Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11

AUTHORS

E Giovannetti, P A Zucali, Y G Assaraf, L G Leon, K Smid, C Alecci, F Giancola, A Destro, L Gianoncelli, E Lorenzi, M Roncalli, A Santoro, G J Peters

ABSTRACT

BACKGROUND: Although pemetrexed, a potent thymidylate synthase (TS) inhibitor, enhances the cytoytoxic effect of platinum compounds against malignant pleural mesothelioma (MPM), novel combinations with effective targeted therapies are warranted. To this end, the current study evaluates new targeted agents and their pharmacological interaction with carboplatin-pemetrexed in human MPM cell lines. METHODS: We treated H2052, H2452, H28 and MSTO-211H cells with carboplatin, pemetrexed and targeted compounds (gefitinib, erlotinib, sorafenib, vandetanib, enzastaurin and ZM447439) and evaluated the modulation of pivotal pathways in drug activity and cancer cell proliferation. RESULTS: Vandetanib emerged as the compound with the most potent cytotoxic activity, which interacted synergistically with carboplatin and pemetrexed. Drug combinations blocked Akt phosphorylation and increased apoptosis. Vandetanib significantly downregulated epidermal growth factor receptor (EGFR)/Erk/Akt phosphorylation as well as E2F-1 mRNA and TS mRNA/protein levels. Moreover, pemetrexed decreased Akt phosphorylation and expression of DNA repair genes. Finally, most MPM samples displayed detectable levels of EGFR and TS, the variability of which could be used for patients' stratification in future trials with vandetanib-pemetrexed-carboplatin combination. CONCLUSION: Vandetanib markedly enhances pemetrexed-carboplatin activity against human MPM cells. Induction of apoptosis, modulation of EGFR/Akt/Erk phosphorylation and expression of key determinants for pemetrexed and carboplatin activity contribute to this synergistic interaction, and, together with the expression of these determinants in MPM samples, warrant further clinical investigation. More... »

PAGES

1542

References to SciGraph publications

  • 2010-12. Synergistic effect of gefitinib and rofecoxib in mesothelioma cells in MOLECULAR CANCER
  • 2010-02. The role of folate receptor alpha (FRα) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy in BRITISH JOURNAL OF CANCER
  • 2009-05. Next generation oncology drug development: opportunities and challenges in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2010-08. Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2008-09. Molecular pathways involved in the synergistic interaction of the PKCβ inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells in BRITISH JOURNAL OF CANCER
  • 2006-01. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival in BRITISH JOURNAL OF CANCER
  • 2008-06. Systemic Treatments for Mesothelioma: Standard and Novel in CURRENT TREATMENT OPTIONS IN ONCOLOGY
  • 2007-05. Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity in ONCOGENE
  • 2005-02. The expected burden of mesothelioma mortality in Great Britain from 2002 to 2050 in BRITISH JOURNAL OF CANCER
  • 2008-01. Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation in BRITISH JOURNAL OF CANCER
  • 2005-09. Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2011.400

