Expression and functional role of CRIPTO-1 in cutaneous melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09

AUTHORS

A De Luca, L Lamura, L Strizzi, C Roma, A D'Antonio, N Margaryan, G Pirozzi, M-Y Hsu, G Botti, E Mari, M J C Hendrix, D S Salomon, N Normanno

ABSTRACT

BACKGROUND: CRIPTO-1 (CR-1) is involved in the pathogenesis and progression of human carcinoma of different histological origin. In this study we addressed the expression and the functional role of CR-1 in cutaneous melanoma. METHODS: Expression of CR-1 protein in melanomas and melanoma cell lines was assessed by immunohistochemistry, western blotting and/or flow cytometry. Levels of mRNA were evaluated by real-time PCR. Invasion assays were performed in Matrigel-coated modified Boyden chambers. RESULTS: Expression of CR-1 protein and/or mRNA was found in 16 out of 37 primary human cutaneous melanomas and in 12 out of 21 melanoma cell lines. Recombinant CR-1 protein activated in melanoma cells c-Src and, at lesser extent, Smad signalling. In addition, CR-1 significantly increased the invasive ability of melanoma cells that was prevented by treatment with either the ALK4 inhibitor SB-431542 or the c-Src inhibitor saracatinib (AZD0530). Anti-CR-1 siRNAs produced a significant inhibition of the growth and the invasive ability of melanoma cells. Finally, a close correlation was found in melanoma cells between the levels of expression of CR-1 and the effects of saracatinib on cell growth. CONCLUSION: These data indicate that a significant fraction of cutaneous melanoma expresses CR-1 and that this growth factor is involved in the invasion and proliferation of melanoma cells. More... »

