Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04

AUTHORS

S Bellone, D Roque, E Cocco, S Gasparrini, I Bortolomai, N Buza, M Abu-Khalaf, D-A Silasi, E Ratner, M Azodi, P E Schwartz, T J Rutherford, S Pecorelli, A D Santin

ABSTRACT

BACKGROUND: We evaluated the expression of CD46, CD55 and CD59 membrane-bound complement-regulatory proteins (mCRPs) in primary uterine serous carcinoma (USC) and the ability of small interfering RNA (siRNA) against these mCRPs to sensitise USC to complement-dependent cytotoxicity (CDC) and antibody (trastuzumab)-dependent cellular cytotoxicity (ADCC) in vitro. METHODS: Membrane-bound complement-regulatory proteins expression was evaluated using real-time PCR (RT-PCR) and flow cytometry, whereas Her2/neu expression and c-erbB2 gene amplification were assessed using immunohistochemistry, flow cytometry and fluorescent in-situ hybridisation. The biological effect of siRNA-mediated knockdown of mCRPs on HER2/neu-overexpressing USC cell lines was evaluated in CDC and ADCC 4-h chromium-release assays. RESULTS: High expression of mCRPs was found in USC cell lines when compared with normal endometrial cells (P<0.05). RT-PCR and FACS analyses demonstrated that anti-mCRP siRNAs were effective in reducing CD46, CD55 and CD59 expression on USC (P<0.05). Baseline complement-dependent cytotoxicity (CDC) against USC cell lines was low (mean ± s.e.m.=6.8 ± 0.9%) but significantly increased upon CD55 and CD59 knockdown (11.6 ± 0.8% and 10.7 ± 0.9%, respectively, P<0.05). Importantly, in the absence of complement, both CD55 and CD59, but not CD46, knockdowns significantly augmented ADCC against USC overexpressing Her2/neu. CONCLUSION: Uterine serous carcinoma express high levels of the mCRPs CD46, CD55 and CD59. Small interfering RNA inhibition of CD55 and CD59, but not CD46, sensitises USC to both CDC and ADCC in vitro, and if specifically targeted to tumour cells, may significantly increase trastuzumab-mediated therapeutic effect in vivo. More... »

PAGES

1543

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2012.132

DOI

http://dx.doi.org/10.1038/bjc.2012.132

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049022615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22531721