    DOI

    http://dx.doi.org/10.1038/bjc.2011.400

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046093428

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21970874


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blotting, Western", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carboplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Screening Assays, Antitumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Synergism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme-Linked Immunosorbent Assay", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glutamates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Guanine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mesothelioma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pemetrexed", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Piperidines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pleural Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-akt", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quinazolines", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giovannetti", 
            "givenName": "E", 
            "id": "sg:person.0577505063.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577505063.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Humanitas Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417728.f", 
              "name": [
                "Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zucali", 
            "givenName": "P A", 
            "id": "sg:person.01276534213.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276534213.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technion \u2013 Israel Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.6451.6", 
              "name": [
                "Department of Biology, The Fred Wyszkowski Cancer Research Laboratory, Technion-Israel Institute of Technology, Haifa 32000, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Assaraf", 
            "givenName": "Y G", 
            "id": "sg:person.07355103674.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07355103674.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leon", 
            "givenName": "L G", 
            "id": "sg:person.0703774745.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703774745.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smid", 
            "givenName": "K", 
            "id": "sg:person.01232364243.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232364243.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alecci", 
            "givenName": "C", 
            "id": "sg:person.01253112137.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253112137.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giancola", 
            "givenName": "F", 
            "id": "sg:person.01204633354.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204633354.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Humanitas Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417728.f", 
              "name": [
                "Department of Human Pathology, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Destro", 
            "givenName": "A", 
            "id": "sg:person.0731244503.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731244503.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Humanitas Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417728.f", 
              "name": [
                "Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gianoncelli", 
            "givenName": "L", 
            "id": "sg:person.01341130645.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341130645.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Humanitas Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417728.f", 
              "name": [
                "Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lorenzi", 
            "givenName": "E", 
            "id": "sg:person.01112142446.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112142446.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Humanitas Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417728.f", 
              "name": [
                "Department of Human Pathology, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roncalli", 
            "givenName": "M", 
            "id": "sg:person.01003221003.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003221003.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Humanitas Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417728.f", 
              "name": [
                "Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Santoro", 
            "givenName": "A", 
            "id": "sg:person.01277354144.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277354144.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "G J", 
            "id": "sg:person.01255301342.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-2882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002360664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11864-008-0071-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002932855", 
              "https://doi.org/10.1007/s11864-008-0071-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003307358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003307358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.41.5869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003860266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-1940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005018109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005350243", 
              "https://doi.org/10.1038/sj.bjc.6605501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.107.042382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007890129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008790139", 
              "https://doi.org/10.1038/sj.bjc.6604134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2005.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010113049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-0833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010777456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2009.02.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011050621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdi557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011875003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.29.5717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013535496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.22.4279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015619833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019037719", 
              "https://doi.org/10.1038/sj.bjc.6604566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19960315)65:6<821::aid-ijc19>3.0.co;2-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021397877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-05-0446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023227064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdi910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023978758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024249456", 
              "https://doi.org/10.1038/nrclinonc.2009.38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024249456", 
