Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09-27

AUTHORS

A Zeleniuch-Jacquotte, R E Shore, Y Afanasyeva, A Lukanova, S Sieri, K L Koenig, A Idahl, V Krogh, M Liu, N Ohlson, P Muti, A A Arslan, P Lenner, F Berrino, G Hallmans, P Toniolo, E Lundin

ABSTRACT

Background:It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.Methods:We conducted a case–control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with endometrial cancer risk in postmenopausal women. A total of 179 cases and 336 controls, matching cases on cohort, age and date of blood donation, were included. Levels of 2-OHE1 and 16α-OHE1 were measured using a monoclonal antibody-based enzyme assay.Results:Endometrial cancer risk increased with increasing levels of both metabolites, with odds ratios in the top tertiles of 2.4 (95% CI=1.3, 4.6; Ptrend=0.007) for 2-OHE1 and 1.9 (95% CI=1.1, 3.5; Ptrend=0.03) for 16α-OHE1 in analyses adjusting for endometrial cancer risk factors. These associations were attenuated and no longer statistically significant after further adjustment for oestrone or oestradiol levels. No significant association was observed for the 2-OHE1 : 16α-OHE1 ratio.Conclusion:Our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer. More... »

PAGES

1458-1464

Journal

TITLE

British Journal of Cancer

ISSUE

9

VOLUME

105

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2011.381

DOI

http://dx.doi.org/10.1038/bjc.2011.381

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018706864

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21952628


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