Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-11

AUTHORS

B Franzén, S Linder, A A Alaiya, E Eriksson, K Uruy, T Hirano, K Okuzawa, G Auer

ABSTRACT

Malignant progression of tumour cells is caused by the accumulation of genetic defects, which when combined will generate a large phenotypic diversity. Simultaneous quantitation of a large number of gene products in tumour cells is desirable, but difficult to achieve. We have here quantitated the levels of a number of abundant polypeptides in human breast carcinoma cells using two-dimensional gel electrophoresis (2-DE; PDQUEST). For this purpose, tumour cells were prepared from the tissue of 17 breast carcinomas. Fibroadenoma tissue was used as reference for benign cells. An increase of the spot density of the PCNA polypeptide was observed in rapidly proliferating tumour cells, confirming the validity of the procedures used. In the set of 24 polypeptide spots with known identity, decreases in cytokeratin and tropomyosin levels were observed. The levels of all cytokeratin forms resolved (CK7, CK8, CK15 and CK18) were significantly lower in carcinomas than in fibroadenomas. The levels of tropomyosin 2 and 3 were lower in carcinomas than in fibroadenomas. In contrast, the levels of some members of the stress protein family (pHSP60, HSP90 and calreticulin) were higher in carcinomas. Furthermore, changes in the expression of lactate dehydrogenase and GT-pi, but not in nm23, were observed. We conclude that simultaneous analysis of multiple polypeptides in human carcinomas can be achieved by 2-DE and may be useful in prognostic studies, and that malignant progression of breast carcinomas results in the decreased expression of cytokeratin polypeptides. This phenomenon must be considered in studies where cytokeratins are used as markers to identify the epithelial cell compartment in breast carcinomas. More... »

