Expression of a truncated form of hHb1 hair keratin in human breast carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-12

AUTHORS

C H Régnier, A Boulay, P H Asch, C Wendling, M P Chenard, C Tomasetto, M C Rio

ABSTRACT

Human hHb1 belongs to the type II hard keratin family and is physiologically expressed in hair shafts. In the present study, using specific 3' and 5' probes for hHb1, we established that breast carcinomas ectopically express a hHb1 5'-truncated mRNA, and that this transcript is restricted to malignant epithelial cells. Furthermore, an in vitro study indicated that it could be translated. We concluded that, in breast carcinomas, expression of truncated hHb1 is related to epithelial cell transformation. Because the hHb1 gene maps to 12q11-q13, a chromosome region known to present several breakpoints in solid tumours, we propose that the hHb1 gene might represent a target for such alterations. More... »

PAGES

1640

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1998.736

DOI

http://dx.doi.org/10.1038/bjc.1998.736

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051359583

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9862577


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