Relationship between TA01 and TA02 polypeptides associated with lung adenocarcinoma and histocytological features View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-04

AUTHORS

T Hirano, K Fujioka, B Franzèn, K Okuzawa, K Uryu, H Shibanuma, K Numata, C Konaka, Y Ebihara, M Takahashi, H Kato, G Auer

ABSTRACT

TA01 (molecular weight 35.0 kDa, isoelectric point 5.45) and TA02 (molecular weight 35.0 kDa, isoelectric point 5.29) polypeptides were detected using two-dimensional polyacrylamide gel electrophoresis (2-DE). A previous study has shown that these polypeptides are distributed in primary adenocarcinomas and some large-cell carcinomas of the lung. However, various expression levels of TA01 and TA02 polypeptides were demonstrated in adenocarcinoma, while large-cell carcinoma expressed low levels. To evaluate the relationship between the expression of TA01 and TA02 polypeptides and the histocytological features of primary adenocarcinoma of the lung, these two polypeptides were analysed by 2-DE combined with a non-enzymatic sample preparation technique, and their expression levels were compared with the histocytological features of primary lung adenocarcinoma. Out of 57 primary lung adenocarcinoma cases, 46 cases (80.7%) and 52 cases (91.2%) expressed TA01 and TA02 polypeptides respectively. Furthermore, the expression levels of TA01 and TA02 polypeptides correlated with the degree of cellular atypia, structural atypia and histocytological differentiation of primary lung adenocarcinoma. On the other hand, these two polypeptides were not detected in adenocarcinoma of the lung, metastatic from the colon and mammary glands. High expression of TA01 and TA02 polypeptides reflected the differentiation of primary adenocarcinoma in the lung. These two polypeptides are valuable in determining the histocytological differentiation of primary lung adenocarcinoma as well as in distinguishing between primary and metastatic adenocarcinoma of the lung. More... »