PAGES

bjc1996600

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1996.600

DOI

http://dx.doi.org/10.1038/bjc.1996.600

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013907198

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8932346


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Gel, Two-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroadenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione Transferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monomeric GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NM23 Nucleoside Diphosphate Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleoside-Diphosphate Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Unit of Cell and Molecular Analysis, Karolinska Institute and Hospital, Stockholm, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franz\u00e9n", 
        "givenName": "B", 
        "id": "sg:person.01255225441.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Linder", 
        "givenName": "S", 
        "id": "sg:person.01050565740.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Alaiya", 
        "givenName": "A A", 
        "id": "sg:person.01176606644.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176606644.55"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Eriksson", 
        "givenName": "E", 
        "id": "sg:person.01360376772.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360376772.70"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Uruy", 
        "givenName": "K", 
        "type": "Person"
      }, 
      {
        "familyName": "Hirano", 
        "givenName": "T", 
        "id": "sg:person.0664140561.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664140561.45"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Okuzawa", 
        "givenName": "K", 
        "id": "sg:person.01130473444.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130473444.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Auer", 
        "givenName": "G", 
        "id": "sg:person.01314041754.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1994.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001764806", 
          "https://doi.org/10.1038/bjc.1994.99"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001764806", 
          "https://doi.org/10.1038/bjc.1994.99"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.48.1.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002361457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00662142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004523382", 
          "https://doi.org/10.1007/bf00662142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00662142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004523382", 
          "https://doi.org/10.1007/bf00662142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005044804", 
          "https://doi.org/10.1038/bjc.1996.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005044804", 
          "https://doi.org/10.1038/bjc.1996.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008369910", 
          "https://doi.org/10.1038/bjc.1994.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008369910", 
          "https://doi.org/10.1038/bjc.1994.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501601355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016783346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501601355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016783346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(79)90529-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019593422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10409239309086794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024749967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(80)90216-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026167304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028789496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150150157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028789496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.6.2319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031316489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(84)90467-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032604575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-164720-9.50006-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035520994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049052655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.11501401167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049052655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.17.1419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075997376", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077352140", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077360823", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077673765", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079038759", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080104193", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080529965", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081645831", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082406366", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082532987", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-11", 
    "datePublishedReg": "1996-11-01", 
    "description": "Malignant progression of tumour cells is caused by the accumulation of genetic defects, which when combined will generate a large phenotypic diversity. Simultaneous quantitation of a large number of gene products in tumour cells is desirable, but difficult to achieve. We have here quantitated the levels of a number of abundant polypeptides in human breast carcinoma cells using two-dimensional gel electrophoresis (2-DE; PDQUEST). For this purpose, tumour cells were prepared from the tissue of 17 breast carcinomas. Fibroadenoma tissue was used as reference for benign cells. An increase of the spot density of the PCNA polypeptide was observed in rapidly proliferating tumour cells, confirming the validity of the procedures used. In the set of 24 polypeptide spots with known identity, decreases in cytokeratin and tropomyosin levels were observed. The levels of all cytokeratin forms resolved (CK7, CK8, CK15 and CK18) were significantly lower in carcinomas than in fibroadenomas. The levels of tropomyosin 2 and 3 were lower in carcinomas than in fibroadenomas. In contrast, the levels of some members of the stress protein family (pHSP60, HSP90 and calreticulin) were higher in carcinomas. Furthermore, changes in the expression of lactate dehydrogenase and GT-pi, but not in nm23, were observed. We conclude that simultaneous analysis of multiple polypeptides in human carcinomas can be achieved by 2-DE and may be useful in prognostic studies, and that malignant progression of breast carcinomas results in the decreased expression of cytokeratin polypeptides. This phenomenon must be considered in studies where cytokeratins are used as markers to identify the epithelial cell compartment in breast carcinomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1996.600", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "74"
