High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11-17

AUTHORS

Z Janjetovic, A A Brozyna, R C Tuckey, T-K Kim, M N Nguyen, W Jozwicki, S R Pfeffer, L M Pfeffer, A T Slominski

ABSTRACT

Background:Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action.Methods:Cultured melanoma cells were used for mechanistic studies on NF-κB activity, utilising immunofluorescence, western blotting, EMSA, ELISA, gene reporter, and estimated DNA synthesis assays. Formalin-fixed, paraffin-embedded specimens from melanoma patients were used for immunocytochemical analysis of NF-κB activity in situ.Results:Novel 20-hydroxyvitamin (20(OH)D3) and classical 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) secosteroids inhibited melanoma cell proliferation. Active forms of vitamin D were found to inhibit NF-κB activity in nonpigmented cells, while having no effect on pigmented cells. Treatment of nonpigmented cells with vitamin D3 derivatives inhibited NF-κB DNA binding and NF-κB-dependent reporter assays, as well as inhibited the nuclear translocation of the p65 NF-κB subunit and its accumulation in the cytoplasm. Moreover, analysis of biopsies of melanoma patients showed that nonpigmented and slightly pigmented melanomas displayed higher nuclear NF-κB p65 expression than highly pigmented melanomas.Conclusion:Classical 1,25(OH)2D3 and novel 20(OH)D3 hydroxyderivatives of vitamin D3 can target NF-κB and regulate melanoma progression in nonpigmented melanoma cells. Melanin pigmentation is associated with the resistance of melanomas to 20(OH)D3 and 1,25(OH)2D3 treatment. More... »