PAGES

1030

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2011.324

DOI

http://dx.doi.org/10.1038/bjc.2011.324

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028873662

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21863025


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Activin Receptors, Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzodioxoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dioxoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GPI-Linked Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smad Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src-Family Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Cell Biology and Biotherapy Unit, Research Department, INT-Fondazione Pascale, Naples 80131, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Luca", 
        "givenName": "A", 
        "id": "sg:person.0674373366.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674373366.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Cell Biology and Biotherapy Unit, Research Department, INT-Fondazione Pascale, Naples 80131, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamura", 
        "givenName": "L", 
        "id": "sg:person.01300115125.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300115125.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lurie Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413808.6", 
          "name": [
            "Children's Memorial Research Center, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614-4314, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strizzi", 
        "givenName": "L", 
        "id": "sg:person.01071726627.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071726627.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratory of Pharmacogenomic, Centro di Ricerche Oncologiche di Mercogliano\u2013CROM, Mercogliano (AV) 83013, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roma", 
        "givenName": "C", 
        "id": "sg:person.01362313740.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362313740.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pathology Unit, S. Giovanni di Dio e Ruggi d\u2019Aragona Hospital, Salerno 84100, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D'Antonio", 
        "givenName": "A", 
        "id": "sg:person.01173201114.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173201114.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lurie Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413808.6", 
          "name": [
            "Children's Memorial Research Center, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614-4314, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Margaryan", 
        "givenName": "N", 
        "id": "sg:person.0714701423.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714701423.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Cell Biology and Biotherapy Unit, Research Department, INT-Fondazione Pascale, Naples 80131, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pirozzi", 
        "givenName": "G", 
        "id": "sg:person.01337142666.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337142666.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University School of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.475010.7", 
          "name": [
            "Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "M-Y", 
        "id": "sg:person.01254045424.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254045424.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Pathology Unit, INT-Fondazione Pascale, Naples 80131, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Botti", 
        "givenName": "G", 
        "id": "sg:person.01142725140.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142725140.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (Italy)", 
          "id": "https://www.grid.ac/institutes/grid.476012.6", 
          "name": [
            "AstraZeneca, Basiglio (MI) 20080, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mari", 
        "givenName": "E", 
        "id": "sg:person.0663545617.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663545617.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lurie Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413808.6", 
          "name": [
            "Children's Memorial Research Center, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614-4314, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hendrix", 
        "givenName": "M J C", 
        "id": "sg:person.01031130023.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031130023.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salomon", 
        "givenName": "D S", 
        "id": "sg:person.0712117565.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712117565.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Cell Biology and Biotherapy Unit, Research Department, INT-Fondazione Pascale, Naples 80131, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Normanno", 
        "givenName": "N", 
        "id": "sg:person.01353442665.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353442665.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00249-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01168-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001777226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003862661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-6-53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006414800", 
          "https://doi.org/10.1186/1479-5876-6-53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0070-2153(05)67003-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008400474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0070-2153(05)67003-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008400474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63000-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012111147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012263251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/17469872.4.1.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012348396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014860210", 
          "https://doi.org/10.1038/sj.onc.1205859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014860210", 
          "https://doi.org/10.1038/sj.onc.1205859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exer.2007.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015179936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021487923", 
          "https://doi.org/10.1038/nature05661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021581886", 
          "https://doi.org/10.1038/nm1448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021581886", 
          "https://doi.org/10.1038/nm1448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e05-10-0927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022708759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci17788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024373547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.10375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028981370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031787297", 
          "https://doi.org/10.1038/sj.onc.1208417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031787297", 
          "https://doi.org/10.1038/sj.onc.1208417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031787297", 
          "https://doi.org/10.1038/sj.onc.1208417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.201801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031884983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0800467105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033904137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1478-811x-7-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034223270", 
          "https://doi.org/10.1186/1478-811x-7-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/88.7.419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036926193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra052166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037124002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e328304974c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037140481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e328304974c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037140481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e328304974c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037140481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.8.2586-2597.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038693082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<589::aid-ijc17>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041394981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041811648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728222.11.1.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041884182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048424447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048424447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-08-0169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049231349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049663453", 
          "https://doi.org/10.1038/sj.onc.1208918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049663453", 
          "https://doi.org/10.1038/sj.onc.1208918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049663453", 
          "https://doi.org/10.1038/sj.onc.1208918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050525398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051921823", 
          "https://doi.org/10.1038/sj.onc.1203979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051921823", 
          "https://doi.org/10.1038/sj.onc.1203979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/12.6.787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052371082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.1165027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062681778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/normano", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070918293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.21.5.941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.7.13.6236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072299538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075255974", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076893883", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077645852", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078189938", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078824787", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082467183", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082747058", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-09", 
    "datePublishedReg": "2011-09-01", 
    "description": "BACKGROUND: CRIPTO-1 (CR-1) is involved in the pathogenesis and progression of human carcinoma of different histological origin. In this study we addressed the expression and the functional role of CR-1 in cutaneous melanoma.\nMETHODS: Expression of CR-1 protein in melanomas and melanoma cell lines was assessed by immunohistochemistry, western blotting and/or flow cytometry. Levels of mRNA were evaluated by real-time PCR. Invasion assays were performed in Matrigel-coated modified Boyden chambers.\nRESULTS: Expression of CR-1 protein and/or mRNA was found in 16 out of 37 primary human cutaneous melanomas and in 12 out of 21 melanoma cell lines. Recombinant CR-1 protein activated in melanoma cells c-Src and, at lesser extent, Smad signalling. In addition, CR-1 significantly increased the invasive ability of melanoma cells that was prevented by treatment with either the ALK4 inhibitor SB-431542 or the c-Src inhibitor saracatinib (AZD0530). Anti-CR-1 siRNAs produced a significant inhibition of the growth and the invasive ability of melanoma cells. Finally, a close correlation was found in melanoma cells between the levels of expression of CR-1 and the effects of saracatinib on cell growth.\nCONCLUSION: These data indicate that a significant fraction of cutaneous melanoma expresses CR-1 and that this growth factor is involved in the invasion and proliferation of melanoma cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2011.324", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2478788", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "105"
      }
    ], 
    "name": "Expression and functional role of CRIPTO-1 in cutaneous melanoma", 
    "pagination": "1030", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "898c2792192a4268bd048d164f6d31e2ea79c74109d8dc59808c94b64dead4c5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21863025"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2011.324"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028873662"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2011.324", 
      "https://app.dimensions.ai/details/publication/pub.1028873662"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2011324"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.324'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.324'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.324'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2011.324'


 

This table displays all metadata directly associated to this object as RDF triples.

