Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

G Goebel, R Berger, A M Strasak, D Egle, E Müller-Holzner, S Schmidt, J Rainer, E Presul, W Parson, S Lang, A Jones, M Widschwendter, H Fiegl

ABSTRACT

BACKGROUND: The role of CHAC1 (cation transport regulator-like protein 1), a recently identified component of the unfolded protein response (UPR) pathway, in gynaecological cancers has not yet been characterised. Now, this work illustrates CHAC1 mRNA expression and associated clinical outcome in breast and ovarian cancer. METHODS: The prognostic value of CHAC1 and its two transcript variants was investigated in 116 breast and 133 ovarian tissues using quantitative real-time reverse-transcriptase PCR. Subsequently, we conducted functional studies using short-interfering RNA-mediated knockdown and plasmid-mediated overexpression of CHAC1 in breast and ovarian cancer cells. RESULTS: Poorly differentiated tumours exhibited higher CHAC1 mRNA expression (breast cancer: P=0.004; ovarian cancer: P=0.024). Hormone receptor-negative breast tumours and advanced-staged ovarian cancers demonstrated elevated CHAC1 mRNA expression levels (P<0.001 and P=0.026, respectively). The multivariate survival analysis showed a prognostic value of both transcript variants in breast cancer (transcript variant 1: RR(death) 6.7 (2.4-18.9); P<0.001), RR(relapse) 6.7 (2.1-21.3); P=0.001); (transcript variant 2: RR(death) 4.9 (2.0-12.4); P<0.001), RR(relapse) 8.0 (2.4-26.8); P<0.001). Ovarian cancer patients aged younger than 62.6 years with high CHAC1 mRNA expression showed poorer relapse-free- and overall-survival (P=0.030 and P=0.012, respectively). In functional studies CHAC1 knockdown suppressed cell migration, whereas ectopic overexpression opposed these effects. CONCLUSION: High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer. More... »