              "https://doi.org/10.1038/nrclinonc.2009.38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0925-4439(02)00082-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026544769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029444767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.20.8977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029721897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-2923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029907598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-4926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030111330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2011.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030637222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2008.02.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034125139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035577810", 
              "https://doi.org/10.1038/sj.onc.1210129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035577810", 
              "https://doi.org/10.1038/sj.onc.1210129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-09-0665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035962589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-1539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036049860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037134578", 
              "https://doi.org/10.1186/1476-4598-9-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037761420", 
              "https://doi.org/10.1038/sj.onc.1208744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037761420", 
              "https://doi.org/10.1038/sj.onc.1208744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037761420", 
              "https://doi.org/10.1038/sj.onc.1208744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.04.3190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038621460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2011.07.073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040550333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-2318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041552171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041577731", 
              "https://doi.org/10.1038/sj.bjc.6602941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041577731", 
              "https://doi.org/10.1038/sj.bjc.6602941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cad.0000224457.36522.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041976244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cad.0000224457.36522.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041976244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-0328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042018418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.3138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042132070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2010.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043436361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-2952(97)00541-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043696467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.25.9275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043881557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.124.5.1916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044118143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgi312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045672291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-1698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047939317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-009-1195-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049610772", 
              "https://doi.org/10.1007/s00280-009-1195-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-009-1195-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049610772", 
              "https://doi.org/10.1007/s00280-009-1195-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051811900", 
              "https://doi.org/10.1038/sj.bjc.6602307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051811900", 
              "https://doi.org/10.1038/sj.bjc.6602307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.09.7634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052325568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.11.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v12.i11.1766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071364298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.25.5.1311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071515482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075266227", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076587292", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077320749", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083134319", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083295880", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-11", 
        "datePublishedReg": "2011-11-01", 
        "description": "BACKGROUND: Although pemetrexed, a potent thymidylate synthase (TS) inhibitor, enhances the cytoytoxic effect of platinum compounds against malignant pleural mesothelioma (MPM), novel combinations with effective targeted therapies are warranted. To this end, the current study evaluates new targeted agents and their pharmacological interaction with carboplatin-pemetrexed in human MPM cell lines.\nMETHODS: We treated H2052, H2452, H28 and MSTO-211H cells with carboplatin, pemetrexed and targeted compounds (gefitinib, erlotinib, sorafenib, vandetanib, enzastaurin and ZM447439) and evaluated the modulation of pivotal pathways in drug activity and cancer cell proliferation.\nRESULTS: Vandetanib emerged as the compound with the most potent cytotoxic activity, which interacted synergistically with carboplatin and pemetrexed. Drug combinations blocked Akt phosphorylation and increased apoptosis. Vandetanib significantly downregulated epidermal growth factor receptor (EGFR)/Erk/Akt phosphorylation as well as E2F-1 mRNA and TS mRNA/protein levels. Moreover, pemetrexed decreased Akt phosphorylation and expression of DNA repair genes. Finally, most MPM samples displayed detectable levels of EGFR and TS, the variability of which could be used for patients' stratification in future trials with vandetanib-pemetrexed-carboplatin combination.\nCONCLUSION: Vandetanib markedly enhances pemetrexed-carboplatin activity against human MPM cells. Induction of apoptosis, modulation of EGFR/Akt/Erk phosphorylation and expression of key determinants for pemetrexed and carboplatin activity contribute to this synergistic interaction, and, together with the expression of these determinants in MPM samples, warrant further clinical investigation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/bjc.2011.400", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1017082", 
            "issn": [
              "0007-0920", 
              "1532-1827"
            ], 
            "name": "British Journal of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "105"
          }
        ], 
        "name": "Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin", 
        "pagination": "1542", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "db90643988200a679f1508e631c53d51f8fe56585f307ee1763329333ed79157"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21970874"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0370635"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bjc.2011.400"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1046093428"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bjc.2011.400", 
          "https://app.dimensions.ai/details/publication/pub.1046093428"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/bjc2011400"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.400'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.400'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.400'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.400'