402 TRIPLES      21 PREDICATES      97 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2011.324 schema:about N0ec6a0e32b794475b3cd699e13012892
2 N17533fce3d9d4176986640feea57d5e6
3 N18f5e3b0de2c4a278133b689c412d8e2
4 N1b0a31ecd2c541be9e16a322215352ae
5 N26dbfed1210941d58879bf73a8bd17eb
6 N28658fbb50bf4941b29c39c5d9c1e887
7 N3666b65894af4f9caabbee9ec784bcca
8 N521c31955c37474c99514da9a571d203
9 N603d5f3a8bfb4be38bd57368d578233f
10 N7a7230e4e7a74f3eb1694fd70499dbb4
11 N7fd7c3638a9b48b99d23156f7a495df3
12 N837762f91c344cd4a8198e1bbe017603
13 N8b308313dcc14778b5847bb5daee95a0
14 N99c83779a8ef4d849985e842ff5ebcd1
15 Nb040967fc3684ed282fd3dc27de9e5f4
16 Nb3c1c981d9ff4c80bf47e887c786fd3d
17 Nb52cda59067f400388202f85f0b1a8a4
18 Nba76988da78d45a4bf9fd2b19877d677
19 Nc3c262ac8ec24a6e9a9352a1083ef1fe
20 Nc47b066863754f0a8892b372469439de
21 Nd912f3f20f184ed89afd4c0a17dc1046
22 Nda7f640e573e4a92a509ecfe0b8c4d3d
23 Ndbe862b057c34dcd96994f12333c0476
24 Nde4e982748cb4bacaa8b95a7e788ff5a
25 Nfdba0909e21941228670949edba29bef
26 anzsrc-for:11
27 anzsrc-for:1112
28 schema:author N4ebcfe29823b45619bce9a8ea5545d17
29 schema:citation sg:pub.10.1038/nature05661
30 sg:pub.10.1038/nm1448
31 sg:pub.10.1038/sj.onc.1203979
32 sg:pub.10.1038/sj.onc.1205859
33 sg:pub.10.1038/sj.onc.1208417
34 sg:pub.10.1038/sj.onc.1208918
35 sg:pub.10.1186/1478-811x-7-10
36 sg:pub.10.1186/1479-5876-6-53
37 https://app.dimensions.ai/details/publication/pub.1075255974
38 https://app.dimensions.ai/details/publication/pub.1076893883
39 https://app.dimensions.ai/details/publication/pub.1077645852
40 https://app.dimensions.ai/details/publication/pub.1078189938
41 https://app.dimensions.ai/details/publication/pub.1078824787
42 https://app.dimensions.ai/details/publication/pub.1082467183
43 https://app.dimensions.ai/details/publication/pub.1082747058
44 https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<589::aid-ijc17>3.0.co;2-d
45 https://doi.org/10.1002/jcp.10375
46 https://doi.org/10.1002/jcp.20588
47 https://doi.org/10.1002/path.2083
48 https://doi.org/10.1016/j.exer.2007.01.019
49 https://doi.org/10.1016/s0002-9440(10)63000-3
50 https://doi.org/10.1016/s0070-2153(05)67003-2
51 https://doi.org/10.1016/s1097-2765(01)00249-0
52 https://doi.org/10.1038/emboj.2008.174
53 https://doi.org/10.1056/nejmra052166
54 https://doi.org/10.1073/pnas.0800467105
55 https://doi.org/10.1091/mbc.e05-10-0927
56 https://doi.org/10.1093/intimm/12.6.787
57 https://doi.org/10.1093/jnci/88.7.419
58 https://doi.org/10.1097/cmr.0b013e328304974c
59 https://doi.org/10.1101/gad.201801
60 https://doi.org/10.1126/scisignal.1165027
61 https://doi.org/10.1128/mcb.01168-06
62 https://doi.org/10.1128/mcb.22.8.2586-2597.2002
63 https://doi.org/10.1158/0008-5472.can-03-3888
64 https://doi.org/10.1158/1078-0432.ccr-05-1940
65 https://doi.org/10.1158/1541-7786.mcr-08-0169
66 https://doi.org/10.1172/jci17788
67 https://doi.org/10.1517/14728222.11.1.91
68 https://doi.org/10.1586/17469872.4.1.67
69 https://doi.org/10.2741/normano
70 https://doi.org/10.3892/ijo.21.5.941
71 https://doi.org/10.4161/cc.7.13.6236
72 schema:datePublished 2011-09
73 schema:datePublishedReg 2011-09-01
74 schema:description BACKGROUND: CRIPTO-1 (CR-1) is involved in the pathogenesis and progression of human carcinoma of different histological origin. In this study we addressed the expression and the functional role of CR-1 in cutaneous melanoma. METHODS: Expression of CR-1 protein in melanomas and melanoma cell lines was assessed by immunohistochemistry, western blotting and/or flow cytometry. Levels of mRNA were evaluated by real-time PCR. Invasion assays were performed in Matrigel-coated modified Boyden chambers. RESULTS: Expression of CR-1 protein and/or mRNA was found in 16 out of 37 primary human cutaneous melanomas and in 12 out of 21 melanoma cell lines. Recombinant CR-1 protein activated in melanoma cells c-Src and, at lesser extent, Smad signalling. In addition, CR-1 significantly increased the invasive ability of melanoma cells that was prevented by treatment with either the ALK4 inhibitor SB-431542 or the c-Src inhibitor saracatinib (AZD0530). Anti-CR-1 siRNAs produced a significant inhibition of the growth and the invasive ability of melanoma cells. Finally, a close correlation was found in melanoma cells between the levels of expression of CR-1 and the effects of saracatinib on cell growth. CONCLUSION: These data indicate that a significant fraction of cutaneous melanoma expresses CR-1 and that this growth factor is involved in the invasion and proliferation of melanoma cells.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N258bd42a972348f6a5894a829c70efb4