PAGES

1874-1884

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2011.458

DOI

http://dx.doi.org/10.1038/bjc.2011.458

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025567432

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22095230


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholecalciferol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janjetovic", 
        "givenName": "Z", 
        "id": "sg:person.0576400136.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576400136.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Pathology and Pathomorphology, Oncology Centre \u2013 Prof. Franciszek \u0141ukaszczyk Memorial Hospital, Collegium Medicum, Nicolaus Copernicus University, 85-067, Bydgoszcz, Poland", 
          "id": "http://www.grid.ac/institutes/grid.5374.5", 
          "name": [
            "Department of Tumor Pathology and Pathomorphology, Oncology Centre \u2013 Prof. Franciszek \u0141ukaszczyk Memorial Hospital, Collegium Medicum, Nicolaus Copernicus University, 85-067, Bydgoszcz, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brozyna", 
        "givenName": "A A", 
        "id": "sg:person.01247433576.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247433576.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1012.2", 
          "name": [
            "School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuckey", 
        "givenName": "R C", 
        "id": "sg:person.01205643625.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205643625.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "T-K", 
        "id": "sg:person.01122406003.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122406003.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1012.2", 
          "name": [
            "School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nguyen", 
        "givenName": "M N", 
        "id": "sg:person.01031642617.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031642617.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Pathology and Pathomorphology, Oncology Centre \u2013 Prof. Franciszek \u0141ukaszczyk Memorial Hospital, Collegium Medicum, Nicolaus Copernicus University, 85-067, Bydgoszcz, Poland", 
          "id": "http://www.grid.ac/institutes/grid.5374.5", 
          "name": [
            "Department of Tumor Pathology and Pathomorphology, Oncology Centre \u2013 Prof. Franciszek \u0141ukaszczyk Memorial Hospital, Collegium Medicum, Nicolaus Copernicus University, 85-067, Bydgoszcz, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jozwicki", 
        "givenName": "W", 
        "id": "sg:person.01173540763.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173540763.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfeffer", 
        "givenName": "S R", 
        "id": "sg:person.0704506503.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704506503.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfeffer", 
        "givenName": "L M", 
        "id": "sg:person.01054607747.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054607747.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slominski", 
        "givenName": "A T", 
        "id": "sg:person.016612034677.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612034677.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00403-004-0509-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043874323", 
          "https://doi.org/10.1007/s00403-004-0509-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-005-1264-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029598834", 
          "https://doi.org/10.1007/s00428-005-1264-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021224284", 
          "https://doi.org/10.1038/nrc2196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024581782", 
          "https://doi.org/10.1038/nrc780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-37696-5_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042425624", 
          "https://doi.org/10.1007/978-3-540-37696-5_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-55580-0_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022954906", 
          "https://doi.org/10.1007/978-3-642-55580-0_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11626-999-0093-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002462565", 
          "https://doi.org/10.1007/s11626-999-0093-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006201059", 
          "https://doi.org/10.1038/nature05660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051330539", 
          "https://doi.org/10.1038/sj.onc.1206454"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-11-17", 
    "datePublishedReg": "2011-11-17", 
