Comparison of basic fibroblast growth factor levels in clone A human colon cancer cells in vitro with levels in xenografted ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1995-07

AUTHORS

L P McCarty, S M Karr, B Z Harris, S G Michelson, J T Leith

ABSTRACT

We measured levels of basic fibroblast growth factor (FGF-2) in human colon cancer cells (clone A) in vitro and in xenografted solid tumours using a commercial enzyme-linked immunoassay. In Vitro, levels in unfed plateau phase or exponentially growing cells were low, averaging respectively about 2 and 8 pg 10(-6) cells. However, when solid tumours (average volumes 787 mm3) were cut into halves and either enzymatically disaggregated to obtain a cellular fraction or extracted in toto, levels were much higher. In the cellular fraction, values averaged 110 pg 10(-6) cells, while in whole tumour extracts, average values were 24 pg mg-1 tumour tissue. These results indicate that growth factor levels in solid neoplasms may differ markedly from those predicted from in vitro measurements. We hypothesise that the apparent increase in FGF-2 levels in vivo results primarily from the presence of a significant fraction of host cells (in particular, macrophages, which may contain high levels of FGF-2) within xenografted clone A neoplasms. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1995.269

DOI

http://dx.doi.org/10.1038/bjc.1995.269

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032864627

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7599036


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblast Growth Factor 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Brown University", 
          "id": "https://www.grid.ac/institutes/grid.40263.33", 
          "name": [
            "Department of Radiation Medicine, Brown University School of Medicine, Providence, Rhode Island 02912, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCarty", 
        "givenName": "L P", 
        "type": "Person"
      }, 
      {
        "familyName": "Karr", 
        "givenName": "S M", 
        "type": "Person"
      }, 
      {
        "familyName": "Harris", 
        "givenName": "B Z", 
        "type": "Person"
      }, 
      {
        "familyName": "Michelson", 
        "givenName": "S G", 
        "id": "sg:person.01131470600.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131470600.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Leith", 
        "givenName": "J T", 
        "id": "sg:person.0727651021.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727651021.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1981.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001461538", 
          "https://doi.org/10.1038/bjc.1981.154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1981.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001461538", 
          "https://doi.org/10.1038/bjc.1981.154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240450208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001955515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240450208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001955515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0676.1991.tb00529.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004525119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0676.1991.tb00529.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004525119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08977199309010832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006217565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(92)92277-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007190977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02460696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009710397", 
          "https://doi.org/10.1007/bf02460696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02460696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009710397", 
          "https://doi.org/10.1007/bf02460696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011468953", 
          "https://doi.org/10.1038/bjc.1993.418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011468953", 
          "https://doi.org/10.1038/bjc.1993.418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012647208", 
          "https://doi.org/10.1038/bjc.1992.268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012647208", 
          "https://doi.org/10.1038/bjc.1992.268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(85)90038-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017805640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1994.tb01387.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018249206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1977.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024189985", 
          "https://doi.org/10.1038/bjc.1977.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1977.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024189985", 
          "https://doi.org/10.1038/bjc.1977.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)90837-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026657487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)90837-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026657487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359843a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028884048", 
          "https://doi.org/10.1038/359843a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1987.tb01356.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032000232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(79)90647-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033567986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(79)90647-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033567986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041290220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034497177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1163/156856293x00096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038545503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08977199309029135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038842369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910440120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039962719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(81)90312-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042804098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08977198809000242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042995162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(85)90614-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044897839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-8140(91)90341-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047280357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02460621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595657", 
          "https://doi.org/10.1007/bf02460621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02460621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595657", 