     

    This table displays all metadata directly associated to this object as RDF triples.

    415 TRIPLES      21 PREDICATES      105 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bjc.2011.400 schema:about N02434bb3aab2480d8b3c0990109b1332
    2 N118216c17e18426b90c1598a3c8ab8b7
    3 N206b1068dd6847808a270b1573b5e303
    4 N2376e4bcb2d24a179c6c1aef0530261a
    5 N240b655c473a49858006331b493bdb7c
    6 N26f162e72bb1426a8a151fdfb3f94d32
    7 N3123be270afb421fbd340928553e3be5
    8 N4410b9727eae447ca06267d9ecab9739
    9 N51e75bd2b78c484fb174c5e7e2f5a502
    10 N53dcfa0ae97d4ec587a31d27fbc14920
    11 N5e67d6b41d56402d80640d73a2ebe16b
    12 N634e79d7a2334cda9dfc1cb2b9685a5f
    13 N8389906b2454436081abfcc37d4fa470
    14 N8d306cf79fc444b5a9c3896bfe1619ab
    15 Nc5de13a6dc994c95975ef6d5c62bc288
    16 Nd48c778d69154e789d4cab2568577956
    17 Ndd02950b1e92404aa81701f5cbfc8708
    18 Ne31d8145cbf8429e9e1d1828e64d6f5a
    19 Neeb3ae1d0c5947fc88fa0376517e2de5
    20 Nf9ed4a5a0b1944a3974d9495bf14a703
    21 Nfb99f13420bd4054b609a0a1af9a80c4
    22 anzsrc-for:06
    23 anzsrc-for:0601
    24 schema:author N4be921c9f96d40eb8b614179f4c954c2
    25 schema:citation sg:pub.10.1007/s00280-009-1195-2
    26 sg:pub.10.1007/s11864-008-0071-3
    27 sg:pub.10.1038/nrclinonc.2009.38
    28 sg:pub.10.1038/sj.bjc.6602307
    29 sg:pub.10.1038/sj.bjc.6602941
    30 sg:pub.10.1038/sj.bjc.6604134
    31 sg:pub.10.1038/sj.bjc.6604566
    32 sg:pub.10.1038/sj.bjc.6605501
    33 sg:pub.10.1038/sj.onc.1208744
    34 sg:pub.10.1038/sj.onc.1210129
    35 sg:pub.10.1186/1476-4598-9-27
    36 https://app.dimensions.ai/details/publication/pub.1075266227
    37 https://app.dimensions.ai/details/publication/pub.1076587292
    38 https://app.dimensions.ai/details/publication/pub.1077320749
    39 https://app.dimensions.ai/details/publication/pub.1083134319
    40 https://app.dimensions.ai/details/publication/pub.1083295880
    41 https://doi.org/10.1002/(sici)1097-0215(19960315)65:6<821::aid-ijc19>3.0.co;2-6
    42 https://doi.org/10.1002/ijc.21290
    43 https://doi.org/10.1016/j.bcp.2011.07.073
    44 https://doi.org/10.1016/j.canlet.2008.02.018
    45 https://doi.org/10.1016/j.ctrv.2011.01.001
    46 https://doi.org/10.1016/j.ejca.2009.02.022
    47 https://doi.org/10.1016/j.lungcan.2005.10.016
    48 https://doi.org/10.1016/j.lungcan.2010.01.002
    49 https://doi.org/10.1016/s0006-2952(97)00541-8
    50 https://doi.org/10.1016/s0925-4439(02)00082-0
    51 https://doi.org/10.1073/pnas.88.20.8977
    52 https://doi.org/10.1093/annonc/mdi557
    53 https://doi.org/10.1093/annonc/mdi910
    54 https://doi.org/10.1093/carcin/bgi312
    55 https://doi.org/10.1097/01.cad.0000224457.36522.60
    56 https://doi.org/10.1124/mol.107.042382
    57 https://doi.org/10.1158/0008-5472.can-05-1698
    58 https://doi.org/10.1158/0008-5472.can-05-2882
    59 https://doi.org/10.1158/0008-5472.can-06-2318
    60 https://doi.org/10.1158/1078-0432.ccr-04-1940
    61 https://doi.org/10.1158/1078-0432.ccr-05-0328
    62 https://doi.org/10.1158/1078-0432.ccr-06-0833
    63 https://doi.org/10.1158/1078-0432.ccr-06-2923
    64 https://doi.org/10.1158/1078-0432.ccr-07-1539
    65 https://doi.org/10.1158/1078-0432.ccr-07-4926
    66 https://doi.org/10.1158/1078-0432.ccr-10-2873
    67 https://doi.org/10.1158/1535-7163.mct-05-0446
    68 https://doi.org/10.1158/1535-7163.mct-09-0665
    69 https://doi.org/10.1200/jco.2003.11.136
    70 https://doi.org/10.1200/jco.2005.04.3190
    71 https://doi.org/10.1200/jco.2006.09.7634
    72 https://doi.org/10.1200/jco.2008.17.3138
    73 https://doi.org/10.1200/jco.2009.22.4279
    74 https://doi.org/10.1200/jco.2009.25.9275
    75 https://doi.org/10.1200/jco.2010.29.5717
    76 https://doi.org/10.1200/jco.2011.41.5869
    77 https://doi.org/10.1378/chest.124.5.1916
    78 https://doi.org/10.3748/wjg.v12.i11.1766
    79 https://doi.org/10.3892/ijo.25.5.1311
    80 schema:datePublished 2011-11
    81 schema:datePublishedReg 2011-11-01
    82 schema:description BACKGROUND: Although pemetrexed, a potent thymidylate synthase (TS) inhibitor, enhances the cytoytoxic effect of platinum compounds against malignant pleural mesothelioma (MPM), novel combinations with effective targeted therapies are warranted. To this end, the current study evaluates new targeted agents and their pharmacological interaction with carboplatin-pemetrexed in human MPM cell lines. METHODS: We treated H2052, H2452, H28 and MSTO-211H cells with carboplatin, pemetrexed and targeted compounds (gefitinib, erlotinib, sorafenib, vandetanib, enzastaurin and ZM447439) and evaluated the modulation of pivotal pathways in drug activity and cancer cell proliferation. RESULTS: Vandetanib emerged as the compound with the most potent cytotoxic activity, which interacted synergistically with carboplatin and pemetrexed. Drug combinations blocked Akt phosphorylation and increased apoptosis. Vandetanib