Reversion of multidrug resistance with polyalkylcyanoacrylate nanoparticles: towards a mechanism of action View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-07

AUTHORS

A C de Verdière, C Dubernet, F Némati, E Soma, M Appel, J Ferté, S Bernard, F Puisieux, P Couvreur

ABSTRACT

Polyalkylcyanoacrylate (PACA) nanoparticles loaded with doxorubicin allowed multidrug resistance to be overcome in vitro. However, increased cytotoxicity is not always correlated with an increased level of intracellular drug. Although we have previously shown that PACA nanoparticles are not endocytosed by tumour cells, we report here that a direct interaction between nanoparticles and cells is a necessary requirement for overcoming resistance. In addition, the results showed that the degradation products of PACA (mainly polycyanoacrylic acid) in the presence of doxorubicin are able to increase both accumulation and cytotoxicity, thus suggesting the formation of a doxorubicin-polycyanoacrylic acid ion pair. It is therefore concluded that resistance is overcome as a result of both the adsorption of nanoparticles to the cell surface and increased doxorubicin diffusion by the accumulation of an ion pair at the plasma membrane. More... »

PAGES

bjc1997362

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1997.362

DOI

http://dx.doi.org/10.1038/bjc.1997.362

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045801927

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9231919


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