Continuous infusion or subcutaneous injection of granulocyte-macrophage colony-stimulating factor: increased efficacy and reduced toxicity when given subcutaneously View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-10

AUTHORS

A H Honkoop, K Hoekman, J Wagstaff, C J van Groeningen, J B Vermorken, E Boven, H M Pinedo

ABSTRACT

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a haematopoietic growth factor with a wide variety of applications in the clinic. In early phase I studies the continuous intravenous (c.i.) route of administration was often used. Later it was shown that subcutaneous (s.c.) administration was also effective. The optimal route of administration remains, however, poorly defined, and no studies have made a direct comparison between these two routes of administration. We treated patients with advanced breast cancer with moderately high-dose doxorubicin and cylophosphamide and GM-CSF. The first 14 patients received GM-CSF by c.i, while subsequently 47 patients received it s.c. Comparison between the two groups showed that c.i. GM-CSF was more toxic in several respects. There was a higher need for erythrocyte and platelet transfusions and a significant deterioration in the performance status. This study indicates that subcutaneous GM-CSF is the preferred route of administration. Randomised trials are, however, needed to confirm these conclusions. More... »

PAGES

1132

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1996.502

DOI

http://dx.doi.org/10.1038/bjc.1996.502

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010877355

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8855987


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Component Transfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Doxorubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granulocyte-Macrophage Colony-Stimulating Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Subcutaneous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutropenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, University Hospital Vrije Universiteit Amsterdam, Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Honkoop", 
        "givenName": "A H", 
        "id": "sg:person.0634710647.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634710647.83"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hoekman", 
        "givenName": "K", 
        "id": "sg:person.0701655230.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701655230.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wagstaff", 
        "givenName": "J", 
        "id": "sg:person.01071132724.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071132724.32"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "van Groeningen", 
        "givenName": "C J", 
        "id": "sg:person.01072777672.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072777672.33"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Vermorken", 
        "givenName": "J B", 
        "id": "sg:person.0653351227.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653351227.67"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Boven", 
        "givenName": "E", 
        "id": "sg:person.0750210307.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750210307.96"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pinedo", 
        "givenName": "H M", 
        "id": "sg:person.013437631522.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013437631522.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1994.tb01617.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003027123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003992752", 
          "https://doi.org/10.1038/bjc.1994.71"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003992752", 
          "https://doi.org/10.1038/bjc.1994.71"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004113040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198804073181401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005034550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)90711-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007907687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)90711-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007907687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198809083191001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008155713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0030-4220(79)90230-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009464082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0030-4220(79)90230-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009464082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198712173172501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015951734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1992.tb08891.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018024778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198709033171003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021776273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1989.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022624090", 
          "https://doi.org/10.1038/bjc.1989.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1989.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022624090", 