significantly downregulated epidermal growth factor receptor (EGFR)/Erk/Akt phosphorylation as well as E2F-1 mRNA and TS mRNA/protein levels. Moreover, pemetrexed decreased Akt phosphorylation and expression of DNA repair genes. Finally, most MPM samples displayed detectable levels of EGFR and TS, the variability of which could be used for patients' stratification in future trials with vandetanib-pemetrexed-carboplatin combination. CONCLUSION: Vandetanib markedly enhances pemetrexed-carboplatin activity against human MPM cells. Induction of apoptosis, modulation of EGFR/Akt/Erk phosphorylation and expression of key determinants for pemetrexed and carboplatin activity contribute to this synergistic interaction, and, together with the expression of these determinants in MPM samples, warrant further clinical investigation.
    83 schema:genre research_article
    84 schema:inLanguage en
    85 schema:isAccessibleForFree true
    86 schema:isPartOf N846ca1d09bc54dc08066f29a01c589c6
    87 Nbe40feb6760442dbbb04c9acdeac6267
    88 sg:journal.1017082
    89 schema:name Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin
    90 schema:pagination 1542
    91 schema:productId N759e483eecfd4062a1e2b67ee0feadc7
    92 N89231f4a17e447ea8fd9c1ca21f14814
    93 N8cfdfd703a724ac98507e0dbb73e8247
    94 Na809d4aae9214f4aae27b5f6c1b51eee
    95 Nddbb9112a27d4435807c98d1db831a42
    96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046093428
    97 https://doi.org/10.1038/bjc.2011.400
    98 schema:sdDatePublished 2019-04-10T21:25
    99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    100 schema:sdPublisher N6792fc1b35664843a85fd0a40ffbae56
    101 schema:url https://www.nature.com/articles/bjc2011400
    102 sgo:license sg:explorer/license/
    103 sgo:sdDataset articles
    104 rdf:type schema:ScholarlyArticle
    105 N02434bb3aab2480d8b3c0990109b1332 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Phosphorylation
    107 rdf:type schema:DefinedTerm
    108 N0e24eb4285fb49fcb704fb3858095ed5 rdf:first sg:person.01255301342.17
    109 rdf:rest rdf:nil
    110 N118216c17e18426b90c1598a3c8ab8b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Carboplatin
    112 rdf:type schema:DefinedTerm
    113 N1d32a883a8ce4c89b99fee0fa671b2c6 rdf:first sg:person.01204633354.08
    114 rdf:rest Ne537ce9d30504f0dad0721fcae11f336
    115 N206b1068dd6847808a270b1573b5e303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Cell Line, Tumor
    117 rdf:type schema:DefinedTerm
    118 N2376e4bcb2d24a179c6c1aef0530261a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Drug Screening Assays, Antitumor
    120 rdf:type schema:DefinedTerm
    121 N240b655c473a49858006331b493bdb7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Quinazolines
    123 rdf:type schema:DefinedTerm
    124 N26f162e72bb1426a8a151fdfb3f94d32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Pleural Neoplasms
    126 rdf:type schema:DefinedTerm
    127 N3123be270afb421fbd340928553e3be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Guanine
    129 rdf:type schema:DefinedTerm
    130 N4410b9727eae447ca06267d9ecab9739 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Piperidines
    132 rdf:type schema:DefinedTerm
    133 N4a7930aaa67f44a798ed6cd0b2f58011 rdf:first sg:person.01003221003.31
    134 rdf:rest Nf0f290a8240b494e823b4be819f26c06
    135 N4be921c9f96d40eb8b614179f4c954c2 rdf:first sg:person.0577505063.56
    136 rdf:rest N9eeb7a42430d4e77ae87a194edc1c48d
    137 N51e75bd2b78c484fb174c5e7e2f5a502 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Proto-Oncogene Proteins c-akt
    139 rdf:type schema:DefinedTerm
    140 N53dcfa0ae97d4ec587a31d27fbc14920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Polymorphism, Genetic
    142 rdf:type schema:DefinedTerm
    143 N5e1bf39af9144750a786b59e3eb44e44 rdf:first sg:person.0703774745.29
    144 rdf:rest N8cecd9bd8b4c4f5e92bf83bbe6e6a632
    145 N5e67d6b41d56402d80640d73a2ebe16b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Cell Cycle
    147 rdf:type schema:DefinedTerm
    148 N627bc519b46b411c8b1e40dd30820725 rdf:first sg:person.07355103674.46
    149 rdf:rest N5e1bf39af9144750a786b59e3eb44e44
    150 N634e79d7a2334cda9dfc1cb2b9685a5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Enzyme-Linked Immunosorbent Assay
    152 rdf:type schema:DefinedTerm
    153 N6792fc1b35664843a85fd0a40ffbae56 schema:name Springer Nature - SN SciGraph project
    154 rdf:type schema:Organization
    155 N6df767f3c7e9436888952080aa5c35a8 rdf:first sg:person.01112142446.76
    156 rdf:rest N4a7930aaa67f44a798ed6cd0b2f58011
    157 N759e483eecfd4062a1e2b67ee0feadc7 schema:name doi
    158 schema:value 10.1038/bjc.2011.400
    159 rdf:type schema:PropertyValue
    160 N8389906b2454436081abfcc37d4fa470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Apoptosis
    162 rdf:type schema:DefinedTerm
    163 N846ca1d09bc54dc08066f29a01c589c6 schema:issueNumber 10