PAGES

978

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1997.169

DOI

http://dx.doi.org/10.1038/bjc.1997.169

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043816286

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9083332


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Gel, Two-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoelectric Point", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokyo Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410793.8", 
          "name": [
            "Department of Surgery, Tokyo Medical College, Shinjuku-ku, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirano", 
        "givenName": "T", 
        "id": "sg:person.0664140561.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664140561.45"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fujioka", 
        "givenName": "K", 
        "id": "sg:person.01141202273.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141202273.15"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Franz\u00e8n", 
        "givenName": "B", 
        "id": "sg:person.01255225441.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Okuzawa", 
        "givenName": "K", 
        "id": "sg:person.01130473444.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130473444.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Uryu", 
        "givenName": "K", 
        "id": "sg:person.01223030154.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223030154.53"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Shibanuma", 
        "givenName": "H", 
        "id": "sg:person.01371657273.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371657273.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Numata", 
        "givenName": "K", 
        "type": "Person"
      }, 
      {
        "familyName": "Konaka", 
        "givenName": "C", 
        "id": "sg:person.015450706207.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015450706207.19"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ebihara", 
        "givenName": "Y", 
        "id": "sg:person.011716303242.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011716303242.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Takahashi", 
        "givenName": "M", 
        "id": "sg:person.01207060455.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207060455.61"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kato", 
        "givenName": "H", 
        "id": "sg:person.010317272332.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010317272332.81"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Auer", 
        "givenName": "G", 
        "id": "sg:person.01314041754.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1996.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000048663", 
          "https://doi.org/10.1038/bjc.1996.163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000048663", 
          "https://doi.org/10.1038/bjc.1996.163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(86)80133-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001028046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)91748-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003021022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)91748-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003021022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/ajrcmb/3.5.491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006556527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501301198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010772626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501301198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010772626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.93.3.565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012082817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/97.2.233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017265693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020756523", 
          "https://doi.org/10.1038/bjc.1995.422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020756523", 
          "https://doi.org/10.1038/bjc.1995.422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19821215)50:12<2894::aid-cncr2820501232>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021527207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197908)44:2<685::aid-cncr2820440241>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023278813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008469-199504000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024782157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008469-199504000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024782157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(81)90783-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026906217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028789496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028789496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19880901)62:5<973::aid-cncr2820620521>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033057157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-8049(93)90387-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033405157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034716677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034716677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90379-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036794378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(81)90171-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043512055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/36.1.3275712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044787926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/36.1.3275712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044787926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048462261", 
          "https://doi.org/10.1038/bjc.1995.277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048462261", 