          "https://doi.org/10.1038/bjc.1989.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)91103-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023600144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)91103-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023600144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199106203242504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027529038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)90594-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041783932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)90594-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041783932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.163.3.740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050898099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clinids/12.1.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059471177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/81.19.1510-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059815381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/83.21.1546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059816860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-110-5-357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073693792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077948809", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1991.9.6.929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078132257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078788082", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079520664", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079524371", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079574506", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079665937", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082467307", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a058975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082525466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082534483", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082558939", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1994.12.9.1917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082563756"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-10", 
    "datePublishedReg": "1996-10-01", 
    "description": "Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a haematopoietic growth factor with a wide variety of applications in the clinic. In early phase I studies the continuous intravenous (c.i.) route of administration was often used. Later it was shown that subcutaneous (s.c.) administration was also effective. The optimal route of administration remains, however, poorly defined, and no studies have made a direct comparison between these two routes of administration. We treated patients with advanced breast cancer with moderately high-dose doxorubicin and cylophosphamide and GM-CSF. The first 14 patients received GM-CSF by c.i, while subsequently 47 patients received it s.c. Comparison between the two groups showed that c.i. GM-CSF was more toxic in several respects. There was a higher need for erythrocyte and platelet transfusions and a significant deterioration in the performance status. This study indicates that subcutaneous GM-CSF is the preferred route of administration. Randomised trials are, however, needed to confirm these conclusions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1996.502", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "74"
      }
    ], 
    "name": "Continuous infusion or subcutaneous injection of granulocyte-macrophage colony-stimulating factor: increased efficacy and reduced toxicity when given subcutaneously", 
    "pagination": "1132", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "33d2a7e029ff38c6743140b86a566987e2d7b8d7911f33ffdcd0886e18d7e1b7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8855987"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1996.502"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010877355"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1996.502", 
      "https://app.dimensions.ai/details/publication/pub.1010877355"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29182_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc1996502"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.502'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.502'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.502'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.502'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      74 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1996.502 schema:about N1990167e8e434adea299e4f9002395f6
2 N216d472d5ddb401cb47fd858e23ac3af
3 N4c1cfe65fef840959d34f85e0c7b16b4
4 N56b81f47e899450b8347830748e0499c
5 N803490e94eee4670aba994153ac9aec4
6 N8274b390afda4944b03548f24f5acd70
7 N83e2e20005dc4badbb325406fe6330ea
8 Na2f1c4e50cc5487294975970166d4c1e
9 Na81bd9aaf8ee4fd6afffc1531db36a5f
10 Na9fec023dff5497f8596b82140a03c26
11 Nd2c03f94253f4592a9cb562c5d41a4d1
12 Neebed39a361f4174be31c331a9e870bb
13 Nf8e0a9ca8aca4bcca3f915270a4793e9
14 Nfe3ea24e425f4d7caed1107a7b155449
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N2cde6cde844f423fa40c4ed5984dce40
18 schema:citation sg:pub.10.1038/bjc.1989.28
19 sg:pub.10.1038/bjc.1994.71
20 https://app.dimensions.ai/details/publication/pub.1077948809
21 https://app.dimensions.ai/details/publication/pub.1078788082
22 https://app.dimensions.ai/details/publication/pub.1079520664
23 https://app.dimensions.ai/details/publication/pub.1079524371
24 https://app.dimensions.ai/details/publication/pub.1079574506
25 https://app.dimensions.ai/details/publication/pub.1079665937
26 https://app.dimensions.ai/details/publication/pub.1082467307
27 https://app.dimensions.ai/details/publication/pub.1082534483
28 https://app.dimensions.ai/details/publication/pub.1082558939
29 https://doi.org/10.1016/0030-4220(79)90230-5
30 https://doi.org/10.1016/0140-6736(91)90594-f
31 https://doi.org/10.1016/0140-6736(91)91103-2
32 https://doi.org/10.1016/s0140-6736(89)90711-3
33 https://doi.org/10.1056/nejm198709033171003
34 https://doi.org/10.1056/nejm198712173172501
35 https://doi.org/10.1056/nejm198804073181401
36 https://doi.org/10.1056/nejm198809083191001
37 https://doi.org/10.1056/nejm199106203242504