    "description": "Background:Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-\u03baB (NF-\u03baB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action.Methods:Cultured melanoma cells were used for mechanistic studies on NF-\u03baB activity, utilising immunofluorescence, western blotting, EMSA, ELISA, gene reporter, and estimated DNA synthesis assays. Formalin-fixed, paraffin-embedded specimens from melanoma patients were used for immunocytochemical analysis of NF-\u03baB activity in situ.Results:Novel 20-hydroxyvitamin (20(OH)D3) and classical 1\u03b1,25-dihydroxyvitamin D3 (1,25(OH)2D3) secosteroids inhibited melanoma cell proliferation. Active forms of vitamin D were found to inhibit NF-\u03baB activity in nonpigmented cells, while having no effect on pigmented cells. Treatment of nonpigmented cells with vitamin D3 derivatives inhibited NF-\u03baB DNA binding and NF-\u03baB-dependent reporter assays, as well as inhibited the nuclear translocation of the p65 NF-\u03baB subunit and its accumulation in the cytoplasm. Moreover, analysis of biopsies of melanoma patients showed that nonpigmented and slightly pigmented melanomas displayed higher nuclear NF-\u03baB p65 expression than highly pigmented melanomas.Conclusion:Classical 1,25(OH)2D3 and novel 20(OH)D3 hydroxyderivatives of vitamin D3 can target NF-\u03baB and regulate melanoma progression in nonpigmented melanoma cells. Melanin pigmentation is associated with the resistance of melanomas to 20(OH)D3 and 1,25(OH)2D3 treatment.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/bjc.2011.458", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2464643", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479861", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2465059", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "105"
      }
    ], 
    "keywords": [
      "NF-\u03baB activity", 
      "vitamin D3 derivatives", 
      "melanoma patients", 
      "melanoma cells", 
      "nuclear NF-\u03baB p65 expression", 
      "D3 derivatives", 
      "NF-\u03baB p65 expression", 
      "p65 NF-\u03baB subunit", 
      "high basal NF-\u03baB activity", 
      "resistance of melanoma", 
      "analysis of biopsies", 
      "basal NF-\u03baB activity", 
      "NF-\u03baB subunits", 
      "cultured melanoma cells", 
      "NF-\u03baB DNA binding", 
      "melanoma cell proliferation", 
      "NF-\u03baB-dependent reporter", 
      "vitamin D", 
      "p65 expression", 
      "vitamin D3", 
      "NF-\u03baB", 
      "current modalities", 
      "therapeutic resistance", 
      "melanoma", 
      "melanoma progression", 
      "Western blotting", 
      "molecular targets", 
      "nuclear translocation", 
      "immunocytochemical analysis", 
      "cell proliferation", 
      "cancer therapy", 
      "patients", 
      "extent of pigmentation", 
      "therapy", 
      "pigmented cells", 
      "gene reporter", 
      "melanin pigmentation", 
      "DNA binding", 
      "cells", 
      "treatment", 
      "DNA synthesis", 
      "active form", 
      "biopsy", 
      "activity", 
      "ELISA", 
      "progression", 
      "reporter", 
      "important role", 
      "formalin", 
      "immunofluorescence", 
      "pigmentation", 
      "D3", 
      "blotting", 
      "modalities", 
      "mechanistic studies", 
      "enhanced sensitivity", 
      "proliferation", 
      "secosteroids", 
      "paraffin", 
      "resistance", 
      "expression", 
      "EMSA", 
      "hydroxyderivatives", 
      "subunits", 
      "cytoplasm", 
      "translocation", 
      "target", 
      "study", 
      "binding", 
      "role", 
      "action", 
      "specimens", 
      "accumulation", 
      "sensitivity", 
      "effect", 
      "analysis", 
      "extent", 
      "derivatives", 
      "situ", 
      "synthesis", 
      "form", 
      "novel", 
      "Classical"
    ], 
    "name": "High basal NF-\u03baB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives", 
    "pagination": "1874-1884", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025567432"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2011.458"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22095230"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2011.458", 
      "https://app.dimensions.ai/details/publication/pub.1025567432"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_545.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/bjc.2011.458"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.458'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.458'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.458'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.458'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      21 PREDICATES      123 URIs      106 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2011.458 schema:about N29ed9810698447c38213e7457d3bccc5
2 N3692a7cdf1fc4603992e6f773e814d51
3 N69c99c77295d4d01a39716d9bdef6bf6
4 N881ce019fc004726855922fe96fb1223
5 N8b599618537c4534a74a80579e24f819
6 Nc86e59cfb6564dd9a753aab51a5b5bed
7 anzsrc-for:11
8 anzsrc-for:1112
9 schema:author Naa5058f19d744ff884623265e77f1cf6
10 schema:citation sg:pub.10.1007/978-3-540-37696-5_16
11 sg:pub.10.1007/978-3-642-55580-0_1
12 sg:pub.10.1007/s00403-004-0509-9
13 sg:pub.10.1007/s00428-005-1264-9
14 sg:pub.10.1007/s11626-999-0093-6
15 sg:pub.10.1038/nature05660
16 sg:pub.10.1038/nrc2196
17 sg:pub.10.1038/nrc780
18 sg:pub.10.1038/sj.onc.1206454
19 schema:datePublished 2011-11-17
20 schema:datePublishedReg 2011-11-17
