Ontology type: schema:ScholarlyArticle Open Access: True
2011-03-08
AUTHORSA Palumbo, F Hauler, P Dziunycz, K Schwager, A Soltermann, F Pretto, C Alonso, G F Hofbauer, R W Boyle, D Neri
ABSTRACTBackground:The possibility of eradicating cancer by selective destruction of tumour blood vessels may represent an attractive therapeutic avenue, but most pharmaceutical agents investigated so far did not achieve complete cures and are not completely specific. Antibody conjugates now allow us to evaluate the impact of selective vascular shutdown on tumour viability and to study mechanisms of action.Methods:We synthesised a novel porphyrin-based photosensitiser suitable for conjugation to antibodies and assessed anticancer properties of its conjugate with L19, a clinical-stage human monoclonal antibody specific to the alternatively spliced EDB domain of fibronectin, a marker of tumour angiogenesis.Results:Here we show in two mouse model of cancer (F9 and A431) that L19 is capable of highly selective in vivo localisation around tumour blood vessels and that its conjugate with a photosensitiser allows selective disruption of tumour vasculature upon irradiation, leading to complete and long-lasting cancer eradication. Furthermore, depletion experiments revealed that natural killer cells are essential for the induction of long-lasting complete responses.Conclusions:These results reinforce the concept that vascular shutdown can induce a curative avalanche of tumour cell death. Immuno-photodynamic therapy may be particularly indicated for squamous cell carcinoma of the skin, which we show to be strongly positive for markers of angiogenesis. More... »
PAGES1106-1115
http://scigraph.springernature.com/pub.10.1038/bjc.2011.78
DOIhttp://dx.doi.org/10.1038/bjc.2011.78
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1020004152
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21386847
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Squamous Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorescent Antibody Technique",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunoconjugates",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Killer Cells, Natural",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred BALB C",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms, Experimental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neovascularization, Pathologic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Photochemotherapy",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Palumbo",
"givenName": "A",
"id": "sg:person.01120634634.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120634634.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Hauler",
"givenName": "F",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.412004.3",
"name": [
"Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Dziunycz",
"givenName": "P",
"id": "sg:person.0602123160.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602123160.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Philochem AG, c/o ETH Z\u00fcrich, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, HCI E520, 8093, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland",
"Philochem AG, c/o ETH Z\u00fcrich, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, HCI E520, 8093, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Schwager",
"givenName": "K",
"id": "sg:person.01073720454.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073720454.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.412004.3",
"name": [
"Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Soltermann",
"givenName": "A",
"id": "sg:person.0743264300.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743264300.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Pretto",
"givenName": "F",
"id": "sg:person.0624524014.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624524014.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Chemistry, University of Hull, Cottingham Road, Kingston-upon-Hull HU6 7RX, UK",
"id": "http://www.grid.ac/institutes/grid.9481.4",
"name": [
"Department of Chemistry, University of Hull, Cottingham Road, Kingston-upon-Hull HU6 7RX, UK"
],
"type": "Organization"
},
"familyName": "Alonso",
"givenName": "C",
"id": "sg:person.0663342455.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663342455.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.412004.3",
"name": [
"Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Hofbauer",
"givenName": "G F",
"id": "sg:person.010463412620.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010463412620.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Chemistry, University of Hull, Cottingham Road, Kingston-upon-Hull HU6 7RX, UK",
"id": "http://www.grid.ac/institutes/grid.9481.4",
"name": [
"Department of Chemistry, University of Hull, Cottingham Road, Kingston-upon-Hull HU6 7RX, UK"
],
"type": "Organization"
},
"familyName": "Boyle",
"givenName": "R W",
"id": "sg:person.01270352613.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270352613.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Z\u00fcrich, Wolfgang-Pauli-Strasse 10, 8093, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Neri",
"givenName": "D",
"id": "sg:person.0771467351.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771467351.71"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nrd1381",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006489607",
