surgically treated stage I-III EC. RESULTS: Two hundred and seventy one eligible women were identified from two university hospital databases and the Senti-Endo trial. The median follow-up and initial recurrence time were 38.1 (range: 12-69) and 22.0 (range: 8.3-55) months, respectively. The overall recurrence rate was 13.8% (37 out of 271). Predictive accuracy according to the discrimination was 0.69 (95% CI, 0.58-0.79) and 0.66 (95% CI, 0.60-0.71) for the 3-year ILRR and DR nomograms, respectively. The correspondence between observed recurrence rate and the nomogram predictions suggests a moderate calibration of the nomograms in the validation cohort. CONCLUSION: The nomograms were externally validated and shown to be partly generalisable to a new and independent patient population. The tools need to be improved by including information on the lymph node status and adjuvant therapies. More... »

PAGES

1498

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2013.500

DOI

http://dx.doi.org/10.1038/bjc.2013.500

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004130231

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23989946


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