Moderate amplifications of the c-myc gene correlate with molecular and clinicopathological parameters in colorectal cancer. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-06

AUTHORS

L. Masramon, R. Arribas, S. Tórtola, M. Perucho, M. A. Peinado

ABSTRACT

C-myc gene activation is a common event in multiple types of neoplasia and has been associated with different cellular processes relevant to the malignant transformation of cancer cells. C-myc gene amplification has been analysed in colorectal carcinomas by means of an innovative DNA fingerprinting method based on the arbitrarily primed PCR. This method requires a low amount of DNA, uses multiple internal controls and appears sensitive and reproducible. Clinicopathological and molecular correlates have been investigated in a series of 70 colorectal carcinomas. The incidence of c-myc amplification was 26%, ranging from two- to fivefold increase in copy number. C-myc amplification occurrence was more frequent in more advanced stages of tumour invasion (P < 0.001) and was associated with mutations in the p53 tumour-suppressor gene (P = 0.048). The presence of c-myc amplification was indicative of a shorter disease-free survival period but, because of its strong association with Dukes' stage, its prognostic value is questionable. More... »

PAGES

2349-2356

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1998.390

DOI

http://dx.doi.org/10.1038/bjc.1998.390

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009985802

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9649157


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