79 Nb6793c8b93624188bd6fda792790ee5a
80 sg:journal.1017082
81 schema:name Expression and functional role of CRIPTO-1 in cutaneous melanoma
82 schema:pagination 1030
83 schema:productId N0281283e840f4689b2d11b16da634281
84 N09610e2a8ce14fbe8b893868abff5551
85 N2cc9376a4f7e4c05a7cc820569b7bf03
86 N74446ab55adf45e0a825b766bcd3f1f5
87 Nff98c41ab4214b298bc2cc5f652d1765
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028873662
89 https://doi.org/10.1038/bjc.2011.324
90 schema:sdDatePublished 2019-04-10T19:46
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Ncf93099ad8204455be728acf21cc9f1f
93 schema:url https://www.nature.com/articles/bjc2011324
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0281283e840f4689b2d11b16da634281 schema:name pubmed_id
98 schema:value 21863025
99 rdf:type schema:PropertyValue
100 N05640ec543d849f4ba20399c93121112 schema:name Pathology Unit, S. Giovanni di Dio e Ruggi d’Aragona Hospital, Salerno 84100, Italy
101 rdf:type schema:Organization
102 N09610e2a8ce14fbe8b893868abff5551 schema:name doi
103 schema:value 10.1038/bjc.2011.324
104 rdf:type schema:PropertyValue
105 N0ec6a0e32b794475b3cd699e13012892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N17533fce3d9d4176986640feea57d5e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Protein-Tyrosine Kinases
110 rdf:type schema:DefinedTerm
111 N18f5e3b0de2c4a278133b689c412d8e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name RNA, Small Interfering
113 rdf:type schema:DefinedTerm
114 N1b0a31ecd2c541be9e16a322215352ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Blotting, Western
116 rdf:type schema:DefinedTerm
117 N1bffde03773543c7a2522e7b580ede27 rdf:first sg:person.01353442665.26
118 rdf:rest rdf:nil
119 N258bd42a972348f6a5894a829c70efb4 schema:volumeNumber 105
120 rdf:type schema:PublicationVolume
121 N26dbfed1210941d58879bf73a8bd17eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Immunoenzyme Techniques
123 rdf:type schema:DefinedTerm
124 N28440e31756848ce9df5e2f36d2d8b7b rdf:first sg:person.01337142666.24
125 rdf:rest Ncee1172b9386416cbba3d1cf1d10601c
126 N28658fbb50bf4941b29c39c5d9c1e887 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name GPI-Linked Proteins
128 rdf:type schema:DefinedTerm
129 N2cc9376a4f7e4c05a7cc820569b7bf03 schema:name readcube_id
130 schema:value 898c2792192a4268bd048d164f6d31e2ea79c74109d8dc59808c94b64dead4c5
131 rdf:type schema:PropertyValue
132 N3666b65894af4f9caabbee9ec784bcca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name RNA, Messenger
134 rdf:type schema:DefinedTerm
135 N46b2e16905ad4da9a59e5233a18ca26e rdf:first sg:person.0663545617.31
136 rdf:rest N8de3d845f62748dbb3c70b0795bfdbcf
137 N49702c331a5242e7a0816325fdb1eb16 rdf:first sg:person.01173201114.72
138 rdf:rest N8a109b84fa1a45a388ae071bcbafd401
139 N4ebcfe29823b45619bce9a8ea5545d17 rdf:first sg:person.0674373366.09
140 rdf:rest Ne6d210b0cb784c9e8103f3dcc9c08a60
141 N521c31955c37474c99514da9a571d203 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Tumor Cells, Cultured
143 rdf:type schema:DefinedTerm
144 N603d5f3a8bfb4be38bd57368d578233f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Benzamides
146 rdf:type schema:DefinedTerm
147 N74446ab55adf45e0a825b766bcd3f1f5 schema:name nlm_unique_id
148 schema:value 0370635
149 rdf:type schema:PropertyValue
150 N7a7230e4e7a74f3eb1694fd70499dbb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Intercellular Signaling Peptides and Proteins
152 rdf:type schema:DefinedTerm
153 N7fa8e679ad34411191ba98383bbcc058 rdf:first sg:person.01142725140.44
154 rdf:rest N46b2e16905ad4da9a59e5233a18ca26e
155 N7fd7c3638a9b48b99d23156f7a495df3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Neoplasm Proteins
157 rdf:type schema:DefinedTerm
158 N837762f91c344cd4a8198e1bbe017603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cell Movement
160 rdf:type schema:DefinedTerm
161 N8a109b84fa1a45a388ae071bcbafd401 rdf:first sg:person.0714701423.61
162 rdf:rest N28440e31756848ce9df5e2f36d2d8b7b
163 N8b308313dcc14778b5847bb5daee95a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Quinazolines