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody-Dependent Cell Cytotoxicity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD55 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD59 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystadenocarcinoma, Serous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytotoxicity, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Cofactor Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trastuzumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Cervical Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bellone", 
        "givenName": "S", 
        "id": "sg:person.01244366775.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366775.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roque", 
        "givenName": "D", 
        "id": "sg:person.0714672065.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714672065.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cocco", 
        "givenName": "E", 
        "id": "sg:person.01364015242.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364015242.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gasparrini", 
        "givenName": "S", 
        "id": "sg:person.0760064771.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760064771.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bortolomai", 
        "givenName": "I", 
        "id": "sg:person.0734604232.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734604232.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Pathology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buza", 
        "givenName": "N", 
        "id": "sg:person.01264655440.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264655440.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine and Oncology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abu-Khalaf", 
        "givenName": "M", 
        "id": "sg:person.01141233371.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141233371.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silasi", 
        "givenName": "D-A", 
        "id": "sg:person.0743746452.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743746452.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ratner", 
        "givenName": "E", 
        "id": "sg:person.01071066142.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071066142.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azodi", 
        "givenName": "M", 
        "id": "sg:person.01163412706.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163412706.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "P E", 
        "id": "sg:person.01207015645.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207015645.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rutherford", 
        "givenName": "T J", 
        "id": "sg:person.01017553075.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017553075.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Brescia", 
          "id": "https://www.grid.ac/institutes/grid.7637.5", 
          "name": [
            "Division of Gynecologic Oncology, University of Brescia, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pecorelli", 
        "givenName": "S", 
        "id": "sg:person.01065666275.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065666275.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santin", 
        "givenName": "A D", 
        "id": "sg:person.01134001475.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134001475.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/74704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000366392", 
          "https://doi.org/10.1038/74704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000366392", 
          "https://doi.org/10.1038/74704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(99)01537-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000751165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1525-1438.2006.00664.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010580997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199608293350907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010589799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011011108", 
          "https://doi.org/10.1038/sj.bjc.6605448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011011108", 
          "https://doi.org/10.1038/sj.bjc.6605448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/era.11.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012117858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-8258(83)90111-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012264639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cco.0000239890.36408.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012774132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cco.0000239890.36408.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012774132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012893426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2009.05.222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014997867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2011.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016178578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019405939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.4827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023211514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-1811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025092386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027689264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027689264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.03.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030768836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.03.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030768836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200103153441101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031768583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032384183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2007.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034179467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036554402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036554402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0041-1345(02)03834-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038792395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijgo.2008.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039812231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2004.10.605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040419430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198203000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044024467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198203000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044024467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-007-0984-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048798976", 
          "https://doi.org/10.1007/s00253-007-0984-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-007-0984-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048798976", 
          "https://doi.org/10.1007/s00253-007-0984-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2004.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051532365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v100.9.3304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053408015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35052073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053565592", 
          "https://doi.org/10.1038/35052073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35052073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053565592", 
          "https://doi.org/10.1038/35052073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35052073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053565592", 
          "https://doi.org/10.1038/35052073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-006-9180-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053715955", 
          "https://doi.org/10.1007/s11095-006-9180-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14712598.5.12.1593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067589586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075051019", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076034949", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076911441", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082695615", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082776006", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-04", 
    "datePublishedReg": "2012-04-01", 
    "description": "BACKGROUND: We evaluated the expression of CD46, CD55 and CD59 membrane-bound complement-regulatory proteins (mCRPs) in primary uterine serous carcinoma (USC) and the ability of small interfering RNA (siRNA) against these mCRPs to sensitise USC to complement-dependent cytotoxicity (CDC) and antibody (trastuzumab)-dependent cellular cytotoxicity (ADCC) in vitro.\nMETHODS: Membrane-bound complement-regulatory proteins expression was evaluated using real-time PCR (RT-PCR) and flow cytometry, whereas Her2/neu expression and c-erbB2 gene amplification were assessed using immunohistochemistry, flow cytometry and fluorescent in-situ hybridisation. The biological effect of siRNA-mediated knockdown of mCRPs on HER2/neu-overexpressing USC cell lines was evaluated in CDC and ADCC 4-h chromium-release assays.\nRESULTS: High expression of mCRPs was found in USC cell lines when compared with normal endometrial cells (P<0.05). RT-PCR and FACS analyses demonstrated that anti-mCRP siRNAs were effective in reducing CD46, CD55 and CD59 expression on USC (P<0.05). Baseline complement-dependent cytotoxicity (CDC) against USC cell lines was low (mean \u00b1 s.e.m.=6.8 \u00b1 0.9%) but significantly increased upon CD55 and CD59 knockdown (11.6 \u00b1 0.8% and 10.7 \u00b1 0.9%, respectively, P<0.05). Importantly, in the absence of complement, both CD55 and CD59, but not CD46, knockdowns significantly augmented ADCC against USC overexpressing Her2/neu.\nCONCLUSION: Uterine serous carcinoma express high levels of the mCRPs CD46, CD55 and CD59. Small interfering RNA inhibition of CD55 and CD59, but not CD46, sensitises USC to both CDC and ADCC in vitro, and if specifically targeted to tumour cells, may significantly increase trastuzumab-mediated therapeutic effect in vivo.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2012.132", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2478916", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2481110", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438823", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "106"
      }
    ], 
    "name": "Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy", 
    "pagination": "1543", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e989157ced5e003099b6ef29b13c19cff7c4642d75e1ad281b6d698f85c46184"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22531721"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2012.132"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049022615"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2012.132", 
      "https://app.dimensions.ai/details/publication/pub.1049022615"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2012132"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2012.132'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2012.132'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2012.132'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2012.132'


 

This table displays all metadata directly associated to this object as RDF triples.