PAGES

189

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2011.510

DOI

http://dx.doi.org/10.1038/bjc.2011.510

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044016427

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22108517


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cation Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Splicing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goebel", 
        "givenName": "G", 
        "id": "sg:person.01347077464.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347077464.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Gynaecology and Obstetrics, Innsbruck Medical University, Anichstra\u00dfe 35, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "R", 
        "id": "sg:person.0622714211.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622714211.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strasak", 
        "givenName": "A M", 
        "id": "sg:person.0743772201.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743772201.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Gynaecology and Obstetrics, Innsbruck Medical University, Anichstra\u00dfe 35, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Egle", 
        "givenName": "D", 
        "id": "sg:person.01346230024.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346230024.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Gynaecology and Obstetrics, Innsbruck Medical University, Anichstra\u00dfe 35, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller-Holzner", 
        "givenName": "E", 
        "id": "sg:person.0762440433.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762440433.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Internal Medicine V, Innsbruck Medical University, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt", 
        "givenName": "S", 
        "id": "sg:person.01107145633.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107145633.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Biocenter Innsbruck, Division of Molecular Pathophysiology, Innsbruck Medical University, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rainer", 
        "givenName": "J", 
        "id": "sg:person.01076704640.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076704640.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Gynaecology and Obstetrics, Innsbruck Medical University, Anichstra\u00dfe 35, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Presul", 
        "givenName": "E", 
        "id": "sg:person.0714343040.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714343040.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Institute of Legal Medicine, Innsbruck Medical University, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parson", 
        "givenName": "W", 
        "id": "sg:person.0774575605.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774575605.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Innsbruck", 
          "id": "https://www.grid.ac/institutes/grid.5771.4", 
          "name": [
            "Department of Statistics, Faculty of Economics and Statistics, Leopold-Franzens University, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lang", 
        "givenName": "S", 
        "id": "sg:person.010223676761.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010223676761.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London W1T 7DN, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "A", 
        "id": "sg:person.01072443336.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072443336.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London W1T 7DN, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Widschwendter", 
        "givenName": "M", 
        "id": "sg:person.0737721764.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737721764.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Gynaecology and Obstetrics, Innsbruck Medical University, Anichstra\u00dfe 35, Innsbruck A-6020, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fiegl", 
        "givenName": "H", 
        "id": "sg:person.01216126365.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216126365.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bjc.6601392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004896249", 
          "https://doi.org/10.1038/sj.bjc.6601392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004896249", 
          "https://doi.org/10.1038/sj.bjc.6601392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:canc.0000031768.89246.d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007417422", 
          "https://doi.org/10.1023/b:canc.0000031768.89246.d7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/23.1.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007600751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008443664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008443664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0605457103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010354974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.04-3062fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010430452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016525230", 
          "https://doi.org/10.1038/nprot.2007.30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006332011207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017605970", 
