Ontology type: schema:ScholarlyArticle Open Access: True
1996-01
AUTHORSAL Smith, J Hung, L Walker, TE Rogers, F Vuitch, E Lee, AF Gazdar
ABSTRACTAccording to the field cancerisation theory the entire upper aerodigestive tract has been mutagenised, thereby placing the affected individual at risk for the development of one or more cancers. To investigate this concept we studied the respiratory epithelium in lungs bearing cancer, including bronchi, bronchioles and alveoli. After identifying preneoplastic and preinvasive lesions by light microscopy, we determined the DNA content of their nuclei in Feulgen-stained sections using a high-performance digitised image analyser. Archival material from 35 resected cases of non-small-cell lung cancer (NSCLC) was selected, including 16 central tumours (mainly squamous cell carcinomas) and 19 peripheral tumours (mainly adenocarcinomas) and five resected cases of metastatic tumour from extrathoracic primary sites. Of the NSCLCs, 31/35 (89%) were aneuploid, as were 60% of the metastases from extrathoracic sites. Multiple, focal areas of preneoplasia or preinvasive carcinoma were present in the selected cases. The lesions ranged in severity from hyperplasia through metaplasia and dysplasia to carcinoma in situ. Aneuploid preinvasive lesions were not noted in association with the four diploid tumours but were present only when the accompanying NSCLC was aneuploid. With both central and peripheral tumours, aneuploid preneoplastic lesions were more frequent in the peripheral parts of the lung (bronchioles or alveoli) than in the central bronchi. Both the degree and incidence of aneuploidy increased with progressive severity of morphological change. Aneuploidy was not found in preinvasive lesions accompanying the five metastatic cases. Our findings provide strong support for the concept of field cancerisation. More... »
PAGES203-209
http://scigraph.springernature.com/pub.10.1038/bjc.1996.36
DOIhttp://dx.doi.org/10.1038/bjc.1996.36
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1047250652
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8546907
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenocarcinoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aneuploidy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bronchi",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma in Situ",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Non-Small-Cell Lung",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Squamous Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chi-Square Distribution",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epithelium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperplasia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Image Interpretation, Computer-Assisted",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Metaplasia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Invasiveness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Precancerous Conditions",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Simmons Cancer Center, University of Texas, Dallas, USA",
"id": "http://www.grid.ac/institutes/grid.267313.2",
"name": [
"Simmons Cancer Center, University of Texas, Dallas, USA"
],
"type": "Organization"
},
"familyName": "Smith",
"givenName": "AL",
"id": "sg:person.01356356734.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356356734.42"
],
"type": "Person"
},
{
"familyName": "Hung",
"givenName": "J",
"id": "sg:person.0724626156.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724626156.04"
],
"type": "Person"
},
{
"familyName": "Walker",
"givenName": "L",
"type": "Person"
},
{
"familyName": "Rogers",
"givenName": "TE",
"id": "sg:person.0734125605.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734125605.61"
],
"type": "Person"
},
{
"familyName": "Vuitch",
"givenName": "F",
"id": "sg:person.0661514543.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661514543.91"
],
"type": "Person"
},
{
"familyName": "Lee",
"givenName": "E",
"type": "Person"
},
{
"familyName": "Gazdar",
"givenName": "AF",
"id": "sg:person.01351741346.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351741346.88"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf01600250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044861322",
"https://doi.org/10.1007/bf01600250"
],
"type": "CreativeWork"
}
],
"datePublished": "1996-01",
"datePublishedReg": "1996-01-01",
"description": "According to the field cancerisation theory the entire upper aerodigestive tract has been mutagenised, thereby placing the affected individual at risk for the development of one or more cancers. To investigate this concept we studied the respiratory epithelium in lungs bearing cancer, including bronchi, bronchioles and alveoli. After identifying preneoplastic and preinvasive lesions by light microscopy, we determined the DNA content of their nuclei in Feulgen-stained sections using a high-performance digitised image analyser. Archival material from 35 resected cases of non-small-cell lung cancer (NSCLC) was selected, including 16 central tumours (mainly squamous cell carcinomas) and 19 peripheral tumours (mainly adenocarcinomas) and five resected cases of metastatic tumour from extrathoracic primary sites. Of the NSCLCs, 31/35 (89%) were aneuploid, as were 60% of the metastases from extrathoracic sites. Multiple, focal areas of preneoplasia or preinvasive carcinoma were present in the selected cases. The lesions ranged in severity from hyperplasia through metaplasia and dysplasia to carcinoma in situ. Aneuploid preinvasive lesions were not noted in association with the four diploid tumours but were present only when the accompanying NSCLC was aneuploid. With both central and peripheral tumours, aneuploid preneoplastic lesions were more frequent in the peripheral parts of the lung (bronchioles or alveoli) than in the central bronchi. Both the degree and incidence of aneuploidy increased with progressive severity of morphological change. Aneuploidy was not found in preinvasive lesions accompanying the five metastatic cases. Our findings provide strong support for the concept of field cancerisation.",
"genre": "article",
"id": "sg:pub.10.1038/bjc.1996.36",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "73"
}
],
"keywords": [
"preinvasive lesions",
"peripheral tumors",
"respiratory epithelium",
"entire upper aerodigestive tract",
"upper aerodigestive tract",
"cell lung cancer",
"lung cancer patients",
"incidence of aneuploidy",
"aerodigestive tract",
"central bronchi",
"central tumors",
"extrathoracic sites",
"preinvasive carcinoma",
"diploid tumors",
"field cancerisation",
"lung cancer",
"metastatic tumors",
"metastatic cases",
"cancer patients",
"progressive severity",
"more cancers",
"preneoplastic lesions",
"primary site",
"lesions",
"tumors",
"cancer",
"focal areas",
"bronchus",
"carcinoma",
"lung",
"epithelium",
"severity",
"aneuploidy",
"peripheral part",
"morphological changes",
"light microscopy",
"DNA content",
"image analyzer",
"NSCLC",
"metaplasia",
"patients",
"NSCLCs",
"cancerisation",
"hyperplasia",
"bronchioles",
"metastasis",
"dysplasia",
"cases",
"preneoplasia",
"incidence",
"tract",
"alveoli",
"risk",
"association",
"findings",
"individuals",
"Feulgen",
"sites",
"nucleus",
"extensive areas",
"area",
"changes",
"strong support",
"support",
"development",
"degree",
"sections",
"part",
"situ",
"analyzer",
"content",
"archival material",
"microscopy",
"materials",
"concept",
"theory"
],
"name": "Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients",
"pagination": "203-209",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1047250652"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/bjc.1996.36"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"8546907"
]
}
],
"sameAs": [
"https://doi.org/10.1038/bjc.1996.36",
"https://app.dimensions.ai/details/publication/pub.1047250652"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_280.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/bjc.1996.36"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.36'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.36'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.36'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1996.36'
This table displays all metadata directly associated to this object as RDF triples.
264 TRIPLES
22 PREDICATES
126 URIs
117 LITERALS
29 BLANK NODES