    164 rdf:type schema:PublicationIssue
    165 N89231f4a17e447ea8fd9c1ca21f14814 schema:name pubmed_id
    166 schema:value 21970874
    167 rdf:type schema:PropertyValue
    168 N8cecd9bd8b4c4f5e92bf83bbe6e6a632 rdf:first sg:person.01232364243.35
    169 rdf:rest N8d97afa04e5e469ab3fb0631b9dbd531
    170 N8cfdfd703a724ac98507e0dbb73e8247 schema:name nlm_unique_id
    171 schema:value 0370635
    172 rdf:type schema:PropertyValue
    173 N8d306cf79fc444b5a9c3896bfe1619ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Immunohistochemistry
    175 rdf:type schema:DefinedTerm
    176 N8d97afa04e5e469ab3fb0631b9dbd531 rdf:first sg:person.01253112137.73
    177 rdf:rest N1d32a883a8ce4c89b99fee0fa671b2c6
    178 N9eeb7a42430d4e77ae87a194edc1c48d rdf:first sg:person.01276534213.53
    179 rdf:rest N627bc519b46b411c8b1e40dd30820725
    180 Na809d4aae9214f4aae27b5f6c1b51eee schema:name readcube_id
    181 schema:value db90643988200a679f1508e631c53d51f8fe56585f307ee1763329333ed79157
    182 rdf:type schema:PropertyValue
    183 Nbe40feb6760442dbbb04c9acdeac6267 schema:volumeNumber 105
    184 rdf:type schema:PublicationVolume
    185 Nc5de13a6dc994c95975ef6d5c62bc288 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Blotting, Western
    187 rdf:type schema:DefinedTerm
    188 Nd48c778d69154e789d4cab2568577956 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Mesothelioma
    190 rdf:type schema:DefinedTerm
    191 Ndd02950b1e92404aa81701f5cbfc8708 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Polymerase Chain Reaction
    193 rdf:type schema:DefinedTerm
    194 Nddbb9112a27d4435807c98d1db831a42 schema:name dimensions_id
    195 schema:value pub.1046093428
    196 rdf:type schema:PropertyValue
    197 Ne31d8145cbf8429e9e1d1828e64d6f5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Humans
    199 rdf:type schema:DefinedTerm
    200 Ne537ce9d30504f0dad0721fcae11f336 rdf:first sg:person.0731244503.36
    201 rdf:rest Nf8195d9795484b0f875296166308d491
    202 Neeb3ae1d0c5947fc88fa0376517e2de5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Glutamates
    204 rdf:type schema:DefinedTerm
    205 Nf0f290a8240b494e823b4be819f26c06 rdf:first sg:person.01277354144.26
    206 rdf:rest N0e24eb4285fb49fcb704fb3858095ed5
    207 Nf8195d9795484b0f875296166308d491 rdf:first sg:person.01341130645.45
    208 rdf:rest N6df767f3c7e9436888952080aa5c35a8
    209 Nf9ed4a5a0b1944a3974d9495bf14a703 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Drug Synergism
    211 rdf:type schema:DefinedTerm
    212 Nfb99f13420bd4054b609a0a1af9a80c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Pemetrexed
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Biological Sciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Biochemistry and Cell Biology
    220 rdf:type schema:DefinedTerm
    221 sg:journal.1017082 schema:issn 0007-0920
    222 1532-1827
    223 schema:name British Journal of Cancer
    224 rdf:type schema:Periodical
    225 sg:person.01003221003.31 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
    226 schema:familyName Roncalli
    227 schema:givenName M
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003221003.31
    229 rdf:type schema:Person
    230 sg:person.01112142446.76 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
    231 schema:familyName Lorenzi
    232 schema:givenName E
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112142446.76
    234 rdf:type schema:Person
    235 sg:person.01204633354.08 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    236 schema:familyName Giancola
    237 schema:givenName F
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204633354.08
    239 rdf:type schema:Person
    240 sg:person.01232364243.35 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    241 schema:familyName Smid
    242 schema:givenName K
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232364243.35
    244 rdf:type schema:Person
    245 sg:person.01253112137.73 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    246 schema:familyName Alecci
    247 schema:givenName C
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253112137.73
    249 rdf:type schema:Person
    250 sg:person.01255301342.17 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    251 schema:familyName Peters
    252 schema:givenName G J
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17
    254 rdf:type schema:Person
    255 sg:person.01276534213.53 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
    256 schema:familyName Zucali
    257 schema:givenName P A
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276534213.53
    259 rdf:type schema:Person
    260 sg:person.01277354144.26 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
    261 schema:familyName Santoro
    262 schema:givenName A
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277354144.26
    264 rdf:type schema:Person
