Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06-25

AUTHORS

S Kitada, S Yamada, A Kuma, S Ouchi, T Tasaki, A Nabeshima, H Noguchi, K-Y Wang, S Shimajiri, R Nakano, H Izumi, K Kohno, T Matsumoto, Y Sasaguri

ABSTRACT

BACKGROUND: The polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) family of enzymes regulates the initial steps of mucin-type O-glycosylation. N-acetylgalactosaminyltransferases might show novel patterns of GalNAc-T glycosylation on tumour-derived proteins, which could influence cancer biology, but its mechanisms are unclear. We investigated the association of GalNAc-T3 and -T6 expressions with clinicopathological features and prognoses of patients with renal cell carcinomas (RCCs). METHODS: Expressions of GalNAc-T3/6 and cell-adhesion molecules were analysed immunohistochemically in 254 paraffin-embedded tumour samples of patients with RCC. RESULTS: Of 138 GalNAc-T3+ cases, 46 revealed significant co-expression with GalNAc-T6. N-acetylgalactosaminyltransferases-3+ expression showed a close relationship to poor clinical performance and large tumour size, or pathologically high Fuhrman's grading, and presence of vascular invasion and necrosis. The GalNAc-T3-positivity potentially suppressed adhesive effects with a significantly low β-catenin expression. Univariate and multivariate analyses showed the GalNAc-T3+ group, but not the GalNAc-T6+ group, to have significantly worse survival rates. CONCLUSION: N-acetylgalactosaminyltransferases-3 expression independently predicts high-grade tumour and poor prognosis in patients with RCC, and may offer a therapeutic target against RCC. More... »

PAGES

472-481

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2013.331

DOI

http://dx.doi.org/10.1038/bjc.2013.331

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014800721

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23799843


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29 schema:description BACKGROUND: The polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) family of enzymes regulates the initial steps of mucin-type O-glycosylation. N-acetylgalactosaminyltransferases might show novel patterns of GalNAc-T glycosylation on tumour-derived proteins, which could influence cancer biology, but its mechanisms are unclear. We investigated the association of GalNAc-T3 and -T6 expressions with clinicopathological features and prognoses of patients with renal cell carcinomas (RCCs). METHODS: Expressions of GalNAc-T3/6 and cell-adhesion molecules were analysed immunohistochemically in 254 paraffin-embedded tumour samples of patients with RCC. RESULTS: Of 138 GalNAc-T3+ cases, 46 revealed significant co-expression with GalNAc-T6. N-acetylgalactosaminyltransferases-3+ expression showed a close relationship to poor clinical performance and large tumour size, or pathologically high Fuhrman's grading, and presence of vascular invasion and necrosis. The GalNAc-T3-positivity potentially suppressed adhesive effects with a significantly low β-catenin expression. Univariate and multivariate analyses showed the GalNAc-T3+ group, but not the GalNAc-T6+ group, to have significantly worse survival rates. CONCLUSION: N-acetylgalactosaminyltransferases-3 expression independently predicts high-grade tumour and poor prognosis in patients with RCC, and may offer a therapeutic target against RCC.
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37 GalNAc
38 GalNAc-T3
39 GalNAc-T3/6
40 GalNAc-T6
41 T6 expression
42 acetylgalactosaminyl transferase-3
43 acetylgalactosaminyltransferases
44 acetylgalactosaminyltransferases (GalNAc-Ts) family
45 acetylgalactosaminyltransferases-3 expression
46 adhesive effect
47 analysis
48 association
49 biology
50 cancer biology
51 carcinoma
52 cases
53 catenin expression
54 cell adhesion molecule
55 cell carcinoma
56 clinical performance
57 clinicopathological features
58 close relationship
59 effect
60 enzyme
61 expression
62 family
63 features
64 glycosylation
65 grading
66 group
67 high Fuhrman's grading
68 high-grade tumors
69 initial step
70 invasion
71 larger tumor size
72 mechanism
73 molecules
74 mucin-type O
75 multivariate analysis
76 necrosis
77 novel pattern
78 paraffin-embedded tumor samples
79 patients
80 patterns
81 performance
82 poor clinical performance
83 poor prognosis
84 presence
85 prognosis
86 prognosis of patients
87 protein
88 rate
89 relationship
90 renal cell carcinoma
91 samples
92 size
93 step
94 survival rate
95 target
96 therapeutic target
97 transferase 3
98 tumor samples
99 tumor size
100 tumor-derived proteins
101 tumors
102 vascular invasion
103 worse survival rate
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