"https://doi.org/10.1038/nrd1381"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1039/b708320c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037361966",
"https://doi.org/10.1039/b708320c"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/6179",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035393625",
"https://doi.org/10.1038/6179"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0603-653",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010143012",
"https://doi.org/10.1038/nm0603-653"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt0302-264",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022798368",
"https://doi.org/10.1038/nbt0302-264"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603694",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035446044",
"https://doi.org/10.1038/sj.bjc.6603694"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrclinonc.2009.52",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030217783",
"https://doi.org/10.1038/nrclinonc.2009.52"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1627",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022080605",
"https://doi.org/10.1038/nrc1627"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603969",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042962854",
"https://doi.org/10.1038/sj.bjc.6603969"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1894",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051508795",
"https://doi.org/10.1038/nrc1894"
],
"type": "CreativeWork"
}
],
"datePublished": "2011-03-08",
"datePublishedReg": "2011-03-08",
"description": "Background:The possibility of eradicating cancer by selective destruction of tumour blood vessels may represent an attractive therapeutic avenue, but most pharmaceutical agents investigated so far did not achieve complete cures and are not completely specific. Antibody conjugates now allow us to evaluate the impact of selective vascular shutdown on tumour viability and to study mechanisms of action.Methods:We synthesised a novel porphyrin-based photosensitiser suitable for conjugation to antibodies and assessed anticancer properties of its conjugate with L19, a clinical-stage human monoclonal antibody specific to the alternatively spliced EDB domain of fibronectin, a marker of tumour angiogenesis.Results:Here we show in two mouse model of cancer (F9 and A431) that L19 is capable of highly selective in vivo localisation around tumour blood vessels and that its conjugate with a photosensitiser allows selective disruption of tumour vasculature upon irradiation, leading to complete and long-lasting cancer eradication. Furthermore, depletion experiments revealed that natural killer cells are essential for the induction of long-lasting complete responses.Conclusions:These results reinforce the concept that vascular shutdown can induce a curative avalanche of tumour cell death. Immuno-photodynamic therapy may be particularly indicated for squamous cell carcinoma of the skin, which we show to be strongly positive for markers of angiogenesis.",
"genre": "article",
"id": "sg:pub.10.1038/bjc.2011.78",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.5215906",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "104"
}
],
"keywords": [
"tumor blood vessels",
"blood vessels",
"vascular shutdown",
"natural killer cells",
"squamous cell carcinoma",
"attractive therapeutic avenue",
"markers of angiogenesis",
"human monoclonal antibody",
"mechanism of action",
"selective disruption",
"tumor cell death",
"complete response",
"killer cells",
"cell carcinoma",
"complete cure",
"mouse model",
"tumor viability",
"therapeutic avenues",
"tumor vasculature",
"tumor angiogenesis",
"cancer eradication",
"complete eradication",
"monoclonal antibodies",
"selective destruction",
"selective vascular shutdown",
"EDB domain",
"most pharmaceutical agents",
"pharmaceutical agents",
"antibodies",
"depletion experiments",
"anticancer properties",
"cancer",
"antibody conjugates",
"cell death",
"vivo localisation",
"angiogenesis",
"eradication",
"vessels",
"markers",
"conjugates",
"carcinoma",
"therapy",
"tumors",
"disruption",
"vasculature",
"death",
"cure",
"skin",
"photosensitiser",
"induction",
"fibronectin",
"cells",
"agents",
"response",
"L19",
"destruction",
"viability",
"action",
"localisation",
"mechanism",
"conjugation",
"impact",
"irradiation",
"avenues",
"results",
"possibility",
"model",
"domain",
"shutdown",
"experiments",
"concept",
"properties",
"avalanches"
],
"name": "A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels",
"pagination": "1106-1115",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1020004152"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/bjc.2011.78"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21386847"
]
}
],
"sameAs": [
"https://doi.org/10.1038/bjc.2011.78",
"https://app.dimensions.ai/details/publication/pub.1020004152"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:27",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_550.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/bjc.2011.78"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.78'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.78'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.78'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.78'
This table displays all metadata directly associated to this object as RDF triples.
297 TRIPLES
22 PREDICATES
121 URIs
102 LITERALS
18 BLANK NODES