368 TRIPLES      21 PREDICATES      87 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2012.132 schema:about N0272bd49848b4df98e1c042a0a80b9a0
2 N0c34c7658362428bbdbdf9d4ee83557b
3 N114f74f17dcb4b0ca6ca79904fa51888
4 N129033904b9b480787441bb18a866035
5 N1b3a708a9802449ab32fb5c924beae3d
6 N21c48e13987542a3a13efc872201dd5d
7 N2264ccd4ea32435fab96d1d1560008e0
8 N3f625889c2b94ba0921c3a4c84f236c9
9 N5384ac9d9619433b89ef5b5c771c92f9
10 N5d45da9f71714074932aa92664829f72
11 N6bfbe310bfd74e8ab208f9eede1bee19
12 N6dc0b5d385bd409fa63e3f74a68e4428
13 N7100e089ef8f49c5bd706f6910b32eb8
14 N7863849abe84451eb7d2cdb396f64e25
15 N7b635a33a4ca42d4b17c079d46085d37
16 N7ce7594d6a2243dbbf4ad9c69b94e73a
17 N808bb4d97e7a40b2a73834e13830bdf9
18 N995e4b061fc84cdb9a29e3e6f3c8d196
19 Nafe91e1873364c5fb8ca55b460852e98
20 Nc06e4919ec7247068c72576ca47a80a4
21 Ncb8037383e624b26b6bf4135459a6e00
22 Ne5f6a08b424c4deeb62d4cd50ec10aae
23 Nee14a213bd8644a19c52160b67bf8834
24 anzsrc-for:06
25 anzsrc-for:0601
26 schema:author N674194899db045229d162631c439dbe0
27 schema:citation sg:pub.10.1007/s00253-007-0984-y
28 sg:pub.10.1007/s11095-006-9180-5
29 sg:pub.10.1038/35052073
30 sg:pub.10.1038/74704
31 sg:pub.10.1038/sj.bjc.6605448
32 https://app.dimensions.ai/details/publication/pub.1075051019
33 https://app.dimensions.ai/details/publication/pub.1076034949
34 https://app.dimensions.ai/details/publication/pub.1076911441
35 https://app.dimensions.ai/details/publication/pub.1082695615
36 https://app.dimensions.ai/details/publication/pub.1082776006
37 https://doi.org/10.1002/cncr.21308
38 https://doi.org/10.1016/0090-8258(83)90111-7
39 https://doi.org/10.1016/j.ajog.2004.10.605
40 https://doi.org/10.1016/j.ijgo.2008.04.008
41 https://doi.org/10.1016/j.it.2004.01.008
42 https://doi.org/10.1016/j.molimm.2009.05.222
43 https://doi.org/10.1016/j.ygyno.2005.03.041
44 https://doi.org/10.1016/j.ygyno.2005.08.017
45 https://doi.org/10.1016/j.ygyno.2007.09.007
46 https://doi.org/10.1016/j.ygyno.2011.10.009
47 https://doi.org/10.1016/s0041-1345(02)03834-4
48 https://doi.org/10.1016/s0167-5699(99)01537-6
49 https://doi.org/10.1056/nejm199608293350907
50 https://doi.org/10.1056/nejm200103153441101
51 https://doi.org/10.1097/00000478-198203000-00002
52 https://doi.org/10.1097/01.cco.0000239890.36408.75
53 https://doi.org/10.1111/j.1525-1438.2006.00664.x
54 https://doi.org/10.1158/0008-5472.can-05-3191
55 https://doi.org/10.1158/0008-5472.can-07-1811
56 https://doi.org/10.1182/blood.v100.9.3304
57 https://doi.org/10.1200/jco.2005.01.014
58 https://doi.org/10.1200/jco.2005.03.4827
59 https://doi.org/10.1517/14712598.5.12.1593
60 https://doi.org/10.1586/era.11.192
61 https://doi.org/10.3322/caac.20121
62 schema:datePublished 2012-04
63 schema:datePublishedReg 2012-04-01
64 schema:description BACKGROUND: We evaluated the expression of CD46, CD55 and CD59 membrane-bound complement-regulatory proteins (mCRPs) in primary uterine serous carcinoma (USC) and the ability of small interfering RNA (siRNA) against these mCRPs to sensitise USC to complement-dependent cytotoxicity (CDC) and antibody (trastuzumab)-dependent cellular cytotoxicity (ADCC) in vitro. METHODS: Membrane-bound complement-regulatory proteins expression was evaluated using real-time PCR (RT-PCR) and flow cytometry, whereas Her2/neu expression and c-erbB2 gene amplification were assessed using immunohistochemistry, flow cytometry and fluorescent in-situ hybridisation. The biological effect of siRNA-mediated knockdown of mCRPs on HER2/neu-overexpressing USC cell lines was evaluated in CDC and ADCC 4-h chromium-release assays. RESULTS: High expression of mCRPs was found in USC cell lines when compared with normal endometrial cells (P<0.05). RT-PCR and FACS analyses demonstrated that anti-mCRP siRNAs were effective in reducing CD46, CD55 and CD59 expression on USC (P<0.05). Baseline complement-dependent cytotoxicity (CDC) against USC cell lines was low (mean ± s.e.m.=6.8 ± 0.9%) but significantly increased upon CD55 and CD59 knockdown (11.6 ± 0.8% and 10.7 ± 0.9%, respectively, P<0.05). Importantly, in the absence of complement, both CD55 and CD59, but not CD46, knockdowns significantly augmented ADCC against USC overexpressing Her2/neu. CONCLUSION: Uterine serous carcinoma express high levels of the mCRPs CD46, CD55 and CD59. Small interfering RNA inhibition of CD55 and CD59, but not CD46, sensitises USC to both CDC and ADCC in vitro, and if specifically targeted to tumour cells, may significantly increase trastuzumab-mediated therapeutic effect in vivo.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N83e11f2ffcc2460ab6781f36502c1501
69 N9f5202243607494d8fe8e19759d7daef
70 sg:journal.1017082
71 schema:name Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy
72 schema:pagination 1543
73 schema:productId N112a7c7336db40b2a7251b5d4ad50e33
74 N1884185cd1d244eaa8e474a56142a0a2
75 N7269e4bb29544823b3dc4f5dab803feb
76 N921e33090064427ba8b80e2b95b5ec4f
77 Nacdd0aa3591745f8a6ae40a8d47b4874
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049022615
