Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-11

AUTHORS

B Franzén, S Linder, A A Alaiya, E Eriksson, K Uruy, T Hirano, K Okuzawa, G Auer

ABSTRACT

Malignant progression of tumour cells is caused by the accumulation of genetic defects, which when combined will generate a large phenotypic diversity. Simultaneous quantitation of a large number of gene products in tumour cells is desirable, but difficult to achieve. We have here quantitated the levels of a number of abundant polypeptides in human breast carcinoma cells using two-dimensional gel electrophoresis (2-DE; PDQUEST). For this purpose, tumour cells were prepared from the tissue of 17 breast carcinomas. Fibroadenoma tissue was used as reference for benign cells. An increase of the spot density of the PCNA polypeptide was observed in rapidly proliferating tumour cells, confirming the validity of the procedures used. In the set of 24 polypeptide spots with known identity, decreases in cytokeratin and tropomyosin levels were observed. The levels of all cytokeratin forms resolved (CK7, CK8, CK15 and CK18) were significantly lower in carcinomas than in fibroadenomas. The levels of tropomyosin 2 and 3 were lower in carcinomas than in fibroadenomas. In contrast, the levels of some members of the stress protein family (pHSP60, HSP90 and calreticulin) were higher in carcinomas. Furthermore, changes in the expression of lactate dehydrogenase and GT-pi, but not in nm23, were observed. We conclude that simultaneous analysis of multiple polypeptides in human carcinomas can be achieved by 2-DE and may be useful in prognostic studies, and that malignant progression of breast carcinomas results in the decreased expression of cytokeratin polypeptides. This phenomenon must be considered in studies where cytokeratins are used as markers to identify the epithelial cell compartment in breast carcinomas. More... »