          "https://doi.org/10.1038/bjc.1995.277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049052655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049052655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910520603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053572506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076949006", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078652381", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078723046", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078996607", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079038759", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079418249", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079503823", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081651811", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082560990", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-04", 
    "datePublishedReg": "1997-04-01", 
    "description": "TA01 (molecular weight 35.0 kDa, isoelectric point 5.45) and TA02 (molecular weight 35.0 kDa, isoelectric point 5.29) polypeptides were detected using two-dimensional polyacrylamide gel electrophoresis (2-DE). A previous study has shown that these polypeptides are distributed in primary adenocarcinomas and some large-cell carcinomas of the lung. However, various expression levels of TA01 and TA02 polypeptides were demonstrated in adenocarcinoma, while large-cell carcinoma expressed low levels. To evaluate the relationship between the expression of TA01 and TA02 polypeptides and the histocytological features of primary adenocarcinoma of the lung, these two polypeptides were analysed by 2-DE combined with a non-enzymatic sample preparation technique, and their expression levels were compared with the histocytological features of primary lung adenocarcinoma. Out of 57 primary lung adenocarcinoma cases, 46 cases (80.7%) and 52 cases (91.2%) expressed TA01 and TA02 polypeptides respectively. Furthermore, the expression levels of TA01 and TA02 polypeptides correlated with the degree of cellular atypia, structural atypia and histocytological differentiation of primary lung adenocarcinoma. On the other hand, these two polypeptides were not detected in adenocarcinoma of the lung, metastatic from the colon and mammary glands. High expression of TA01 and TA02 polypeptides reflected the differentiation of primary adenocarcinoma in the lung. These two polypeptides are valuable in determining the histocytological differentiation of primary lung adenocarcinoma as well as in distinguishing between primary and metastatic adenocarcinoma of the lung.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1997.169", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "75"
      }
    ], 
    "name": "Relationship between TA01 and TA02 polypeptides associated with lung adenocarcinoma and histocytological features", 
    "pagination": "978", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d0b6de5873d23895594001d82bd1bec9f8faab5c90cbb49c629e999431e524f9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9083332"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1997.169"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043816286"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1997.169", 
      "https://app.dimensions.ai/details/publication/pub.1043816286"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53978_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc1997169"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1997.169'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1997.169'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1997.169'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1997.169'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      69 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1997.169 schema:about N0def67b777a2403ca7e2539f99c0062c
2 N224255f3cf534d079a741a6eff1c77f9
3 N4132866afe4e4774a6d86061ce97a865
4 N4ea10b196f604ca2af21520354e90258
5 N7307b4e7b89e44b7b1ba49bc76982bcf
6 Na5fbb99a60c643479df76b6390ededd1
7 Na99306e5d580422eb1567ab4a22a8ad5
8 Ne556e23b9b544953974c35b86b942af8
9 Nf54548c15e4b4f4fba8f527c8978508d
10 anzsrc-for:11
11 anzsrc-for:1102
12 schema:author N8a2f00c4aeb0455abb969c8a233c2800
13 schema:citation sg:pub.10.1038/bjc.1995.277
14 sg:pub.10.1038/bjc.1995.422
15 sg:pub.10.1038/bjc.1996.163
16 https://app.dimensions.ai/details/publication/pub.1076949006
17 https://app.dimensions.ai/details/publication/pub.1078652381
18 https://app.dimensions.ai/details/publication/pub.1078723046
19 https://app.dimensions.ai/details/publication/pub.1078996607
20 https://app.dimensions.ai/details/publication/pub.1079038759
21 https://app.dimensions.ai/details/publication/pub.1079418249
22 https://app.dimensions.ai/details/publication/pub.1079503823
23 https://app.dimensions.ai/details/publication/pub.1081651811
24 https://app.dimensions.ai/details/publication/pub.1082560990
25 https://doi.org/10.1002/1097-0142(197908)44:2<685::aid-cncr2820440241>3.0.co;2-1
26 https://doi.org/10.1002/1097-0142(19821215)50:12<2894::aid-cncr2820501232>3.0.co;2-g
27 https://doi.org/10.1002/1097-0142(19880901)62:5<973::aid-cncr2820620521>3.0.co;2-o
28 https://doi.org/10.1002/elps.11501301198
29 https://doi.org/10.1002/elps.11501401167
30 https://doi.org/10.1002/elps.1150150157
31 https://doi.org/10.1002/elps.1150150171
32 https://doi.org/10.1002/ijc.2910520603
33 https://doi.org/10.1016/0003-2697(81)90783-1
34 https://doi.org/10.1016/0014-4827(81)90171-3
35 https://doi.org/10.1016/0277-5379(91)90379-r
36 https://doi.org/10.1016/0959-8049(93)90387-u
37 https://doi.org/10.1016/s0046-8177(86)80133-2
38 https://doi.org/10.1016/s0140-6736(82)91748-2
39 https://doi.org/10.1093/ajcp/97.2.233
40 https://doi.org/10.1097/00008469-199504000-00002
41 https://doi.org/10.1165/ajrcmb/3.5.491
42 https://doi.org/10.1177/36.1.3275712
43 https://doi.org/10.1378/chest.93.3.565
44 schema:datePublished 1997-04
45 schema:datePublishedReg 1997-04-01