      }
    ], 
    "name": "Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins", 
    "pagination": "bjc1996600", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4240017f3df3562c4cd033f786aad65831f6e3d4472aaa2fc49a9e2a02f9c117"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8932346"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1996.600"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013907198"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1996.600", 
      "https://app.dimensions.ai/details/publication/pub.1013907198"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29181_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/bjc1996600"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.600'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      21 PREDICATES      71 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1996.600 schema:about N00f065b5d742473f8bf4330d679dce28
2 N04712decbc7b4ecfa17f718065cb8fc7
3 N08b73a95b1964987b6c44188df492296
4 N1736e9127cd54ac79a2a9e67a4c81009
5 N2b5fe5591c2d4280a32e311a46e81405
6 N5da8423ea6cf48aa8b912d1efe377a03
7 N6319fe5ed8ba4ae483e8a67716ea079c
8 N63602be361c548bbb2061979092750f2
9 N7773857dbbd4491aa01e422ef323807d
10 N7b4ed48f5d7a492ba969c0dea7444d3b
11 N84ac8f7841f34fcd96a94d21e0f95dbf
12 N9eba45030711438fbaddd66da4d7d315
13 Naaef923f48334fa6914134ba20212f24
14 Nbd37ebc7214a40f0a0037cd328da255b
15 Nce33f79467b14a348193d52d27ab587d
16 Nd24bf702cc5343c18abc7d82655d09a0
17 Nff7ae763edf84b1ab595e6103ccb130a
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N4fb26866c43f4fc9b30a6de4dce6b0d0
21 schema:citation sg:pub.10.1007/bf00662142
22 sg:pub.10.1038/bjc.1994.103
23 sg:pub.10.1038/bjc.1994.99
24 sg:pub.10.1038/bjc.1996.162
25 https://app.dimensions.ai/details/publication/pub.1075997376
26 https://app.dimensions.ai/details/publication/pub.1077352140
27 https://app.dimensions.ai/details/publication/pub.1077360823
28 https://app.dimensions.ai/details/publication/pub.1077673765
29 https://app.dimensions.ai/details/publication/pub.1079038759
30 https://app.dimensions.ai/details/publication/pub.1080104193
31 https://app.dimensions.ai/details/publication/pub.1080529965
32 https://app.dimensions.ai/details/publication/pub.1081645831
33 https://app.dimensions.ai/details/publication/pub.1082406366
34 https://app.dimensions.ai/details/publication/pub.1082532987
35 https://doi.org/10.1002/elps.11501401167
36 https://doi.org/10.1002/elps.1150150157
37 https://doi.org/10.1002/elps.11501601355
38 https://doi.org/10.1016/0014-4827(79)90529-9
39 https://doi.org/10.1016/0014-4827(84)90467-1
40 https://doi.org/10.1016/0022-2836(80)90216-8
41 https://doi.org/10.1016/b978-0-12-164720-9.50006-4
42 https://doi.org/10.1073/pnas.87.6.2319
43 https://doi.org/10.1093/jnci/85.17.1419
44 https://doi.org/10.1136/jcp.48.1.26
45 https://doi.org/10.3109/10409239309086794
46 schema:datePublished 1996-11
47 schema:datePublishedReg 1996-11-01
48 schema:description Malignant progression of tumour cells is caused by the accumulation of genetic defects, which when combined will generate a large phenotypic diversity. Simultaneous quantitation of a large number of gene products in tumour cells is desirable, but difficult to achieve. We have here quantitated the levels of a number of abundant polypeptides in human breast carcinoma cells using two-dimensional gel electrophoresis (2-DE; PDQUEST). For this purpose, tumour cells were prepared from the tissue of 17 breast carcinomas. Fibroadenoma tissue was used as reference for benign cells. An increase of the spot density of the PCNA polypeptide was observed in rapidly proliferating tumour cells, confirming the validity of the procedures used. In the set of 24 polypeptide spots with known identity, decreases in cytokeratin and tropomyosin levels were observed. The levels of all cytokeratin forms resolved (CK7, CK8, CK15 and CK18) were significantly lower in carcinomas than in fibroadenomas. The levels of tropomyosin 2 and 3 were lower in carcinomas than in fibroadenomas. In contrast, the levels of some members of the stress protein family (pHSP60, HSP90 and calreticulin) were higher in carcinomas. Furthermore, changes in the expression of lactate dehydrogenase and GT-pi, but not in nm23, were observed. We conclude that simultaneous analysis of multiple polypeptides in human carcinomas can be achieved by 2-DE and may be useful in prognostic studies, and that malignant progression of breast carcinomas results in the decreased expression of cytokeratin polypeptides. This phenomenon must be considered in studies where cytokeratins are used as markers to identify the epithelial cell compartment in breast carcinomas.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N43b0ade14c954c05aeb80db2d520891b
53 N79550e4e04c34d5ca6685ba7e3a56968
54 sg:journal.1017082
55 schema:name Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins
56 schema:pagination bjc1996600
57 schema:productId N4c24d8ae05fb46f6b874cc3999dd8185
58 N5379528b07694e12b943261028961069
59 N7f0e0277437c4525893179d118fbf77c
60 N9b512eb9616648bcbb9e52f343af81da
61 Ncae40ff5b9ef4419ac19b6c193bb1e83
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013907198
63 https://doi.org/10.1038/bjc.1996.600
64 schema:sdDatePublished 2019-04-11T11:50
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N6d190ca2ddd44bc78f63f6a7105bbbf3
67 schema:url http://www.nature.com/articles/bjc1996600
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N00f065b5d742473f8bf4330d679dce28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Glutathione Transferase
73 rdf:type schema:DefinedTerm
74 N04712decbc7b4ecfa17f718065cb8fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Female
76 rdf:type schema:DefinedTerm
77 N08b73a95b1964987b6c44188df492296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Nucleoside-Diphosphate Kinase
79 rdf:type schema:DefinedTerm
80 N1049f78a9774425c8bda983bc12d3dc9 schema:name Unit of Cell and Molecular Analysis, Karolinska Institute and Hospital, Stockholm, Sweden.
81 rdf:type schema:Organization
82 N10b24342772b4d81b237b45de23ab8b8 rdf:first Nc16f63d4654e4564b7192fc3dc68b971
83 rdf:rest Nefd7a26099404a77b7d770135f9a08c7
84 N1736e9127cd54ac79a2a9e67a4c81009 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Fibroadenoma
86 rdf:type schema:DefinedTerm
87 N175fb785552e46d590ade5349ec44cc3 rdf:first sg:person.01314041754.28
88 rdf:rest rdf:nil
89 N2556d88d058c44428d3e0e5ede0f58c5 rdf:first sg:person.01130473444.66
90 rdf:rest N175fb785552e46d590ade5349ec44cc3
91 N2b5fe5591c2d4280a32e311a46e81405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Breast Neoplasms
93 rdf:type schema:DefinedTerm
94 N43b0ade14c954c05aeb80db2d520891b schema:volumeNumber 74
95 rdf:type schema:PublicationVolume
96 N4c24d8ae05fb46f6b874cc3999dd8185 schema:name readcube_id
97 schema:value 4240017f3df3562c4cd033f786aad65831f6e3d4472aaa2fc49a9e2a02f9c117
98 rdf:type schema:PropertyValue
99 N4fb26866c43f4fc9b30a6de4dce6b0d0 rdf:first sg:person.01255225441.66
100 rdf:rest N8f1243cef19a464baaae6c0a7c18518b
101 N5379528b07694e12b943261028961069 schema:name pubmed_id
