Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer View Full Text


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Article Info

DATE

2013-04

AUTHORS

S A Quezada, K S Peggs

ABSTRACT

The past few years have witnessed something of a renaissance in the field of cancer immunotherapy, relating largely to the clinical advances that have been associated with the development of monoclonal antibodies targeting the immune inhibitory co-receptors CTLA-4 and PD-1 and to the pursuit of genetically modified antigen-redirected adoptive T-cell therapies. These advances are based on a more substantial understanding of the factors restricting effective immune therapies that has been derived from the study of pre-clinical models of tumour growth in immune competent mice. Just as the recognition of the importance of positive co-stimulatory signaling has been instrumental to recent advances in the development of genetically modified antigen-specific adoptive cellular therapies, an increasing awareness of the ability of tumours to subvert multiple immune inhibitory pathways, effectively blunting the development or expansion of any anti-tumour immunity, is fostering the development of novel therapies that appear active as monotherapies but may achieve their greatest impact in combinatorial regimens. This mini-review will focus on attempts to target co-inhibitory members of the immunoglobulin superfamily. More... »

PAGES

1560

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2013.117

DOI

http://dx.doi.org/10.1038/bjc.2013.117

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23511566


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