    265 sg:person.01341130645.45 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
    266 schema:familyName Gianoncelli
    267 schema:givenName L
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341130645.45
    269 rdf:type schema:Person
    270 sg:person.0577505063.56 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    271 schema:familyName Giovannetti
    272 schema:givenName E
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577505063.56
    274 rdf:type schema:Person
    275 sg:person.0703774745.29 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    276 schema:familyName Leon
    277 schema:givenName L G
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703774745.29
    279 rdf:type schema:Person
    280 sg:person.0731244503.36 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
    281 schema:familyName Destro
    282 schema:givenName A
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731244503.36
    284 rdf:type schema:Person
    285 sg:person.07355103674.46 schema:affiliation https://www.grid.ac/institutes/grid.6451.6
    286 schema:familyName Assaraf
    287 schema:givenName Y G
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07355103674.46
    289 rdf:type schema:Person
    290 sg:pub.10.1007/s00280-009-1195-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049610772
    291 https://doi.org/10.1007/s00280-009-1195-2
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s11864-008-0071-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002932855
    294 https://doi.org/10.1007/s11864-008-0071-3
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nrclinonc.2009.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024249456
    297 https://doi.org/10.1038/nrclinonc.2009.38
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/sj.bjc.6602307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051811900
    300 https://doi.org/10.1038/sj.bjc.6602307
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/sj.bjc.6602941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041577731
    303 https://doi.org/10.1038/sj.bjc.6602941
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/sj.bjc.6604134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008790139
    306 https://doi.org/10.1038/sj.bjc.6604134
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/sj.bjc.6604566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019037719
    309 https://doi.org/10.1038/sj.bjc.6604566
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/sj.bjc.6605501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005350243
    312 https://doi.org/10.1038/sj.bjc.6605501
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/sj.onc.1208744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037761420
    315 https://doi.org/10.1038/sj.onc.1208744
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/sj.onc.1210129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035577810
    318 https://doi.org/10.1038/sj.onc.1210129
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1186/1476-4598-9-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037134578
    321 https://doi.org/10.1186/1476-4598-9-27
    322 rdf:type schema:CreativeWork
    323 https://app.dimensions.ai/details/publication/pub.1075266227 schema:CreativeWork
    324 https://app.dimensions.ai/details/publication/pub.1076587292 schema:CreativeWork
    325 https://app.dimensions.ai/details/publication/pub.1077320749 schema:CreativeWork
    326 https://app.dimensions.ai/details/publication/pub.1083134319 schema:CreativeWork
    327 https://app.dimensions.ai/details/publication/pub.1083295880 schema:CreativeWork
    328 https://doi.org/10.1002/(sici)1097-0215(19960315)65:6<821::aid-ijc19>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021397877
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1002/ijc.21290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003307358
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/j.bcp.2011.07.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040550333
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/j.canlet.2008.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034125139
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/j.ctrv.2011.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030637222
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/j.ejca.2009.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011050621
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/j.lungcan.2005.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010113049
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1016/j.lungcan.2010.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043436361
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1016/s0006-2952(97)00541-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043696467
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/s0925-4439(02)00082-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026544769