46 schema:description TA01 (molecular weight 35.0 kDa, isoelectric point 5.45) and TA02 (molecular weight 35.0 kDa, isoelectric point 5.29) polypeptides were detected using two-dimensional polyacrylamide gel electrophoresis (2-DE). A previous study has shown that these polypeptides are distributed in primary adenocarcinomas and some large-cell carcinomas of the lung. However, various expression levels of TA01 and TA02 polypeptides were demonstrated in adenocarcinoma, while large-cell carcinoma expressed low levels. To evaluate the relationship between the expression of TA01 and TA02 polypeptides and the histocytological features of primary adenocarcinoma of the lung, these two polypeptides were analysed by 2-DE combined with a non-enzymatic sample preparation technique, and their expression levels were compared with the histocytological features of primary lung adenocarcinoma. Out of 57 primary lung adenocarcinoma cases, 46 cases (80.7%) and 52 cases (91.2%) expressed TA01 and TA02 polypeptides respectively. Furthermore, the expression levels of TA01 and TA02 polypeptides correlated with the degree of cellular atypia, structural atypia and histocytological differentiation of primary lung adenocarcinoma. On the other hand, these two polypeptides were not detected in adenocarcinoma of the lung, metastatic from the colon and mammary glands. High expression of TA01 and TA02 polypeptides reflected the differentiation of primary adenocarcinoma in the lung. These two polypeptides are valuable in determining the histocytological differentiation of primary lung adenocarcinoma as well as in distinguishing between primary and metastatic adenocarcinoma of the lung.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N553dfcc2a3a148738483e673e7851489
51 Nfbd6d12ffb27495faabf7fe66b89dd23
52 sg:journal.1017082
53 schema:name Relationship between TA01 and TA02 polypeptides associated with lung adenocarcinoma and histocytological features
54 schema:pagination 978
55 schema:productId N6eb2b116f7c7417185d050fa9dd7286a
56 N712fa253c7dd4b1fbb7e815d5ee32ca1
57 N800f9359bf1d4f21891f61ef87de2fe5
58 N8f367d251261435087fc92b7e6642435
59 Nbe69bcd51ac043038b6ab7ea2d388fd5
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043816286
61 https://doi.org/10.1038/bjc.1997.169
62 schema:sdDatePublished 2019-04-11T12:11
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher Naaf8543d4cc64a8fafa1768b8c29e649
65 schema:url https://www.nature.com/articles/bjc1997169
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N0def67b777a2403ca7e2539f99c0062c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Electrophoresis, Gel, Two-Dimensional
71 rdf:type schema:DefinedTerm
72 N1479b02009624b769269a7a3b308c45f rdf:first sg:person.015450706207.19
73 rdf:rest N96131afcedaf47219852442e8404f049
74 N224255f3cf534d079a741a6eff1c77f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Humans
76 rdf:type schema:DefinedTerm
77 N2ecc1f2ac685424d9c1831973fc3ba98 rdf:first sg:person.010317272332.81
78 rdf:rest N3461a6d50fd9442fa34f55ea204b139f
79 N3461a6d50fd9442fa34f55ea204b139f rdf:first sg:person.01314041754.28
80 rdf:rest rdf:nil
81 N410b635b7bc6463193404687eb5c2104 schema:familyName Numata
82 schema:givenName K
83 rdf:type schema:Person
84 N4132866afe4e4774a6d86061ce97a865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Neoplasm Proteins
86 rdf:type schema:DefinedTerm
87 N434783ad1dba45caaf8441109d9ce7d8 rdf:first sg:person.01255225441.66
88 rdf:rest N8d210568a4084778ad1ada4f35939fff
89 N4ea10b196f604ca2af21520354e90258 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Biomarkers, Tumor
91 rdf:type schema:DefinedTerm
92 N553dfcc2a3a148738483e673e7851489 schema:issueNumber 7
93 rdf:type schema:PublicationIssue
94 N5f23a777578e4e58a0f8507fa409f942 rdf:first sg:person.01223030154.53
95 rdf:rest N62575c89c059403982f3390413de356a
96 N62575c89c059403982f3390413de356a rdf:first sg:person.01371657273.29
97 rdf:rest N829d085ff81d4632a16fac5ecb40a6d3
98 N6eb2b116f7c7417185d050fa9dd7286a schema:name pubmed_id
99 schema:value 9083332
100 rdf:type schema:PropertyValue
101 N712fa253c7dd4b1fbb7e815d5ee32ca1 schema:name dimensions_id
102 schema:value pub.1043816286
103 rdf:type schema:PropertyValue
104 N7307b4e7b89e44b7b1ba49bc76982bcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Molecular Weight
106 rdf:type schema:DefinedTerm
107 N800f9359bf1d4f21891f61ef87de2fe5 schema:name nlm_unique_id
108 schema:value 0370635
109 rdf:type schema:PropertyValue
110 N829d085ff81d4632a16fac5ecb40a6d3 rdf:first N410b635b7bc6463193404687eb5c2104
111 rdf:rest N1479b02009624b769269a7a3b308c45f
112 N8a2f00c4aeb0455abb969c8a233c2800 rdf:first sg:person.0664140561.45
113 rdf:rest Nd5e720a899614fe1996c98f6548921bb
114 N8d210568a4084778ad1ada4f35939fff rdf:first sg:person.01130473444.66
115 rdf:rest N5f23a777578e4e58a0f8507fa409f942
116 N8f367d251261435087fc92b7e6642435 schema:name doi
117 schema:value 10.1038/bjc.1997.169
118 rdf:type schema:PropertyValue
119 N96131afcedaf47219852442e8404f049 rdf:first sg:person.011716303242.09
120 rdf:rest Nab9c69b6025e4618a2006591244f3abf
121 Na5fbb99a60c643479df76b6390ededd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cell Differentiation
123 rdf:type schema:DefinedTerm
124 Na99306e5d580422eb1567ab4a22a8ad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Adenocarcinoma
126 rdf:type schema:DefinedTerm
127 Naaf8543d4cc64a8fafa1768b8c29e649 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 Nab9c69b6025e4618a2006591244f3abf rdf:first sg:person.01207060455.61
130 rdf:rest N2ecc1f2ac685424d9c1831973fc3ba98
131 Nbe69bcd51ac043038b6ab7ea2d388fd5 schema:name readcube_id
132 schema:value d0b6de5873d23895594001d82bd1bec9f8faab5c90cbb49c629e999431e524f9
133 rdf:type schema:PropertyValue
134 Nd5e720a899614fe1996c98f6548921bb rdf:first sg:person.01141202273.15
135 rdf:rest N434783ad1dba45caaf8441109d9ce7d8
136 Ne556e23b9b544953974c35b86b942af8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Lung Neoplasms
138 rdf:type schema:DefinedTerm
139 Nf54548c15e4b4f4fba8f527c8978508d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Isoelectric Point
141 rdf:type schema:DefinedTerm
142 Nfbd6d12ffb27495faabf7fe66b89dd23 schema:volumeNumber 75
143 rdf:type schema:PublicationVolume