21 schema:description Background:Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action.Methods:Cultured melanoma cells were used for mechanistic studies on NF-κB activity, utilising immunofluorescence, western blotting, EMSA, ELISA, gene reporter, and estimated DNA synthesis assays. Formalin-fixed, paraffin-embedded specimens from melanoma patients were used for immunocytochemical analysis of NF-κB activity in situ.Results:Novel 20-hydroxyvitamin (20(OH)D3) and classical 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) secosteroids inhibited melanoma cell proliferation. Active forms of vitamin D were found to inhibit NF-κB activity in nonpigmented cells, while having no effect on pigmented cells. Treatment of nonpigmented cells with vitamin D3 derivatives inhibited NF-κB DNA binding and NF-κB-dependent reporter assays, as well as inhibited the nuclear translocation of the p65 NF-κB subunit and its accumulation in the cytoplasm. Moreover, analysis of biopsies of melanoma patients showed that nonpigmented and slightly pigmented melanomas displayed higher nuclear NF-κB p65 expression than highly pigmented melanomas.Conclusion:Classical 1,25(OH)2D3 and novel 20(OH)D3 hydroxyderivatives of vitamin D3 can target NF-κB and regulate melanoma progression in nonpigmented melanoma cells. Melanin pigmentation is associated with the resistance of melanomas to 20(OH)D3 and 1,25(OH)2D3 treatment.
22 schema:genre article
23 schema:isAccessibleForFree true
24 schema:isPartOf N065c5d51cfb247b39f8b1354c3ada321
25 N8384663efedf489c80e6842be967245d
26 sg:journal.1017082
27 schema:keywords Classical
28 D3
29 D3 derivatives
30 DNA binding
31 DNA synthesis
32 ELISA
33 EMSA
34 NF-κB
35 NF-κB DNA binding
36 NF-κB activity
37 NF-κB p65 expression
38 NF-κB subunits
39 NF-κB-dependent reporter
40 Western blotting
41 accumulation
42 action
43 active form
44 activity
45 analysis
46 analysis of biopsies
47 basal NF-κB activity
48 binding
49 biopsy
50 blotting
51 cancer therapy
52 cell proliferation
53 cells
54 cultured melanoma cells
55 current modalities
56 cytoplasm
57 derivatives
58 effect
59 enhanced sensitivity
60 expression
61 extent
62 extent of pigmentation
63 form
64 formalin
65 gene reporter
66 high basal NF-κB activity
67 hydroxyderivatives
68 immunocytochemical analysis
69 immunofluorescence
70 important role
71 mechanistic studies
72 melanin pigmentation
73 melanoma
74 melanoma cell proliferation
75 melanoma cells
76 melanoma patients
77 melanoma progression
78 modalities
79 molecular targets
80 novel
81 nuclear NF-κB p65 expression
82 nuclear translocation
83 p65 NF-κB subunit
84 p65 expression
85 paraffin
86 patients
87 pigmentation
88 pigmented cells
89 progression
90 proliferation
91 reporter
92 resistance
93 resistance of melanoma
94 role
95 secosteroids
96 sensitivity
97 situ
98 specimens
99 study
100 subunits
101 synthesis
102 target
103 therapeutic resistance
104 therapy
105 translocation
106 treatment
107 vitamin D
108 vitamin D3
109 vitamin D3 derivatives
110 schema:name High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives
111 schema:pagination 1874-1884
112 schema:productId N1b0398af2dd14c978c6e3d0a062f2a98
113 N2aab0d0d4c514570a5a2d5315b2eb6b5
114 Nc875b65edc8348029e16b1d1097b084a
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025567432
116 https://doi.org/10.1038/bjc.2011.458
117 schema:sdDatePublished 2022-10-01T06:37
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher N8bb4ca7ebf4d4287bd4f47fbde5be66d
120 schema:url https://doi.org/10.1038/bjc.2011.458
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N0179753f56724d5cbbb676064eb5bdf5 rdf:first sg:person.01031642617.87
125 rdf:rest N458b3a9f55d4454b82698f7aa9c3a6f3
126 N065c5d51cfb247b39f8b1354c3ada321 schema:volumeNumber 105
127 rdf:type schema:PublicationVolume
128 N1b0398af2dd14c978c6e3d0a062f2a98 schema:name doi
129 schema:value 10.1038/bjc.2011.458
130 rdf:type schema:PropertyValue
131 N29ed9810698447c38213e7457d3bccc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Melanoma
133 rdf:type schema:DefinedTerm
134 N2aab0d0d4c514570a5a2d5315b2eb6b5 schema:name dimensions_id
135 schema:value pub.1025567432
136 rdf:type schema:PropertyValue
137 N3692a7cdf1fc4603992e6f773e814d51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Line, Tumor
139 rdf:type schema:DefinedTerm
140 N458b3a9f55d4454b82698f7aa9c3a6f3 rdf:first sg:person.01173540763.45
141 rdf:rest Nce3bf179d0e94d48a85d87cc9a0e2366
142 N61c81939925548fbbfdddab919119330 rdf:first sg:person.01054607747.10
143 rdf:rest Nd2395a2884234a50b4b29dfac03bceb2
144 N69c99c77295d4d01a39716d9bdef6bf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Cholecalciferol
146 rdf:type schema:DefinedTerm
147 N8384663efedf489c80e6842be967245d schema:issueNumber 12
148 rdf:type schema:PublicationIssue
149 N881ce019fc004726855922fe96fb1223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name NF-kappa B
151 rdf:type schema:DefinedTerm
152 N8b599618537c4534a74a80579e24f819 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Humans
154 rdf:type schema:DefinedTerm
155 N8bb4ca7ebf4d4287bd4f47fbde5be66d schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 Naa5058f19d744ff884623265e77f1cf6 rdf:first sg:person.0576400136.15
158 rdf:rest Nf35b1039461446cb92f4dbad4ea94178
159 Nc0aadf3cee7342019eb4c98f9a78f778 rdf:first sg:person.01122406003.26
160 rdf:rest N0179753f56724d5cbbb676064eb5bdf5
161 Nc86e59cfb6564dd9a753aab51a5b5bed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cell Division
163 rdf:type schema:DefinedTerm
164 Nc875b65edc8348029e16b1d1097b084a schema:name pubmed_id
165 schema:value 22095230
166 rdf:type schema:PropertyValue
167 Nce3bf179d0e94d48a85d87cc9a0e2366 rdf:first sg:person.0704506503.61
168 rdf:rest N61c81939925548fbbfdddab919119330
169 Nd2395a2884234a50b4b29dfac03bceb2 rdf:first sg:person.016612034677.24
170 rdf:rest rdf:nil
171 Ndf92cdc87c3d45bb85bb72166a3dfb6b rdf:first sg:person.01205643625.44