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1073/pnas.88.20.8977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029721897
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/annonc/mdi557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011875003
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1093/annonc/mdi910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023978758
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1093/carcin/bgi312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045672291
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1097/01.cad.0000224457.36522.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041976244
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1124/mol.107.042382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007890129
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1158/0008-5472.can-05-1698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047939317
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1158/0008-5472.can-05-2882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002360664
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1158/0008-5472.can-06-2318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041552171
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1158/1078-0432.ccr-04-1940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005018109
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1158/1078-0432.ccr-05-0328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042018418
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1158/1078-0432.ccr-06-0833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010777456
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1158/1078-0432.ccr-06-2923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029907598
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1158/1078-0432.ccr-07-1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036049860
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1158/1078-0432.ccr-07-4926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030111330
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1158/1078-0432.ccr-10-2873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029444767
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1158/1535-7163.mct-05-0446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023227064
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1158/1535-7163.mct-09-0665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035962589
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1200/jco.2003.11.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203976
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1200/jco.2005.04.3190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038621460
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1200/jco.2006.09.7634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052325568
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1200/jco.2008.17.3138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042132070
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1200/jco.2009.22.4279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015619833
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1200/jco.2009.25.9275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043881557
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1200/jco.2010.29.5717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013535496
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1200/jco.2011.41.5869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003860266
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1378/chest.124.5.1916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044118143
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.3748/wjg.v12.i11.1766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071364298
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.3892/ijo.25.5.1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071515482
    405 rdf:type schema:CreativeWork
    406 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    407 schema:name Department of Medical Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands
    408 rdf:type schema:Organization
    409 https://www.grid.ac/institutes/grid.417728.f schema:alternateName Humanitas Research Hospital
    410 schema:name Department of Human Pathology, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    411 Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Italy
    412 rdf:type schema:Organization
    413 https://www.grid.ac/institutes/grid.6451.6 schema:alternateName Technion – Israel Institute of Technology
    414 schema:name Department of Biology, The Fred Wyszkowski Cancer Research Laboratory, Technion-Israel Institute of Technology, Haifa 32000, Israel
    415 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...