Combination toxicity of etoposide (VP-16) and photosensitisation with a water-soluble aluminium phthalocyanine in K562 human leukaemic cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-11

AUTHORS

T G Gantchev, N Brasseur, J E van Lier

ABSTRACT

Etoposide (VP-16) is an anti-cancer drug commonly used against several types of tumours and leukaemia, either alone or in combination chemotherapy. Photodynamic therapy (PDT) is another, relatively new modality for treatment of various malignancies. The interactions between VP-16 and PDT, using aluminium tetrasulphophthalocyanine as photosensitiser, in K562 human leukaemic cells were investigated. Cell responses to individual and combined drug treatment under different experimental conditions revealed synergistic drug toxicity. The latter was evident from various events of cell response, including supra-additive accumulation of cells in G2/M cell cycle phase and endonucleolytic DNA fragmentation (apoptosis). The involvement of the cellular antioxidant system in the synergistic interactions of photosensitisation and VP-16 is proposed. More... »

PAGES

1570

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1996.591

DOI

http://dx.doi.org/10.1038/bjc.1996.591

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026491836

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8932337


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