38 https://doi.org/10.1084/jem.163.3.740
39 https://doi.org/10.1093/clinids/12.1.41
40 https://doi.org/10.1093/jnci/81.19.1510-a
41 https://doi.org/10.1093/jnci/83.21.1546
42 https://doi.org/10.1093/oxfordjournals.annonc.a058975
43 https://doi.org/10.1111/j.1365-2141.1992.tb08891.x
44 https://doi.org/10.1111/j.1600-0609.1994.tb01617.x
45 https://doi.org/10.1172/jci114559
46 https://doi.org/10.1200/jco.1991.9.6.929
47 https://doi.org/10.1200/jco.1994.12.9.1917
48 https://doi.org/10.7326/0003-4819-110-5-357
49 schema:datePublished 1996-10
50 schema:datePublishedReg 1996-10-01
51 schema:description Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a haematopoietic growth factor with a wide variety of applications in the clinic. In early phase I studies the continuous intravenous (c.i.) route of administration was often used. Later it was shown that subcutaneous (s.c.) administration was also effective. The optimal route of administration remains, however, poorly defined, and no studies have made a direct comparison between these two routes of administration. We treated patients with advanced breast cancer with moderately high-dose doxorubicin and cylophosphamide and GM-CSF. The first 14 patients received GM-CSF by c.i, while subsequently 47 patients received it s.c. Comparison between the two groups showed that c.i. GM-CSF was more toxic in several respects. There was a higher need for erythrocyte and platelet transfusions and a significant deterioration in the performance status. This study indicates that subcutaneous GM-CSF is the preferred route of administration. Randomised trials are, however, needed to confirm these conclusions.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf Nf7763e3383d547b0a4cd91e85d174ca0
56 Nfe51258467be4fd3ae2a76686919987f
57 sg:journal.1017082
58 schema:name Continuous infusion or subcutaneous injection of granulocyte-macrophage colony-stimulating factor: increased efficacy and reduced toxicity when given subcutaneously
59 schema:pagination 1132
60 schema:productId N446a9887379a40b98f61cb0c63ef64f4
61 N56f7388027d74832b93f6550683b3d7b
62 N870ea3f26e0240f9882fad13d01de0d4
63 Na1bc97016c2e4dc782adaaef47722118
64 Nd70f66c12be341d2bf42a2a54b32601a
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010877355
66 https://doi.org/10.1038/bjc.1996.502
67 schema:sdDatePublished 2019-04-11T11:50
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Ncffd986bfbcd43b590aaf498cd5b224b
70 schema:url https://www.nature.com/articles/bjc1996502
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N1990167e8e434adea299e4f9002395f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Injections, Subcutaneous
76 rdf:type schema:DefinedTerm
77 N216d472d5ddb401cb47fd858e23ac3af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Neutropenia
79 rdf:type schema:DefinedTerm
80 N284443a7357d4ed6b038db2a67b2be58 rdf:first sg:person.0701655230.21
81 rdf:rest Nc7a24afa4469445bb54993617408d122
82 N2cde6cde844f423fa40c4ed5984dce40 rdf:first sg:person.0634710647.83
83 rdf:rest N284443a7357d4ed6b038db2a67b2be58
84 N30961e2603474bd38d01653a43c56b5d rdf:first sg:person.0653351227.67
85 rdf:rest Nb969c1891c3b44aab10dc26fb1f2d5d0
86 N446a9887379a40b98f61cb0c63ef64f4 schema:name pubmed_id
87 schema:value 8855987
88 rdf:type schema:PropertyValue
89 N4c1cfe65fef840959d34f85e0c7b16b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Doxorubicin
91 rdf:type schema:DefinedTerm
92 N56b81f47e899450b8347830748e0499c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Humans
94 rdf:type schema:DefinedTerm
95 N56f7388027d74832b93f6550683b3d7b schema:name readcube_id
96 schema:value 33d2a7e029ff38c6743140b86a566987e2d7b8d7911f33ffdcd0886e18d7e1b7
97 rdf:type schema:PropertyValue
98 N803490e94eee4670aba994153ac9aec4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Infusions, Intravenous
100 rdf:type schema:DefinedTerm
101 N8274b390afda4944b03548f24f5acd70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Breast Neoplasms
103 rdf:type schema:DefinedTerm
104 N83e2e20005dc4badbb325406fe6330ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Blood Component Transfusion
106 rdf:type schema:DefinedTerm
107 N870ea3f26e0240f9882fad13d01de0d4 schema:name doi
108 schema:value 10.1038/bjc.1996.502
109 rdf:type schema:PropertyValue
110 N9b4cacf56ed34051a48357a23f8ff609 rdf:first sg:person.013437631522.70
111 rdf:rest rdf:nil
112 Na1bc97016c2e4dc782adaaef47722118 schema:name nlm_unique_id
113 schema:value 0370635
114 rdf:type schema:PropertyValue
115 Na2f1c4e50cc5487294975970166d4c1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Remission Induction
117 rdf:type schema:DefinedTerm
118 Na81bd9aaf8ee4fd6afffc1531db36a5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Antineoplastic Combined Chemotherapy Protocols
120 rdf:type schema:DefinedTerm
121 Na9fec023dff5497f8596b82140a03c26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Adult
123 rdf:type schema:DefinedTerm
124 Nb969c1891c3b44aab10dc26fb1f2d5d0 rdf:first sg:person.0750210307.96
125 rdf:rest N9b4cacf56ed34051a48357a23f8ff609
126 Nc6bca9a41cae4269b25244f1d2fe35b9 rdf:first sg:person.01072777672.33
127 rdf:rest N30961e2603474bd38d01653a43c56b5d
128 Nc7a24afa4469445bb54993617408d122 rdf:first sg:person.01071132724.32
129 rdf:rest Nc6bca9a41cae4269b25244f1d2fe35b9
130 Ncffd986bfbcd43b590aaf498cd5b224b schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Nd2c03f94253f4592a9cb562c5d41a4d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Middle Aged
134 rdf:type schema:DefinedTerm
135 Nd70f66c12be341d2bf42a2a54b32601a schema:name dimensions_id
136 schema:value pub.1010877355
137 rdf:type schema:PropertyValue
138 Neebed39a361f4174be31c331a9e870bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Female
140 rdf:type schema:DefinedTerm
141 Nf7763e3383d547b0a4cd91e85d174ca0 schema:volumeNumber 74