79 https://doi.org/10.1038/bjc.2012.132
80 schema:sdDatePublished 2019-04-11T01:14
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N99dbb4f8840f4b5f8ef5bb66d7276f72
83 schema:url https://www.nature.com/articles/bjc2012132
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0272bd49848b4df98e1c042a0a80b9a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Antibodies, Monoclonal, Humanized
89 rdf:type schema:DefinedTerm
90 N0c34c7658362428bbdbdf9d4ee83557b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name CD55 Antigens
92 rdf:type schema:DefinedTerm
93 N112a7c7336db40b2a7251b5d4ad50e33 schema:name dimensions_id
94 schema:value pub.1049022615
95 rdf:type schema:PropertyValue
96 N114f74f17dcb4b0ca6ca79904fa51888 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Female
98 rdf:type schema:DefinedTerm
99 N129033904b9b480787441bb18a866035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Membrane Cofactor Protein
101 rdf:type schema:DefinedTerm
102 N1884185cd1d244eaa8e474a56142a0a2 schema:name pubmed_id
103 schema:value 22531721
104 rdf:type schema:PropertyValue
105 N1a12d397310b49d9914a6e4d187e1e97 rdf:first sg:person.0714672065.28
106 rdf:rest N283f226e6e4d443696e91f7fd6015912
107 N1b3a708a9802449ab32fb5c924beae3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Middle Aged
109 rdf:type schema:DefinedTerm
110 N1daef26cd9ab4de7813cd3fa8e29e0fe rdf:first sg:person.01017553075.00
111 rdf:rest Nbfafdac082654a2092449eef937be727
112 N21c48e13987542a3a13efc872201dd5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Uterine Cervical Neoplasms
114 rdf:type schema:DefinedTerm
115 N2264ccd4ea32435fab96d1d1560008e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Receptor, ErbB-2
117 rdf:type schema:DefinedTerm
118 N226babb7de5b4927a6b46ee16eec9d80 rdf:first sg:person.0734604232.35
119 rdf:rest N2efebd84fcff4246a5f30ce8d54b0a79
120 N283f226e6e4d443696e91f7fd6015912 rdf:first sg:person.01364015242.73
121 rdf:rest Nfb4a350df30646d39609d67fd8119d1e
122 N2dae8e04119c4c1ea7c56aefa72af9f7 rdf:first sg:person.01071066142.74
123 rdf:rest Nd0e3ff7125244c5888e4a127db3f8462
124 N2efebd84fcff4246a5f30ce8d54b0a79 rdf:first sg:person.01264655440.98
125 rdf:rest Ndf9bd4c6e4ea4c9b851311df18c4236a
126 N3f625889c2b94ba0921c3a4c84f236c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Prognosis
128 rdf:type schema:DefinedTerm
129 N5384ac9d9619433b89ef5b5c771c92f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Antibodies, Monoclonal
131 rdf:type schema:DefinedTerm
132 N5d45da9f71714074932aa92664829f72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name RNA, Small Interfering
134 rdf:type schema:DefinedTerm
135 N674194899db045229d162631c439dbe0 rdf:first sg:person.01244366775.56
136 rdf:rest N1a12d397310b49d9914a6e4d187e1e97
137 N6bfbe310bfd74e8ab208f9eede1bee19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Flow Cytometry
139 rdf:type schema:DefinedTerm
140 N6dc0b5d385bd409fa63e3f74a68e4428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name In Situ Hybridization, Fluorescence
142 rdf:type schema:DefinedTerm
143 N7100e089ef8f49c5bd706f6910b32eb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Antibody-Dependent Cell Cytotoxicity
145 rdf:type schema:DefinedTerm
146 N7269e4bb29544823b3dc4f5dab803feb schema:name doi
147 schema:value 10.1038/bjc.2012.132
148 rdf:type schema:PropertyValue
149 N7863849abe84451eb7d2cdb396f64e25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Down-Regulation
151 rdf:type schema:DefinedTerm
152 N7b635a33a4ca42d4b17c079d46085d37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cystadenocarcinoma, Serous
154 rdf:type schema:DefinedTerm
155 N7ce7594d6a2243dbbf4ad9c69b94e73a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Complement Activation
157 rdf:type schema:DefinedTerm
158 N808bb4d97e7a40b2a73834e13830bdf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name CD59 Antigens
160 rdf:type schema:DefinedTerm
161 N82d2a812341941afadaf17c2dc3e6b8e rdf:first sg:person.0743746452.51
162 rdf:rest N2dae8e04119c4c1ea7c56aefa72af9f7
163 N83e11f2ffcc2460ab6781f36502c1501 schema:issueNumber 9
164 rdf:type schema:PublicationIssue
165 N921e33090064427ba8b80e2b95b5ec4f schema:name readcube_id
166 schema:value e989157ced5e003099b6ef29b13c19cff7c4642d75e1ad281b6d698f85c46184
167 rdf:type schema:PropertyValue
168 N995e4b061fc84cdb9a29e3e6f3c8d196 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cytotoxicity, Immunologic
170 rdf:type schema:DefinedTerm
171 N99dbb4f8840f4b5f8ef5bb66d7276f72 schema:name Springer Nature - SN SciGraph project
172 rdf:type schema:Organization
173 N9f5202243607494d8fe8e19759d7daef schema:volumeNumber 106
174 rdf:type schema:PublicationVolume
175 Nacdd0aa3591745f8a6ae40a8d47b4874 schema:name nlm_unique_id
176 schema:value 0370635
177 rdf:type schema:PropertyValue
178 Nafe91e1873364c5fb8ca55b460852e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Real-Time Polymerase Chain Reaction
180 rdf:type schema:DefinedTerm
181 Nbfafdac082654a2092449eef937be727 rdf:first sg:person.01065666275.46
