Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-05

AUTHORS

R A McClelland, D L Manning, J M Gee, P Willsher, J F Robertson, I O Ellis, R W Blamey, R I Nicholson

ABSTRACT

Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy. More... »

PAGES

bjc1998271

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1998.271

DOI

http://dx.doi.org/10.1038/bjc.1998.271

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007254632

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9635843


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