142 rdf:type schema:PublicationVolume
143 Nf8e0a9ca8aca4bcca3f915270a4793e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Granulocyte-Macrophage Colony-Stimulating Factor
145 rdf:type schema:DefinedTerm
146 Nfe3ea24e425f4d7caed1107a7b155449 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cyclophosphamide
148 rdf:type schema:DefinedTerm
149 Nfe51258467be4fd3ae2a76686919987f schema:issueNumber 7
150 rdf:type schema:PublicationIssue
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
155 schema:name Clinical Sciences
156 rdf:type schema:DefinedTerm
157 sg:journal.1017082 schema:issn 0007-0920
158 1532-1827
159 schema:name British Journal of Cancer
160 rdf:type schema:Periodical
161 sg:person.01071132724.32 schema:familyName Wagstaff
162 schema:givenName J
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071132724.32
164 rdf:type schema:Person
165 sg:person.01072777672.33 schema:familyName van Groeningen
166 schema:givenName C J
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072777672.33
168 rdf:type schema:Person
169 sg:person.013437631522.70 schema:familyName Pinedo
170 schema:givenName H M
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013437631522.70
172 rdf:type schema:Person
173 sg:person.0634710647.83 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
174 schema:familyName Honkoop
175 schema:givenName A H
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634710647.83
177 rdf:type schema:Person
178 sg:person.0653351227.67 schema:familyName Vermorken
179 schema:givenName J B
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653351227.67
181 rdf:type schema:Person
182 sg:person.0701655230.21 schema:familyName Hoekman
183 schema:givenName K
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701655230.21
185 rdf:type schema:Person
186 sg:person.0750210307.96 schema:familyName Boven
187 schema:givenName E
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750210307.96
189 rdf:type schema:Person
190 sg:pub.10.1038/bjc.1989.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022624090
191 https://doi.org/10.1038/bjc.1989.28
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/bjc.1994.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003992752
194 https://doi.org/10.1038/bjc.1994.71
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1077948809 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1078788082 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1079520664 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1079524371 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1079574506 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1079665937 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1082467307 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1082534483 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1082558939 schema:CreativeWork
205 https://doi.org/10.1016/0030-4220(79)90230-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009464082
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0140-6736(91)90594-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1041783932
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0140-6736(91)91103-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023600144
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0140-6736(89)90711-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007907687
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1056/nejm198709033171003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021776273
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1056/nejm198712173172501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015951734
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1056/nejm198804073181401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005034550
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1056/nejm198809083191001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008155713
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1056/nejm199106203242504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027529038
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1084/jem.163.3.740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050898099
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1093/clinids/12.1.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059471177
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1093/jnci/81.19.1510-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1059815381
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/jnci/83.21.1546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059816860
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/oxfordjournals.annonc.a058975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082525466
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1111/j.1365-2141.1992.tb08891.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018024778
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/j.1600-0609.1994.tb01617.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003027123
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1172/jci114559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004113040
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1200/jco.1991.9.6.929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078132257
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1200/jco.1994.12.9.1917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082563756
242 rdf:type schema:CreativeWork
243 https://doi.org/10.7326/0003-4819-110-5-357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073693792
244 rdf:type schema:CreativeWork
245 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
246 schema:name Department of Medical Oncology, University Hospital Vrije Universiteit Amsterdam, Netherlands.
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...