165 rdf:type schema:DefinedTerm
166 N8de3d845f62748dbb3c70b0795bfdbcf rdf:first sg:person.01031130023.48
167 rdf:rest Nd500c03b843d41099751b55ab9c0ce20
168 N99c83779a8ef4d849985e842ff5ebcd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Neoplasm Invasiveness
170 rdf:type schema:DefinedTerm
171 Nb040967fc3684ed282fd3dc27de9e5f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Dioxoles
173 rdf:type schema:DefinedTerm
174 Nb3c1c981d9ff4c80bf47e887c786fd3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name src-Family Kinases
176 rdf:type schema:DefinedTerm
177 Nb52cda59067f400388202f85f0b1a8a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Activin Receptors, Type I
179 rdf:type schema:DefinedTerm
180 Nb6793c8b93624188bd6fda792790ee5a schema:issueNumber 7
181 rdf:type schema:PublicationIssue
182 Nb81f25cecc0340448e99e765e759da72 schema:name Laboratory of Pharmacogenomic, Centro di Ricerche Oncologiche di Mercogliano–CROM, Mercogliano (AV) 83013, Italy
183 rdf:type schema:Organization
184 Nba3ff33a945a45538f7f5a204ce8d487 rdf:first sg:person.01071726627.27
185 rdf:rest Nc33fe163f9db402aa8c2919831a409f7
186 Nba76988da78d45a4bf9fd2b19877d677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Reverse Transcriptase Polymerase Chain Reaction
188 rdf:type schema:DefinedTerm
189 Nc33fe163f9db402aa8c2919831a409f7 rdf:first sg:person.01362313740.14
190 rdf:rest N49702c331a5242e7a0816325fdb1eb16
191 Nc3c262ac8ec24a6e9a9352a1083ef1fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Flow Cytometry
193 rdf:type schema:DefinedTerm
194 Nc47b066863754f0a8892b372469439de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Benzodioxoles
196 rdf:type schema:DefinedTerm
197 Ncee1172b9386416cbba3d1cf1d10601c rdf:first sg:person.01254045424.97
198 rdf:rest N7fa8e679ad34411191ba98383bbcc058
199 Ncf93099ad8204455be728acf21cc9f1f schema:name Springer Nature - SN SciGraph project
200 rdf:type schema:Organization
201 Nd500c03b843d41099751b55ab9c0ce20 rdf:first sg:person.0712117565.12
202 rdf:rest N1bffde03773543c7a2522e7b580ede27
203 Nd912f3f20f184ed89afd4c0a17dc1046 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Smad Proteins
205 rdf:type schema:DefinedTerm
206 Nda7f640e573e4a92a509ecfe0b8c4d3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Cell Proliferation
208 rdf:type schema:DefinedTerm
209 Ndbe862b057c34dcd96994f12333c0476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Melanoma
211 rdf:type schema:DefinedTerm
212 Nde4e982748cb4bacaa8b95a7e788ff5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Skin Neoplasms
214 rdf:type schema:DefinedTerm
215 Ne6d210b0cb784c9e8103f3dcc9c08a60 rdf:first sg:person.01300115125.52
216 rdf:rest Nba3ff33a945a45538f7f5a204ce8d487
217 Nfdba0909e21941228670949edba29bef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Cell Adhesion
219 rdf:type schema:DefinedTerm
220 Nff98c41ab4214b298bc2cc5f652d1765 schema:name dimensions_id
221 schema:value pub.1028873662
222 rdf:type schema:PropertyValue
223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
224 schema:name Medical and Health Sciences
225 rdf:type schema:DefinedTerm
226 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
227 schema:name Oncology and Carcinogenesis
228 rdf:type schema:DefinedTerm
229 sg:grant.2478788 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2011.324
230 rdf:type schema:MonetaryGrant
231 sg:journal.1017082 schema:issn 0007-0920
232 1532-1827
233 schema:name British Journal of Cancer
234 rdf:type schema:Periodical
235 sg:person.01031130023.48 schema:affiliation https://www.grid.ac/institutes/grid.413808.6
236 schema:familyName Hendrix
237 schema:givenName M J C
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031130023.48
239 rdf:type schema:Person
240 sg:person.01071726627.27 schema:affiliation https://www.grid.ac/institutes/grid.413808.6
241 schema:familyName Strizzi
242 schema:givenName L
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071726627.27
244 rdf:type schema:Person
245 sg:person.01142725140.44 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
246 schema:familyName Botti
247 schema:givenName G
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142725140.44
249 rdf:type schema:Person
250 sg:person.01173201114.72 schema:affiliation N05640ec543d849f4ba20399c93121112
251 schema:familyName D'Antonio
252 schema:givenName A