172 rdf:rest Nc0aadf3cee7342019eb4c98f9a78f778
173 Nf35b1039461446cb92f4dbad4ea94178 rdf:first sg:person.01247433576.16
174 rdf:rest Ndf92cdc87c3d45bb85bb72166a3dfb6b
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
179 schema:name Oncology and Carcinogenesis
180 rdf:type schema:DefinedTerm
181 sg:grant.2464643 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2011.458
182 rdf:type schema:MonetaryGrant
183 sg:grant.2465059 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2011.458
184 rdf:type schema:MonetaryGrant
185 sg:grant.2479861 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2011.458
186 rdf:type schema:MonetaryGrant
187 sg:journal.1017082 schema:issn 0007-0920
188 1532-1827
189 schema:name British Journal of Cancer
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.01031642617.87 schema:affiliation grid-institutes:grid.1012.2
193 schema:familyName Nguyen
194 schema:givenName M N
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031642617.87
196 rdf:type schema:Person
197 sg:person.01054607747.10 schema:affiliation grid-institutes:grid.267301.1
198 schema:familyName Pfeffer
199 schema:givenName L M
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054607747.10
201 rdf:type schema:Person
202 sg:person.01122406003.26 schema:affiliation grid-institutes:grid.267301.1
203 schema:familyName Kim
204 schema:givenName T-K
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122406003.26
206 rdf:type schema:Person
207 sg:person.01173540763.45 schema:affiliation grid-institutes:grid.5374.5
208 schema:familyName Jozwicki
209 schema:givenName W
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173540763.45
211 rdf:type schema:Person
212 sg:person.01205643625.44 schema:affiliation grid-institutes:grid.1012.2
213 schema:familyName Tuckey
214 schema:givenName R C
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205643625.44
216 rdf:type schema:Person
217 sg:person.01247433576.16 schema:affiliation grid-institutes:grid.5374.5
218 schema:familyName Brozyna
219 schema:givenName A A
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247433576.16
221 rdf:type schema:Person
222 sg:person.016612034677.24 schema:affiliation grid-institutes:grid.267301.1
223 schema:familyName Slominski
224 schema:givenName A T
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612034677.24
226 rdf:type schema:Person
227 sg:person.0576400136.15 schema:affiliation grid-institutes:grid.267301.1
228 schema:familyName Janjetovic
229 schema:givenName Z
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576400136.15
231 rdf:type schema:Person
232 sg:person.0704506503.61 schema:affiliation grid-institutes:grid.267301.1
233 schema:familyName Pfeffer
234 schema:givenName S R
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704506503.61
236 rdf:type schema:Person
237 sg:pub.10.1007/978-3-540-37696-5_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042425624
238 https://doi.org/10.1007/978-3-540-37696-5_16
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/978-3-642-55580-0_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022954906
241 https://doi.org/10.1007/978-3-642-55580-0_1
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s00403-004-0509-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043874323
244 https://doi.org/10.1007/s00403-004-0509-9
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s00428-005-1264-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029598834
247 https://doi.org/10.1007/s00428-005-1264-9
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s11626-999-0093-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002462565
250 https://doi.org/10.1007/s11626-999-0093-6
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nature05660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006201059
253 https://doi.org/10.1038/nature05660
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nrc2196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021224284
256 https://doi.org/10.1038/nrc2196
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nrc780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024581782
259 https://doi.org/10.1038/nrc780
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/sj.onc.1206454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051330539
262 https://doi.org/10.1038/sj.onc.1206454
263 rdf:type schema:CreativeWork
264 grid-institutes:grid.1012.2 schema:alternateName School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia
265 schema:name School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia
266 rdf:type schema:Organization
267 grid-institutes:grid.267301.1 schema:alternateName Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA
268 schema:name Department of Pathology and Laboratory Medicine, Department of Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, 38163, Memphis, TN, USA
269 rdf:type schema:Organization
270 grid-institutes:grid.5374.5 schema:alternateName Department of Tumor Pathology and Pathomorphology, Oncology Centre – Prof. Franciszek Łukaszczyk Memorial Hospital, Collegium Medicum, Nicolaus Copernicus University, 85-067, Bydgoszcz, Poland
271 schema:name Department of Tumor Pathology and Pathomorphology, Oncology Centre – Prof. Franciszek Łukaszczyk Memorial Hospital, Collegium Medicum, Nicolaus Copernicus University, 85-067, Bydgoszcz, Poland
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...