          "https://doi.org/10.1023/a:1006332011207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020823593", 
          "https://doi.org/10.1038/sj.bjc.6605365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2010.01491.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022810743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023556722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023556722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026944005", 
          "https://doi.org/10.1038/nrc1505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026944005", 
          "https://doi.org/10.1038/nrc1505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annepidem.2008.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036992517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037484613", 
          "https://doi.org/10.1038/nsmb.2050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038755067", 
          "https://doi.org/10.1038/sj.onc.1208804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038755067", 
          "https://doi.org/10.1038/sj.onc.1208804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038755067", 
          "https://doi.org/10.1038/sj.onc.1208804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-006-0150-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040076091", 
          "https://doi.org/10.1007/s00109-006-0150-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-006-0150-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040076091", 
          "https://doi.org/10.1007/s00109-006-0150-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8278(03)00029-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050800988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8278(03)00029-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050800988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.10.826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051189282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074500494", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074957470", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.182.1.466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077828814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083143253", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01", 
    "datePublishedReg": "2012-01-01", 
    "description": "BACKGROUND: The role of CHAC1 (cation transport regulator-like protein 1), a recently identified component of the unfolded protein response (UPR) pathway, in gynaecological cancers has not yet been characterised. Now, this work illustrates CHAC1 mRNA expression and associated clinical outcome in breast and ovarian cancer.\nMETHODS: The prognostic value of CHAC1 and its two transcript variants was investigated in 116 breast and 133 ovarian tissues using quantitative real-time reverse-transcriptase PCR. Subsequently, we conducted functional studies using short-interfering RNA-mediated knockdown and plasmid-mediated overexpression of CHAC1 in breast and ovarian cancer cells.\nRESULTS: Poorly differentiated tumours exhibited higher CHAC1 mRNA expression (breast cancer: P=0.004; ovarian cancer: P=0.024). Hormone receptor-negative breast tumours and advanced-staged ovarian cancers demonstrated elevated CHAC1 mRNA expression levels (P<0.001 and P=0.026, respectively). The multivariate survival analysis showed a prognostic value of both transcript variants in breast cancer (transcript variant 1: RR(death) 6.7 (2.4-18.9); P<0.001), RR(relapse) 6.7 (2.1-21.3); P=0.001); (transcript variant 2: RR(death) 4.9 (2.0-12.4); P<0.001), RR(relapse) 8.0 (2.4-26.8); P<0.001). Ovarian cancer patients aged younger than 62.6 years with high CHAC1 mRNA expression showed poorer relapse-free- and overall-survival (P=0.030 and P=0.012, respectively). In functional studies CHAC1 knockdown suppressed cell migration, whereas ectopic overexpression opposed these effects.\nCONCLUSION: High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2011.510", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "106"
      }
    ], 
    "name": "Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients", 
    "pagination": "189", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d1aa3e6110d9de5c9451a78d7d6341396df67f31fcba57b0648926315cca5dd1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22108517"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2011.510"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044016427"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2011.510", 
      "https://app.dimensions.ai/details/publication/pub.1044016427"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2011510"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.510'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.510'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.510'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.510'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      67 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2011.510 schema:about N0fdfce5aa7eb4ca68d362c6aee32a3fd
2 N174e49941d3f402d95ec02ca91752afb
3 N186176afba214614b22b4f8c481bb2dd
4 N1d55c58a0e654b68a1f490cdc81a253b
5 N4fd16597379442b49afda291545e2869