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173201114.72
254 rdf:type schema:Person
255 sg:person.01254045424.97 schema:affiliation https://www.grid.ac/institutes/grid.475010.7
256 schema:familyName Hsu
257 schema:givenName M-Y
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254045424.97
259 rdf:type schema:Person
260 sg:person.01300115125.52 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
261 schema:familyName Lamura
262 schema:givenName L
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300115125.52
264 rdf:type schema:Person
265 sg:person.01337142666.24 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
266 schema:familyName Pirozzi
267 schema:givenName G
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337142666.24
269 rdf:type schema:Person
270 sg:person.01353442665.26 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
271 schema:familyName Normanno
272 schema:givenName N
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353442665.26
274 rdf:type schema:Person
275 sg:person.01362313740.14 schema:affiliation Nb81f25cecc0340448e99e765e759da72
276 schema:familyName Roma
277 schema:givenName C
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362313740.14
279 rdf:type schema:Person
280 sg:person.0663545617.31 schema:affiliation https://www.grid.ac/institutes/grid.476012.6
281 schema:familyName Mari
282 schema:givenName E
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663545617.31
284 rdf:type schema:Person
285 sg:person.0674373366.09 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
286 schema:familyName De Luca
287 schema:givenName A
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674373366.09
289 rdf:type schema:Person
290 sg:person.0712117565.12 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
291 schema:familyName Salomon
292 schema:givenName D S
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712117565.12
294 rdf:type schema:Person
295 sg:person.0714701423.61 schema:affiliation https://www.grid.ac/institutes/grid.413808.6
296 schema:familyName Margaryan
297 schema:givenName N
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714701423.61
299 rdf:type schema:Person
300 sg:pub.10.1038/nature05661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021487923
301 https://doi.org/10.1038/nature05661
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nm1448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021581886
304 https://doi.org/10.1038/nm1448
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/sj.onc.1203979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051921823
307 https://doi.org/10.1038/sj.onc.1203979
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/sj.onc.1205859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014860210
310 https://doi.org/10.1038/sj.onc.1205859
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/sj.onc.1208417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031787297
313 https://doi.org/10.1038/sj.onc.1208417
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/sj.onc.1208918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049663453
316 https://doi.org/10.1038/sj.onc.1208918
317 rdf:type schema:CreativeWork
318 sg:pub.10.1186/1478-811x-7-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034223270
319 https://doi.org/10.1186/1478-811x-7-10
320 rdf:type schema:CreativeWork
321 sg:pub.10.1186/1479-5876-6-53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006414800
322 https://doi.org/10.1186/1479-5876-6-53
323 rdf:type schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1075255974 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1076893883 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1077645852 schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1078189938 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1078824787 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1082467183 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1082747058 schema:CreativeWork
331 https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<589::aid-ijc17>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1041394981
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1002/jcp.10375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028981370
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1002/jcp.20588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048424447
