Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1995-12

AUTHORS

SJ Vermeulen, EA Bruyneel, FM van Roy, MM Mareel, ME Bracke

ABSTRACT

All-trans-retinoic acid (RA), like insulin-like growth factor I (IGF-I) and tamoxifen, inhibit invasion of human MCF-7/6 mammary cancer cells in vitro. For tamoxifen and for IGF-I, activation of the invasion-suppressor function of the E-cadherin/catenin complex was shown to be the most probable mechanism of the anti-invasive action. We did a series of experiments to determine whether the anti-invasive effect of RA also implicated the invasion-suppressor E-cadherin/catenin complex. Human MCF-7/6 mammary and HCT-8/R1 colon cancer cells, both with a dysfunctional E-cadherin/catenin complex, were treated with RA and the function of the complex was evaluated through Ca(2+)-dependent fast aggregation. Fast aggregation of both MCF-7/6 and HCT-8/R1 cells was induced by 1 microM RA. This effect was abolished by antibodies against E-cadherin. RA-induced fast aggregation was not sensitive to cycloheximide, tyrosine kinase inhibitors or antibodies against IGF-I or against the IGF-I receptor. RA did not stimulate IGF-I receptor phosphorylation or alter the E-cadherin/catenin complex, as evidenced by immunoprecipitation. RA up-regulates the function of the invasion-suppressor complex E-cadherin/catenin. Its action mechanism is different from that of IGF-I. RA may act as an anti-invasive agent with unique mechanisms of action. More... »

PAGES

1447-1453

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1995.528

DOI

http://dx.doi.org/10.1038/bjc.1995.528

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027611152

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8519658


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