102 schema:value 8932346
103 rdf:type schema:PropertyValue
104 N5da8423ea6cf48aa8b912d1efe377a03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cytoskeletal Proteins
106 rdf:type schema:DefinedTerm
107 N5fae414f469542afa115a3bf9c97f0ec rdf:first sg:person.01176606644.55
108 rdf:rest N94b2b536e06c4a299337fc012c1e83f6
109 N6319fe5ed8ba4ae483e8a67716ea079c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Neoplasm Proteins
111 rdf:type schema:DefinedTerm
112 N63602be361c548bbb2061979092750f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Transcription Factors
114 rdf:type schema:DefinedTerm
115 N6d190ca2ddd44bc78f63f6a7105bbbf3 schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N7773857dbbd4491aa01e422ef323807d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Keratins
119 rdf:type schema:DefinedTerm
120 N79550e4e04c34d5ca6685ba7e3a56968 schema:issueNumber 10
121 rdf:type schema:PublicationIssue
122 N7b4ed48f5d7a492ba969c0dea7444d3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Monomeric GTP-Binding Proteins
124 rdf:type schema:DefinedTerm
125 N7f0e0277437c4525893179d118fbf77c schema:name doi
126 schema:value 10.1038/bjc.1996.600
127 rdf:type schema:PropertyValue
128 N84ac8f7841f34fcd96a94d21e0f95dbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Cycle Proteins
130 rdf:type schema:DefinedTerm
131 N8f1243cef19a464baaae6c0a7c18518b rdf:first sg:person.01050565740.93
132 rdf:rest N5fae414f469542afa115a3bf9c97f0ec
133 N94b2b536e06c4a299337fc012c1e83f6 rdf:first sg:person.01360376772.70
134 rdf:rest N10b24342772b4d81b237b45de23ab8b8
135 N9b512eb9616648bcbb9e52f343af81da schema:name nlm_unique_id
136 schema:value 0370635
137 rdf:type schema:PropertyValue
138 N9eba45030711438fbaddd66da4d7d315 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name NM23 Nucleoside Diphosphate Kinases
140 rdf:type schema:DefinedTerm
141 Naaef923f48334fa6914134ba20212f24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Carcinoma
143 rdf:type schema:DefinedTerm
144 Nbd37ebc7214a40f0a0037cd328da255b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Down-Regulation
146 rdf:type schema:DefinedTerm
147 Nc16f63d4654e4564b7192fc3dc68b971 schema:familyName Uruy
148 schema:givenName K
149 rdf:type schema:Person
150 Ncae40ff5b9ef4419ac19b6c193bb1e83 schema:name dimensions_id
151 schema:value pub.1013907198
152 rdf:type schema:PropertyValue
153 Nce33f79467b14a348193d52d27ab587d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Heat-Shock Proteins
155 rdf:type schema:DefinedTerm
156 Nd24bf702cc5343c18abc7d82655d09a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Humans
158 rdf:type schema:DefinedTerm
159 Nefd7a26099404a77b7d770135f9a08c7 rdf:first sg:person.0664140561.45
160 rdf:rest N2556d88d058c44428d3e0e5ede0f58c5
161 Nff7ae763edf84b1ab595e6103ccb130a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Electrophoresis, Gel, Two-Dimensional
163 rdf:type schema:DefinedTerm
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
168 schema:name Oncology and Carcinogenesis
169 rdf:type schema:DefinedTerm
170 sg:journal.1017082 schema:issn 0007-0920
171 1532-1827
172 schema:name British Journal of Cancer
173 rdf:type schema:Periodical
174 sg:person.01050565740.93 schema:familyName Linder
175 schema:givenName S
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93
177 rdf:type schema:Person
178 sg:person.01130473444.66 schema:familyName Okuzawa
179 schema:givenName K
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130473444.66
181 rdf:type schema:Person
182 sg:person.01176606644.55 schema:familyName Alaiya
183 schema:givenName A A
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176606644.55
185 rdf:type schema:Person
186 sg:person.01255225441.66 schema:affiliation N1049f78a9774425c8bda983bc12d3dc9
187 schema:familyName Franzén
188 schema:givenName B
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66
190 rdf:type schema:Person
191 sg:person.01314041754.28 schema:familyName Auer
192 schema:givenName G
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28
194 rdf:type schema:Person
195 sg:person.01360376772.70 schema:familyName Eriksson
196 schema:givenName E
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360376772.70
198 rdf:type schema:Person
199 sg:person.0664140561.45 schema:familyName Hirano
200 schema:givenName T
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664140561.45
202 rdf:type schema:Person
203 sg:pub.10.1007/bf00662142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004523382
204 https://doi.org/10.1007/bf00662142
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/bjc.1994.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008369910
207 https://doi.org/10.1038/bjc.1994.103
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/bjc.1994.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001764806
210 https://doi.org/10.1038/bjc.1994.99
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/bjc.1996.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005044804
213 https://doi.org/10.1038/bjc.1996.162
214 rdf:type schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1075997376 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1077352140 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1077360823 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1077673765 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1079038759 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1080104193 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1080529965 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1081645831 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082406366 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1082532987 schema:CreativeWork
225 https://doi.org/10.1002/elps.11501401167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049052655
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/elps.1150150157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028789496
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/elps.11501601355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016783346
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0014-4827(79)90529-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019593422
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0014-4827(84)90467-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032604575
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0022-2836(80)90216-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026167304
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/b978-0-12-164720-9.50006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035520994
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.87.6.2319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031316489
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1093/jnci/85.17.1419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818126
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1136/jcp.48.1.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002361457
244 rdf:type schema:CreativeWork
245 https://doi.org/10.3109/10409239309086794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024749967
246 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...