6 N567828a48eb0425ebcbf7777c60e66f0
7 N6870782bf1814c0e87c4e8f20e959422
8 N6bab4d519e184786b7e24ff7f13b69de
9 N87f3575492654c06822cec7ba810cdfa
10 N92d1a9d17d2b4ee7ac515ac892790e79
11 Na5685297c1764215a2bda28f5ab2470b
12 Nb05366d46af0466491ba057c1d283019
13 Nd505975af34043739982a121aab5a38f
14 Nd6352eecafca4f65acac5352ca1e0eb7
15 Ne5c51b4391dd44c281d8597f9697100b
16 Nf21dfe0c42114a32b3313304a533ab55
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N84eaacd8513a49f0bc71170726fe772e
20 schema:citation sg:pub.10.1007/s00109-006-0150-5
21 sg:pub.10.1023/a:1006332011207
22 sg:pub.10.1023/b:canc.0000031768.89246.d7
23 sg:pub.10.1038/nprot.2007.30
24 sg:pub.10.1038/nrc1505
25 sg:pub.10.1038/nsmb.2050
26 sg:pub.10.1038/sj.bjc.6601392
27 sg:pub.10.1038/sj.bjc.6605365
28 sg:pub.10.1038/sj.onc.1208804
29 https://app.dimensions.ai/details/publication/pub.1074500494
30 https://app.dimensions.ai/details/publication/pub.1074957470
31 https://app.dimensions.ai/details/publication/pub.1083143253
32 https://doi.org/10.1002/ijc.25516
33 https://doi.org/10.1016/j.annepidem.2008.08.009
34 https://doi.org/10.1016/s0168-8278(03)00029-1
35 https://doi.org/10.1073/pnas.0605457103
36 https://doi.org/10.1093/carcin/23.1.123
37 https://doi.org/10.1093/jnci/92.10.826
38 https://doi.org/10.1093/jnci/dji237
39 https://doi.org/10.1096/fj.04-3062fje
40 https://doi.org/10.1111/j.1349-7006.2010.01491.x
41 https://doi.org/10.4049/jimmunol.182.1.466
42 schema:datePublished 2012-01
43 schema:datePublishedReg 2012-01-01
44 schema:description BACKGROUND: The role of CHAC1 (cation transport regulator-like protein 1), a recently identified component of the unfolded protein response (UPR) pathway, in gynaecological cancers has not yet been characterised. Now, this work illustrates CHAC1 mRNA expression and associated clinical outcome in breast and ovarian cancer. METHODS: The prognostic value of CHAC1 and its two transcript variants was investigated in 116 breast and 133 ovarian tissues using quantitative real-time reverse-transcriptase PCR. Subsequently, we conducted functional studies using short-interfering RNA-mediated knockdown and plasmid-mediated overexpression of CHAC1 in breast and ovarian cancer cells. RESULTS: Poorly differentiated tumours exhibited higher CHAC1 mRNA expression (breast cancer: P=0.004; ovarian cancer: P=0.024). Hormone receptor-negative breast tumours and advanced-staged ovarian cancers demonstrated elevated CHAC1 mRNA expression levels (P<0.001 and P=0.026, respectively). The multivariate survival analysis showed a prognostic value of both transcript variants in breast cancer (transcript variant 1: RR(death) 6.7 (2.4-18.9); P<0.001), RR(relapse) 6.7 (2.1-21.3); P=0.001); (transcript variant 2: RR(death) 4.9 (2.0-12.4); P<0.001), RR(relapse) 8.0 (2.4-26.8); P<0.001). Ovarian cancer patients aged younger than 62.6 years with high CHAC1 mRNA expression showed poorer relapse-free- and overall-survival (P=0.030 and P=0.012, respectively). In functional studies CHAC1 knockdown suppressed cell migration, whereas ectopic overexpression opposed these effects. CONCLUSION: High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N4c4ad243cbe84acf898ffacde628298d
49 Nc23d67e456f041648c34e3e067ef0039
50 sg:journal.1017082
51 schema:name Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients
52 schema:pagination 189
53 schema:productId N2196ab960cef42a8ade12139fad4dfa8
54 N6060875141cb48de8180c3f5291bfcc6
55 N6289c89b6ca4468ba304b072a6c3dd02
56 Ncd00da3c34e14a369fb1b515b7e87800
57 Ne65e47072b1f4a50a235ffe120dbc460
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044016427
59 https://doi.org/10.1038/bjc.2011.510
60 schema:sdDatePublished 2019-04-10T13:25
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N3d237e71a88944be916fc7e3e56a8efa
63 schema:url https://www.nature.com/articles/bjc2011510
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N01ca8d92941745e4911433e7b850d49c rdf:first sg:person.0774575605.59
68 rdf:rest N0b02d0fdad7e4c3ea47da1202c570615
69 N0b02d0fdad7e4c3ea47da1202c570615 rdf:first sg:person.010223676761.81
70 rdf:rest Nd01e810287ba43149ce28c933ef7afaf
71 N0fdfce5aa7eb4ca68d362c6aee32a3fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Aged, 80 and over
73 rdf:type schema:DefinedTerm
74 N174e49941d3f402d95ec02ca91752afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Humans
76 rdf:type schema:DefinedTerm
77 N186176afba214614b22b4f8c481bb2dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Female
79 rdf:type schema:DefinedTerm
80 N1d55c58a0e654b68a1f490cdc81a253b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Gene Knockdown Techniques
82 rdf:type schema:DefinedTerm
83 N2196ab960cef42a8ade12139fad4dfa8 schema:name dimensions_id
84 schema:value pub.1044016427
85 rdf:type schema:PropertyValue
86 N3d237e71a88944be916fc7e3e56a8efa schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N3dbdeca363704ae8b3bf353d0c558821 rdf:first sg:person.0743772201.77
89 rdf:rest N5317a4d8b1934ecf871abe19662c7103
90 N473df1231d4a4ceeb50d0ab975adcc1f rdf:first sg:person.0622714211.75
91 rdf:rest N3dbdeca363704ae8b3bf353d0c558821
92 N4c4ad243cbe84acf898ffacde628298d schema:volumeNumber 106
93 rdf:type schema:PublicationVolume
94 N4fd16597379442b49afda291545e2869 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Ovarian Neoplasms
96 rdf:type schema:DefinedTerm