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
148 schema:name Cardiorespiratory Medicine and Haematology
149 rdf:type schema:DefinedTerm
150 sg:journal.1017082 schema:issn 0007-0920
151 1532-1827
152 schema:name British Journal of Cancer
153 rdf:type schema:Periodical
154 sg:person.010317272332.81 schema:familyName Kato
155 schema:givenName H
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010317272332.81
157 rdf:type schema:Person
158 sg:person.01130473444.66 schema:familyName Okuzawa
159 schema:givenName K
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130473444.66
161 rdf:type schema:Person
162 sg:person.01141202273.15 schema:familyName Fujioka
163 schema:givenName K
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141202273.15
165 rdf:type schema:Person
166 sg:person.011716303242.09 schema:familyName Ebihara
167 schema:givenName Y
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011716303242.09
169 rdf:type schema:Person
170 sg:person.01207060455.61 schema:familyName Takahashi
171 schema:givenName M
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207060455.61
173 rdf:type schema:Person
174 sg:person.01223030154.53 schema:familyName Uryu
175 schema:givenName K
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223030154.53
177 rdf:type schema:Person
178 sg:person.01255225441.66 schema:familyName Franzèn
179 schema:givenName B
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66
181 rdf:type schema:Person
182 sg:person.01314041754.28 schema:familyName Auer
183 schema:givenName G
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28
185 rdf:type schema:Person
186 sg:person.01371657273.29 schema:familyName Shibanuma
187 schema:givenName H
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371657273.29
189 rdf:type schema:Person
190 sg:person.015450706207.19 schema:familyName Konaka
191 schema:givenName C
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015450706207.19
193 rdf:type schema:Person
194 sg:person.0664140561.45 schema:affiliation https://www.grid.ac/institutes/grid.410793.8
195 schema:familyName Hirano
196 schema:givenName T
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664140561.45
198 rdf:type schema:Person
199 sg:pub.10.1038/bjc.1995.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048462261
200 https://doi.org/10.1038/bjc.1995.277
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/bjc.1995.422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020756523
203 https://doi.org/10.1038/bjc.1995.422
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/bjc.1996.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000048663
206 https://doi.org/10.1038/bjc.1996.163
207 rdf:type schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1076949006 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1078652381 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1078723046 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1078996607 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1079038759 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1079418249 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1079503823 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1081651811 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1082560990 schema:CreativeWork
217 https://doi.org/10.1002/1097-0142(197908)44:2<685::aid-cncr2820440241>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023278813
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/1097-0142(19821215)50:12<2894::aid-cncr2820501232>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1021527207
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/1097-0142(19880901)62:5<973::aid-cncr2820620521>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1033057157
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/elps.11501301198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010772626
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1002/elps.11501401167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049052655
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/elps.1150150157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028789496
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/elps.1150150171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034716677
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/ijc.2910520603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053572506
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0003-2697(81)90783-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026906217
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0014-4827(81)90171-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043512055
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0277-5379(91)90379-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1036794378
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0959-8049(93)90387-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1033405157
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0046-8177(86)80133-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001028046
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0140-6736(82)91748-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003021022
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/ajcp/97.2.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017265693
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1097/00008469-199504000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024782157
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1165/ajrcmb/3.5.491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006556527
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1177/36.1.3275712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044787926
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1378/chest.93.3.565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012082817
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.410793.8 schema:alternateName Tokyo Medical University
256 schema:name Department of Surgery, Tokyo Medical College, Shinjuku-ku, Japan.
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...