PAGES

bjc1996600

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1996.600

DOI

http://dx.doi.org/10.1038/bjc.1996.600

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013907198

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8932346


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Gel, Two-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroadenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione Transferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monomeric GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NM23 Nucleoside Diphosphate Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleoside-Diphosphate Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Unit of Cell and Molecular Analysis, Karolinska Institute and Hospital, Stockholm, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franz\u00e9n", 
        "givenName": "B", 
        "id": "sg:person.01255225441.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Linder", 
        "givenName": "S", 
        "id": "sg:person.01050565740.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Alaiya", 
        "givenName": "A A", 
        "id": "sg:person.01176606644.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176606644.55"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Eriksson", 
        "givenName": "E", 
        "id": "sg:person.01360376772.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360376772.70"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Uruy", 
        "givenName": "K", 
        "type": "Person"
      }, 
      {
        "familyName": "Hirano", 
        "givenName": "T", 
        "id": "sg:person.0664140561.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664140561.45"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Okuzawa", 
        "givenName": "K", 
        "id": "sg:person.01130473444.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130473444.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Auer", 
        "givenName": "G", 
        "id": "sg:person.01314041754.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1994.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001764806", 
          "https://doi.org/10.1038/bjc.1994.99"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001764806", 
          "https://doi.org/10.1038/bjc.1994.99"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.48.1.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002361457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00662142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004523382", 
          "https://doi.org/10.1007/bf00662142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00662142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004523382", 
          "https://doi.org/10.1007/bf00662142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005044804", 
          "https://doi.org/10.1038/bjc.1996.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005044804", 
          "https://doi.org/10.1038/bjc.1996.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008369910", 
          "https://doi.org/10.1038/bjc.1994.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008369910", 
          "https://doi.org/10.1038/bjc.1994.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501601355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016783346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501601355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016783346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(79)90529-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019593422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10409239309086794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024749967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(80)90216-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026167304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028789496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028789496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.6.2319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031316489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(84)90467-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032604575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-164720-9.50006-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035520994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049052655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049052655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.17.1419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075997376", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077352140", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077360823", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077673765", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079038759", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080104193", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080529965", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081645831", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082406366", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082532987", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-11", 
    "datePublishedReg": "1996-11-01", 
    "description": "Malignant progression of tumour cells is caused by the accumulation of genetic defects, which when combined will generate a large phenotypic diversity. Simultaneous quantitation of a large number of gene products in tumour cells is desirable, but difficult to achieve. We have here quantitated the levels of a number of abundant polypeptides in human breast carcinoma cells using two-dimensional gel electrophoresis (2-DE; PDQUEST). For this purpose, tumour cells were prepared from the tissue of 17 breast carcinomas. Fibroadenoma tissue was used as reference for benign cells. An increase of the spot density of the PCNA polypeptide was observed in rapidly proliferating tumour cells, confirming the validity of the procedures used. In the set of 24 polypeptide spots with known identity, decreases in cytokeratin and tropomyosin levels were observed. The levels of all cytokeratin forms resolved (CK7, CK8, CK15 and CK18) were significantly lower in carcinomas than in fibroadenomas. The levels of tropomyosin 2 and 3 were lower in carcinomas than in fibroadenomas. In contrast, the levels of some members of the stress protein family (pHSP60, HSP90 and calreticulin) were higher in carcinomas. Furthermore, changes in the expression of lactate dehydrogenase and GT-pi, but not in nm23, were observed. We conclude that simultaneous analysis of multiple polypeptides in human carcinomas can be achieved by 2-DE and may be useful in prognostic studies, and that malignant progression of breast carcinomas results in the decreased expression of cytokeratin polypeptides. This phenomenon must be considered in studies where cytokeratins are used as markers to identify the epithelial cell compartment in breast carcinomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1996.600", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "74"