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1002/path.2083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003862661
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.exer.2007.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015179936
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s0002-9440(10)63000-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012111147
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s0070-2153(05)67003-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008400474
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s1097-2765(01)00249-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430116
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1038/emboj.2008.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012263251
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1056/nejmra052166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037124002
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1073/pnas.0800467105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033904137
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1091/mbc.e05-10-0927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022708759
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1093/intimm/12.6.787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052371082
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/jnci/88.7.419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036926193
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1097/cmr.0b013e328304974c schema:sameAs https://app.dimensions.ai/details/publication/pub.1037140481
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1101/gad.201801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031884983
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1126/scisignal.1165027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062681778
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1128/mcb.01168-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001777226
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1128/mcb.22.8.2586-2597.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038693082
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1158/0008-5472.can-03-3888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050525398
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1158/1078-0432.ccr-05-1940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041811648
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1158/1541-7786.mcr-08-0169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049231349
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1172/jci17788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024373547
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1517/14728222.11.1.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041884182
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1586/17469872.4.1.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012348396
380 rdf:type schema:CreativeWork
381 https://doi.org/10.2741/normano schema:sameAs https://app.dimensions.ai/details/publication/pub.1070918293
382 rdf:type schema:CreativeWork
383 https://doi.org/10.3892/ijo.21.5.941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071514823
384 rdf:type schema:CreativeWork
385 https://doi.org/10.4161/cc.7.13.6236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299538
386 rdf:type schema:CreativeWork
387 https://www.grid.ac/institutes/grid.413808.6 schema:alternateName Lurie Children's Hospital
388 schema:name Children's Memorial Research Center, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614-4314, USA
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
391 schema:name Cell Biology and Biotherapy Unit, Research Department, INT-Fondazione Pascale, Naples 80131, Italy
392 Pathology Unit, INT-Fondazione Pascale, Naples 80131, Italy
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.475010.7 schema:alternateName Boston University School of Medicine
395 schema:name Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.476012.6 schema:alternateName AstraZeneca (Italy)
398 schema:name AstraZeneca, Basiglio (MI) 20080, Italy
399 rdf:type schema:Organization
400 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
401 schema:name Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
402 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...