182 rdf:rest Nc5712cea9b4d4789b7f2c69d3a36a22f
183 Nc06e4919ec7247068c72576ca47a80a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Aged
185 rdf:type schema:DefinedTerm
186 Nc5712cea9b4d4789b7f2c69d3a36a22f rdf:first sg:person.01134001475.57
187 rdf:rest rdf:nil
188 Ncb8037383e624b26b6bf4135459a6e00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Humans
190 rdf:type schema:DefinedTerm
191 Ncdf0ad9b002a4fb39fcf165303d10d4b rdf:first sg:person.01207015645.37
192 rdf:rest N1daef26cd9ab4de7813cd3fa8e29e0fe
193 Nd0e3ff7125244c5888e4a127db3f8462 rdf:first sg:person.01163412706.67
194 rdf:rest Ncdf0ad9b002a4fb39fcf165303d10d4b
195 Ndf9bd4c6e4ea4c9b851311df18c4236a rdf:first sg:person.01141233371.32
196 rdf:rest N82d2a812341941afadaf17c2dc3e6b8e
197 Ne5f6a08b424c4deeb62d4cd50ec10aae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Aged, 80 and over
199 rdf:type schema:DefinedTerm
200 Nee14a213bd8644a19c52160b67bf8834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Trastuzumab
202 rdf:type schema:DefinedTerm
203 Nfb4a350df30646d39609d67fd8119d1e rdf:first sg:person.0760064771.10
204 rdf:rest N226babb7de5b4927a6b46ee16eec9d80
205 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biological Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biochemistry and Cell Biology
210 rdf:type schema:DefinedTerm
211 sg:grant.2438823 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2012.132
212 rdf:type schema:MonetaryGrant
213 sg:grant.2478916 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2012.132
214 rdf:type schema:MonetaryGrant
215 sg:grant.2481110 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2012.132
216 rdf:type schema:MonetaryGrant
217 sg:journal.1017082 schema:issn 0007-0920
218 1532-1827
219 schema:name British Journal of Cancer
220 rdf:type schema:Periodical
221 sg:person.01017553075.00 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
222 schema:familyName Rutherford
223 schema:givenName T J
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017553075.00
225 rdf:type schema:Person
226 sg:person.01065666275.46 schema:affiliation https://www.grid.ac/institutes/grid.7637.5
227 schema:familyName Pecorelli
228 schema:givenName S
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065666275.46
230 rdf:type schema:Person
231 sg:person.01071066142.74 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
232 schema:familyName Ratner
233 schema:givenName E
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071066142.74
235 rdf:type schema:Person
236 sg:person.01134001475.57 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
237 schema:familyName Santin
238 schema:givenName A D
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134001475.57
240 rdf:type schema:Person
241 sg:person.01141233371.32 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
242 schema:familyName Abu-Khalaf
243 schema:givenName M
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141233371.32
245 rdf:type schema:Person
246 sg:person.01163412706.67 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
247 schema:familyName Azodi
248 schema:givenName M
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163412706.67
250 rdf:type schema:Person
251 sg:person.01207015645.37 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
252 schema:familyName Schwartz
253 schema:givenName P E
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207015645.37
255 rdf:type schema:Person
256 sg:person.01244366775.56 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
257 schema:familyName Bellone
258 schema:givenName S
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366775.56
260 rdf:type schema:Person
261 sg:person.01264655440.98 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
262 schema:familyName Buza
263 schema:givenName N
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264655440.98
265 rdf:type schema:Person
266 sg:person.01364015242.73 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
267 schema:familyName Cocco
268 schema:givenName E
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364015242.73
270 rdf:type schema:Person
271 sg:person.0714672065.28 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
272 schema:familyName Roque
273 schema:givenName D
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714672065.28
275 rdf:type schema:Person
276 sg:person.0734604232.35 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
277 schema:familyName Bortolomai
278 schema:givenName I
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734604232.35
280 rdf:type schema:Person
281 sg:person.0743746452.51 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
282 schema:familyName Silasi
283 schema:givenName D-A
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743746452.51
285 rdf:type schema:Person
286 sg:person.0760064771.10 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
287 schema:familyName Gasparrini
288 schema:givenName S
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760064771.10
290 rdf:type schema:Person