      }
    ], 
    "name": "Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins", 
    "pagination": "bjc1996600", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4240017f3df3562c4cd033f786aad65831f6e3d4472aaa2fc49a9e2a02f9c117"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8932346"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1996.600"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013907198"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1996.600", 
      "https://app.dimensions.ai/details/publication/pub.1013907198"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29181_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/bjc1996600"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      21 PREDICATES      71 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1996.600 schema:about N078e2ae92803452784a52c6d563a69f3
2 N0e32d509e44646bc984d4d96f861ad65
3 N1cf683efd68b424c902f66a40a6976cb
4 N35a7c093d4a248ac8bbdcd030da8bd95
5 N3852b23cb11c48d299b98e55b3601080
6 N4779588ecaa24f73bf52fa42a3c1264d
7 N47e0443e3a9e436eb0776dc5ae2c20ae
8 N5813c1a7c2b54f46ad39dac0a0afc33e
9 N750d4155e6f74eeaa20bc55533226e93
10 N9e59363b09224d6ebe277ea4eea93f6c
11 Na709a577a1954d0f9fb1b4e80839c179
12 Nd03d43b487e64178be7b1ada33a91e98
13 Nd9343f2c7447432295f7c87b0cb553e8
14 Nd9afe2494e4c4df2a6e00c61480cd4f9
15 Nd9b3b1c06b64482cb8c26ba516959f65
16 Ndcb55b5741624512b22053bd18ffd5e6
17 Nf393e7140adf4e0b957bf67126300b9f
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Nb313373a93c747e19fd825d79c568a50
21 schema:citation sg:pub.10.1007/bf00662142
22 sg:pub.10.1038/bjc.1994.103
23 sg:pub.10.1038/bjc.1994.99
24 sg:pub.10.1038/bjc.1996.162
25 https://app.dimensions.ai/details/publication/pub.1075997376
26 https://app.dimensions.ai/details/publication/pub.1077352140
27 https://app.dimensions.ai/details/publication/pub.1077360823
28 https://app.dimensions.ai/details/publication/pub.1077673765
29 https://app.dimensions.ai/details/publication/pub.1079038759
30 https://app.dimensions.ai/details/publication/pub.1080104193
31 https://app.dimensions.ai/details/publication/pub.1080529965
32 https://app.dimensions.ai/details/publication/pub.1081645831
33 https://app.dimensions.ai/details/publication/pub.1082406366
34 https://app.dimensions.ai/details/publication/pub.1082532987
35 https://doi.org/10.1002/elps.11501401167
36 https://doi.org/10.1002/elps.1150150157
37 https://doi.org/10.1002/elps.11501601355
38 https://doi.org/10.1016/0014-4827(79)90529-9
39 https://doi.org/10.1016/0014-4827(84)90467-1
40 https://doi.org/10.1016/0022-2836(80)90216-8
41 https://doi.org/10.1016/b978-0-12-164720-9.50006-4
42 https://doi.org/10.1073/pnas.87.6.2319
43 https://doi.org/10.1093/jnci/85.17.1419
44 https://doi.org/10.1136/jcp.48.1.26
45 https://doi.org/10.3109/10409239309086794
46 schema:datePublished 1996-11
47 schema:datePublishedReg 1996-11-01
48 schema:description Malignant progression of tumour cells is caused by the accumulation of genetic defects, which when combined will generate a large phenotypic diversity. Simultaneous quantitation of a large number of gene products in tumour cells is desirable, but difficult to achieve. We have here quantitated the levels of a number of abundant polypeptides in human breast carcinoma cells using two-dimensional gel electrophoresis (2-DE; PDQUEST). For this purpose, tumour cells were prepared from the tissue of 17 breast carcinomas. Fibroadenoma tissue was used as reference for benign cells. An increase of the spot density of the PCNA polypeptide was observed in rapidly proliferating tumour cells, confirming the validity of the procedures used. In the set of 24 polypeptide spots with known identity, decreases in cytokeratin and tropomyosin levels were observed. The levels of all cytokeratin forms resolved (CK7, CK8, CK15 and CK18) were significantly lower in carcinomas than in fibroadenomas. The levels of tropomyosin 2 and 3 were lower in carcinomas than in fibroadenomas. In contrast, the levels of some members of the stress protein family (pHSP60, HSP90 and calreticulin) were higher in carcinomas. Furthermore, changes in the expression of lactate dehydrogenase and GT-pi, but not in nm23, were observed. We conclude that simultaneous analysis of multiple polypeptides in human carcinomas can be achieved by 2-DE and may be useful in prognostic studies, and that malignant progression of breast carcinomas results in the decreased expression of cytokeratin polypeptides. This phenomenon must be considered in studies where cytokeratins are used as markers to identify the epithelial cell compartment in breast carcinomas.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N78d92458d1df417c94bb1237ae4a05a5
53 Nca3f484f47eb4240b85908985d0c1b6e
54 sg:journal.1017082
55 schema:name Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins
56 schema:pagination bjc1996600
57 schema:productId N5c2913d43faa4068a33dc7d5c7818ae3
58 N6a1cc203c8b04bf8a7eda4ea12f80aa3
59 N9da4dff773b04425bf64efa8f3c3aefe
60 Nb096c38ba45645df823d857f2de2647c
61 Ne8d4061ba9ee41f989a390e08d55d87a
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013907198
63 https://doi.org/10.1038/bjc.1996.600
64 schema:sdDatePublished 2019-04-11T11:50
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Nba4b8e49a0b341dfad4af0acd90fdd0e
67 schema:url http://www.nature.com/articles/bjc1996600
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N078e2ae92803452784a52c6d563a69f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Nucleoside-Diphosphate Kinase
73 rdf:type schema:DefinedTerm
74 N0d4d28a1450b4aedbf113575c9634282 rdf:first sg:person.01130473444.66
75 rdf:rest Ne5c96fcfc8f144a2bcb1f063ebb83e9c
76 N0e32d509e44646bc984d4d96f861ad65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Breast Neoplasms
78 rdf:type schema:DefinedTerm
79 N0e5aacde5258464ebbe0378859372765 schema:name Unit of Cell and Molecular Analysis, Karolinska Institute and Hospital, Stockholm, Sweden.
80 rdf:type schema:Organization
81 N1cf683efd68b424c902f66a40a6976cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Heat-Shock Proteins
83 rdf:type schema:DefinedTerm
84 N2b53b93363bd4343b4ff024d41848946 rdf:first sg:person.01360376772.70
85 rdf:rest Nc00b3ed8089147958869204a96c2441b
86 N35a7c093d4a248ac8bbdcd030da8bd95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Electrophoresis, Gel, Two-Dimensional
88 rdf:type schema:DefinedTerm
89 N3852b23cb11c48d299b98e55b3601080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Transcription Factors
91 rdf:type schema:DefinedTerm
92 N4779588ecaa24f73bf52fa42a3c1264d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Carcinoma
94 rdf:type schema:DefinedTerm
95 N47e0443e3a9e436eb0776dc5ae2c20ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name NM23 Nucleoside Diphosphate Kinases
97 rdf:type schema:DefinedTerm
98 N5813c1a7c2b54f46ad39dac0a0afc33e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N5c2913d43faa4068a33dc7d5c7818ae3 schema:name nlm_unique_id
102 schema:value 0370635
103 rdf:type schema:PropertyValue
104 N5d6792b63344411c8051740c407148aa rdf:first sg:person.0664140561.45