97 N5317a4d8b1934ecf871abe19662c7103 rdf:first sg:person.01346230024.80
98 rdf:rest N7556a4e9919144bd96ede507c2efc5b8
99 N567828a48eb0425ebcbf7777c60e66f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Base Sequence
101 rdf:type schema:DefinedTerm
102 N6060875141cb48de8180c3f5291bfcc6 schema:name readcube_id
103 schema:value d1aa3e6110d9de5c9451a78d7d6341396df67f31fcba57b0648926315cca5dd1
104 rdf:type schema:PropertyValue
105 N6289c89b6ca4468ba304b072a6c3dd02 schema:name pubmed_id
106 schema:value 22108517
107 rdf:type schema:PropertyValue
108 N6870782bf1814c0e87c4e8f20e959422 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Breast Neoplasms
110 rdf:type schema:DefinedTerm
111 N6bab4d519e184786b7e24ff7f13b69de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Adult
113 rdf:type schema:DefinedTerm
114 N7556a4e9919144bd96ede507c2efc5b8 rdf:first sg:person.0762440433.53
115 rdf:rest Nf9ef80c9817b47d59d396d8553414807
116 N84eaacd8513a49f0bc71170726fe772e rdf:first sg:person.01347077464.05
117 rdf:rest N473df1231d4a4ceeb50d0ab975adcc1f
118 N87f3575492654c06822cec7ba810cdfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name RNA Splicing
120 rdf:type schema:DefinedTerm
121 N92d1a9d17d2b4ee7ac515ac892790e79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cation Transport Proteins
123 rdf:type schema:DefinedTerm
124 Na5685297c1764215a2bda28f5ab2470b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Aged
126 rdf:type schema:DefinedTerm
127 Nb05366d46af0466491ba057c1d283019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name RNA, Messenger
129 rdf:type schema:DefinedTerm
130 Nc23d67e456f041648c34e3e067ef0039 schema:issueNumber 1
131 rdf:type schema:PublicationIssue
132 Ncd00da3c34e14a369fb1b515b7e87800 schema:name doi
133 schema:value 10.1038/bjc.2011.510
134 rdf:type schema:PropertyValue
135 Nd01e810287ba43149ce28c933ef7afaf rdf:first sg:person.01072443336.33
136 rdf:rest Nd84f169bbf7c4ac9bb530ee7a14862f5
137 Nd0d0c338f8b546ed990feeb3edfa989d rdf:first sg:person.01076704640.99
138 rdf:rest Nefd126decb28411f86da6e03198bd161
139 Nd505975af34043739982a121aab5a38f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name DNA Primers
141 rdf:type schema:DefinedTerm
142 Nd6352eecafca4f65acac5352ca1e0eb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Blotting, Western
144 rdf:type schema:DefinedTerm
145 Nd84f169bbf7c4ac9bb530ee7a14862f5 rdf:first sg:person.0737721764.81
146 rdf:rest Ne02c383b69f342539fa1fb0f22e161f7
147 Ne02c383b69f342539fa1fb0f22e161f7 rdf:first sg:person.01216126365.32
148 rdf:rest rdf:nil
149 Ne5c51b4391dd44c281d8597f9697100b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cell Line, Tumor
151 rdf:type schema:DefinedTerm
152 Ne65e47072b1f4a50a235ffe120dbc460 schema:name nlm_unique_id
153 schema:value 0370635
154 rdf:type schema:PropertyValue
155 Nefd126decb28411f86da6e03198bd161 rdf:first sg:person.0714343040.53
156 rdf:rest N01ca8d92941745e4911433e7b850d49c
157 Nf21dfe0c42114a32b3313304a533ab55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Middle Aged
159 rdf:type schema:DefinedTerm
160 Nf9ef80c9817b47d59d396d8553414807 rdf:first sg:person.01107145633.26
161 rdf:rest Nd0d0c338f8b546ed990feeb3edfa989d
162 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
163 schema:name Medical and Health Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
166 schema:name Oncology and Carcinogenesis
167 rdf:type schema:DefinedTerm
168 sg:journal.1017082 schema:issn 0007-0920
169 1532-1827
170 schema:name British Journal of Cancer
171 rdf:type schema:Periodical
172 sg:person.010223676761.81 schema:affiliation https://www.grid.ac/institutes/grid.5771.4
173 schema:familyName Lang
174 schema:givenName S
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010223676761.81
176 rdf:type schema:Person
177 sg:person.01072443336.33 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
178 schema:familyName Jones
179 schema:givenName A
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072443336.33
181 rdf:type schema:Person
182 sg:person.01076704640.99 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
183 schema:familyName Rainer
184 schema:givenName J
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076704640.99
186 rdf:type schema:Person
187 sg:person.01107145633.26 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
188 schema:familyName Schmidt
189 schema:givenName S
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107145633.26
191 rdf:type schema:Person
192 sg:person.01216126365.32 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
193 schema:familyName Fiegl
194 schema:givenName H
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216126365.32
196 rdf:type schema:Person
197 sg:person.01346230024.80 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
198 schema:familyName Egle
199 schema:givenName D
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346230024.80
201 rdf:type schema:Person
202 sg:person.01347077464.05 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
203 schema:familyName Goebel
204 schema:givenName G
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347077464.05
206 rdf:type schema:Person
207 sg:person.0622714211.75 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
208 schema:familyName Berger
209 schema:givenName R
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622714211.75