291 sg:pub.10.1007/s00253-007-0984-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1048798976
292 https://doi.org/10.1007/s00253-007-0984-y
293 rdf:type schema:CreativeWork
294 sg:pub.10.1007/s11095-006-9180-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053715955
295 https://doi.org/10.1007/s11095-006-9180-5
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/35052073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053565592
298 https://doi.org/10.1038/35052073
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/74704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000366392
301 https://doi.org/10.1038/74704
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/sj.bjc.6605448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011011108
304 https://doi.org/10.1038/sj.bjc.6605448
305 rdf:type schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1075051019 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1076034949 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1076911441 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1082695615 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1082776006 schema:CreativeWork
311 https://doi.org/10.1002/cncr.21308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027689264
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/0090-8258(83)90111-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012264639
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.ajog.2004.10.605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040419430
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.ijgo.2008.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039812231
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.it.2004.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051532365
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.molimm.2009.05.222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014997867
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.ygyno.2005.03.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030768836
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.ygyno.2005.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036554402
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.ygyno.2007.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034179467
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.ygyno.2011.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016178578
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0041-1345(02)03834-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038792395
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0167-5699(99)01537-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000751165
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1056/nejm199608293350907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010589799
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1056/nejm200103153441101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031768583
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1097/00000478-198203000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044024467
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1097/01.cco.0000239890.36408.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012774132
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1111/j.1525-1438.2006.00664.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010580997
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1158/0008-5472.can-05-3191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012893426
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1158/0008-5472.can-07-1811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025092386
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1182/blood.v100.9.3304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053408015
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1200/jco.2005.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019405939
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1200/jco.2005.03.4827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023211514
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1517/14712598.5.12.1593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067589586
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1586/era.11.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012117858
358 rdf:type schema:CreativeWork
359 https://doi.org/10.3322/caac.20121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032384183
360 rdf:type schema:CreativeWork
361 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
362 schema:name Department of Internal Medicine and Oncology, Yale University School of Medicine, New Haven, CT, USA
363 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
364 Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.7637.5 schema:alternateName University of Brescia
367 schema:name Division of Gynecologic Oncology, University of Brescia, Brescia, Italy
368 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...