105 rdf:rest N0d4d28a1450b4aedbf113575c9634282
106 N6a1cc203c8b04bf8a7eda4ea12f80aa3 schema:name readcube_id
107 schema:value 4240017f3df3562c4cd033f786aad65831f6e3d4472aaa2fc49a9e2a02f9c117
108 rdf:type schema:PropertyValue
109 N750d4155e6f74eeaa20bc55533226e93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 N78d92458d1df417c94bb1237ae4a05a5 schema:volumeNumber 74
113 rdf:type schema:PublicationVolume
114 N980798b2a1204622a4bda6557b28e339 rdf:first sg:person.01176606644.55
115 rdf:rest N2b53b93363bd4343b4ff024d41848946
116 N9da4dff773b04425bf64efa8f3c3aefe schema:name dimensions_id
117 schema:value pub.1013907198
118 rdf:type schema:PropertyValue
119 N9e59363b09224d6ebe277ea4eea93f6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cell Cycle Proteins
121 rdf:type schema:DefinedTerm
122 Na709a577a1954d0f9fb1b4e80839c179 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Keratins
124 rdf:type schema:DefinedTerm
125 Nb096c38ba45645df823d857f2de2647c schema:name pubmed_id
126 schema:value 8932346
127 rdf:type schema:PropertyValue
128 Nb313373a93c747e19fd825d79c568a50 rdf:first sg:person.01255225441.66
129 rdf:rest Nfaf6ae89af4546bcb540745cd83deb40
130 Nba4b8e49a0b341dfad4af0acd90fdd0e schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Nc00b3ed8089147958869204a96c2441b rdf:first Nd3271257fb5044e5a47578194522a803
133 rdf:rest N5d6792b63344411c8051740c407148aa
134 Nca3f484f47eb4240b85908985d0c1b6e schema:issueNumber 10
135 rdf:type schema:PublicationIssue
136 Nd03d43b487e64178be7b1ada33a91e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cytoskeletal Proteins
138 rdf:type schema:DefinedTerm
139 Nd3271257fb5044e5a47578194522a803 schema:familyName Uruy
140 schema:givenName K
141 rdf:type schema:Person
142 Nd9343f2c7447432295f7c87b0cb553e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Monomeric GTP-Binding Proteins
144 rdf:type schema:DefinedTerm
145 Nd9afe2494e4c4df2a6e00c61480cd4f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Neoplasm Proteins
147 rdf:type schema:DefinedTerm
148 Nd9b3b1c06b64482cb8c26ba516959f65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Down-Regulation
150 rdf:type schema:DefinedTerm
151 Ndcb55b5741624512b22053bd18ffd5e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Fibroadenoma
153 rdf:type schema:DefinedTerm
154 Ne5c96fcfc8f144a2bcb1f063ebb83e9c rdf:first sg:person.01314041754.28
155 rdf:rest rdf:nil
156 Ne8d4061ba9ee41f989a390e08d55d87a schema:name doi
157 schema:value 10.1038/bjc.1996.600
158 rdf:type schema:PropertyValue
159 Nf393e7140adf4e0b957bf67126300b9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Glutathione Transferase
161 rdf:type schema:DefinedTerm
162 Nfaf6ae89af4546bcb540745cd83deb40 rdf:first sg:person.01050565740.93
163 rdf:rest N980798b2a1204622a4bda6557b28e339
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
168 schema:name Oncology and Carcinogenesis
169 rdf:type schema:DefinedTerm
170 sg:journal.1017082 schema:issn 0007-0920
171 1532-1827
172 schema:name British Journal of Cancer
173 rdf:type schema:Periodical
174 sg:person.01050565740.93 schema:familyName Linder
175 schema:givenName S
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93
177 rdf:type schema:Person
178 sg:person.01130473444.66 schema:familyName Okuzawa
179 schema:givenName K
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130473444.66
181 rdf:type schema:Person
182 sg:person.01176606644.55 schema:familyName Alaiya
183 schema:givenName A A
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176606644.55
185 rdf:type schema:Person
186 sg:person.01255225441.66 schema:affiliation N0e5aacde5258464ebbe0378859372765
187 schema:familyName Franzén
188 schema:givenName B
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66
190 rdf:type schema:Person
191 sg:person.01314041754.28 schema:familyName Auer
192 schema:givenName G
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28
194 rdf:type schema:Person
195 sg:person.01360376772.70 schema:familyName Eriksson
196 schema:givenName E
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360376772.70
198 rdf:type schema:Person
199 sg:person.0664140561.45 schema:familyName Hirano
200 schema:givenName T
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664140561.45
202 rdf:type schema:Person
203 sg:pub.10.1007/bf00662142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004523382
204 https://doi.org/10.1007/bf00662142
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/bjc.1994.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008369910
207 https://doi.org/10.1038/bjc.1994.103
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/bjc.1994.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001764806
210 https://doi.org/10.1038/bjc.1994.99
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/bjc.1996.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005044804
213 https://doi.org/10.1038/bjc.1996.162
214 rdf:type schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1075997376 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1077352140 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1077360823 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1077673765 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1079038759 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1080104193 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1080529965 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1081645831 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082406366 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1082532987 schema:CreativeWork
225 https://doi.org/10.1002/elps.11501401167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049052655
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/elps.1150150157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028789496
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/elps.11501601355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016783346
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0014-4827(79)90529-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019593422
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0014-4827(84)90467-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032604575
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0022-2836(80)90216-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026167304
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/b978-0-12-164720-9.50006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035520994
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.87.6.2319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031316489
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1093/jnci/85.17.1419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818126
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1136/jcp.48.1.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002361457
244 rdf:type schema:CreativeWork
245 https://doi.org/10.3109/10409239309086794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024749967
246 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...