211 rdf:type schema:Person
212 sg:person.0714343040.53 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
213 schema:familyName Presul
214 schema:givenName E
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714343040.53
216 rdf:type schema:Person
217 sg:person.0737721764.81 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
218 schema:familyName Widschwendter
219 schema:givenName M
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737721764.81
221 rdf:type schema:Person
222 sg:person.0743772201.77 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
223 schema:familyName Strasak
224 schema:givenName A M
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743772201.77
226 rdf:type schema:Person
227 sg:person.0762440433.53 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
228 schema:familyName Müller-Holzner
229 schema:givenName E
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762440433.53
231 rdf:type schema:Person
232 sg:person.0774575605.59 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
233 schema:familyName Parson
234 schema:givenName W
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774575605.59
236 rdf:type schema:Person
237 sg:pub.10.1007/s00109-006-0150-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040076091
238 https://doi.org/10.1007/s00109-006-0150-5
239 rdf:type schema:CreativeWork
240 sg:pub.10.1023/a:1006332011207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017605970
241 https://doi.org/10.1023/a:1006332011207
242 rdf:type schema:CreativeWork
243 sg:pub.10.1023/b:canc.0000031768.89246.d7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007417422
244 https://doi.org/10.1023/b:canc.0000031768.89246.d7
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nprot.2007.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016525230
247 https://doi.org/10.1038/nprot.2007.30
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nrc1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026944005
250 https://doi.org/10.1038/nrc1505
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nsmb.2050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037484613
253 https://doi.org/10.1038/nsmb.2050
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/sj.bjc.6601392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004896249
256 https://doi.org/10.1038/sj.bjc.6601392
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/sj.bjc.6605365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020823593
259 https://doi.org/10.1038/sj.bjc.6605365
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/sj.onc.1208804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038755067
262 https://doi.org/10.1038/sj.onc.1208804
263 rdf:type schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1074500494 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1074957470 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083143253 schema:CreativeWork
267 https://doi.org/10.1002/ijc.25516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008443664
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.annepidem.2008.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036992517
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0168-8278(03)00029-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050800988
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1073/pnas.0605457103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010354974
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1093/carcin/23.1.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007600751
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1093/jnci/92.10.826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051189282
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1093/jnci/dji237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023556722
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1096/fj.04-3062fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1010430452
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.1349-7006.2010.01491.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022810743
284 rdf:type schema:CreativeWork
285 https://doi.org/10.4049/jimmunol.182.1.466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077828814
286 rdf:type schema:CreativeWork
287 https://www.grid.ac/institutes/grid.5361.1 schema:alternateName Innsbruck Medical University
288 schema:name Biocenter Innsbruck, Division of Molecular Pathophysiology, Innsbruck Medical University, Innsbruck A-6020, Austria
289 Department of Gynaecology and Obstetrics, Innsbruck Medical University, Anichstraße 35, Innsbruck A-6020, Austria
290 Department of Internal Medicine V, Innsbruck Medical University, Innsbruck A-6020, Austria
291 Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck A-6020, Austria
292 Institute of Legal Medicine, Innsbruck Medical University, Innsbruck A-6020, Austria
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.5771.4 schema:alternateName University of Innsbruck
295 schema:name Department of Statistics, Faculty of Economics and Statistics, Leopold-Franzens University, Innsbruck A-6020, Austria
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
298 schema:name Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London W1T 7DN, UK
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...