          "https://doi.org/10.1007/bf02460621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-7207(92)90007-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049449778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-7207(92)90007-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049449778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/27.7.1214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059487860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/82.24.1890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059816209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.2.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.3.241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/86.10.742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/86.5.356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059819127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3137658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062593394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3137658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062593394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.12-10-03828.1992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076202631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077833245", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079701261", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/78.2.371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079767308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079959674", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081866744", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082708503", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082716798", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082720100", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082775304", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082927653", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-07", 
    "datePublishedReg": "1995-07-01", 
    "description": "We measured levels of basic fibroblast growth factor (FGF-2) in human colon cancer cells (clone A) in vitro and in xenografted solid tumours using a commercial enzyme-linked immunoassay. In Vitro, levels in unfed plateau phase or exponentially growing cells were low, averaging respectively about 2 and 8 pg 10(-6) cells. However, when solid tumours (average volumes 787 mm3) were cut into halves and either enzymatically disaggregated to obtain a cellular fraction or extracted in toto, levels were much higher. In the cellular fraction, values averaged 110 pg 10(-6) cells, while in whole tumour extracts, average values were 24 pg mg-1 tumour tissue. These results indicate that growth factor levels in solid neoplasms may differ markedly from those predicted from in vitro measurements. We hypothesise that the apparent increase in FGF-2 levels in vivo results primarily from the presence of a significant fraction of host cells (in particular, macrophages, which may contain high levels of FGF-2) within xenografted clone A neoplasms.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1995.269", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2470249", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "72"
      }
    ], 
    "name": "Comparison of basic fibroblast growth factor levels in clone A human colon cancer cells in vitro with levels in xenografted tumours", 
    "pagination": "10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9c902afbb2ef61f86e67e892a50bfa8ac11b146b353e62d1b02177b7df411f18"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7599036"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1995.269"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032864627"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1995.269", 
      "https://app.dimensions.ai/details/publication/pub.1032864627"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54003_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc1995269"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1995.269'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1995.269'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1995.269'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1995.269'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      84 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1995.269 schema:about N1bacd08d12bc4e82b5c3689d15eb6a7d
2 N28a68d2e60c043bb800c718a2898a9a6
3 N38da26d0bb6c4f789ba3f3e6236d3dfa
4 N4beb0acb6fbf4654b655652df06b8177
5 N509eebd4bdc742b08e4f670b6183780c
6 N7e0740153faa44b8914d51d9a51a0e8f
7 N81543c41d1fc446588d8e0fefb69c6c0
8 N9bd9cb429d7042a5b99fc76a1480f76a
9 Na0c1000bd16142d2804a055877b2bd3f
10 Na81ce514fb1441d492ede96d3755d7a6
11 Nc5ec52f0cd27499697a47a6bb06596aa
12 Ne3bd6deb19db4883a2e6e1a537f908a8
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N29d7f8eb9be247d68c73e29ea969b667
16 schema:citation sg:pub.10.1007/bf02460621
17 sg:pub.10.1007/bf02460696
18 sg:pub.10.1038/359843a0
19 sg:pub.10.1038/bjc.1977.89
20 sg:pub.10.1038/bjc.1981.154
21 sg:pub.10.1038/bjc.1992.268
22 sg:pub.10.1038/bjc.1993.418
23 https://app.dimensions.ai/details/publication/pub.1077833245
24 https://app.dimensions.ai/details/publication/pub.1079701261
25 https://app.dimensions.ai/details/publication/pub.1079959674
26 https://app.dimensions.ai/details/publication/pub.1081866744
27 https://app.dimensions.ai/details/publication/pub.1082708503
28 https://app.dimensions.ai/details/publication/pub.1082716798
29 https://app.dimensions.ai/details/publication/pub.1082720100
30 https://app.dimensions.ai/details/publication/pub.1082775304
31 https://app.dimensions.ai/details/publication/pub.1082927653
32 https://doi.org/10.1002/ijc.2910440120
33 https://doi.org/10.1002/jcb.240450208
34 https://doi.org/10.1002/jcp.1041290220
35 https://doi.org/10.1016/0002-9343(81)90312-0
36 https://doi.org/10.1016/0006-291x(85)90614-x
37 https://doi.org/10.1016/0006-291x(92)92277-5
38 https://doi.org/10.1016/0006-2952(79)90647-6
39 https://doi.org/10.1016/0006-8993(91)90837-l
40 https://doi.org/10.1016/0167-8140(91)90341-d
41 https://doi.org/10.1016/0303-7207(92)90007-s
42 https://doi.org/10.1016/0360-3016(85)90038-0
43 https://doi.org/10.1093/cvr/27.7.1214
44 https://doi.org/10.1093/jnci/78.2.371
45 https://doi.org/10.1093/jnci/82.24.1890
46 https://doi.org/10.1093/jnci/85.2.121
47 https://doi.org/10.1093/jnci/85.3.241
48 https://doi.org/10.1093/jnci/86.10.742
49 https://doi.org/10.1093/jnci/86.5.356
50 https://doi.org/10.1111/j.1365-2184.1987.tb01356.x
51 https://doi.org/10.1111/j.1365-2184.1994.tb01387.x
52 https://doi.org/10.1111/j.1600-0676.1991.tb00529.x
53 https://doi.org/10.1126/science.3137658
54 https://doi.org/10.1163/156856293x00096
55 https://doi.org/10.1523/jneurosci.12-10-03828.1992
56 https://doi.org/10.3109/08977198809000242
57 https://doi.org/10.3109/08977199309010832
58 https://doi.org/10.3109/08977199309029135
59 schema:datePublished 1995-07
60 schema:datePublishedReg 1995-07-01
61 schema:description We measured levels of basic fibroblast growth factor (FGF-2) in human colon cancer cells (clone A) in vitro and in xenografted solid tumours using a commercial enzyme-linked immunoassay. In Vitro, levels in unfed plateau phase or exponentially growing cells were low, averaging respectively about 2 and 8 pg 10(-6) cells. However, when solid tumours (average volumes 787 mm3) were cut into halves and either enzymatically disaggregated to obtain a cellular fraction or extracted in toto, levels were much higher. In the cellular fraction, values averaged 110 pg 10(-6) cells, while in whole tumour extracts, average values were 24 pg mg-1 tumour tissue. These results indicate that growth factor levels in solid neoplasms may differ markedly from those predicted from in vitro measurements. We hypothesise that the apparent increase in FGF-2 levels in vivo results primarily from the presence of a significant fraction of host cells (in particular, macrophages, which may contain high levels of FGF-2) within xenografted clone A neoplasms.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N4135e37270d84defbd9fe286ad6602b1
66 N7e45cb7fc9e644628f1289a4fe4bd45e
67 sg:journal.1017082
68 schema:name Comparison of basic fibroblast growth factor levels in clone A human colon cancer cells in vitro with levels in xenografted tumours
69 schema:pagination 10
70 schema:productId N699bd496e2fe421488f9ce17da6cfa85
71 N96d4acedd3c140199e2a9648a5bed708
72 Nba11f59eeb7e43aaa7555e09c5deceb7
73 Nd683d36626ca4033944befdb194a5544
74 Nfb9aa874cf9744f8ac02c88cb7641eb8
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032864627
76 https://doi.org/10.1038/bjc.1995.269
77 schema:sdDatePublished 2019-04-11T12:14
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Ndcce9e113c7c48dab0003908a7bbe88a
80 schema:url https://www.nature.com/articles/bjc1995269
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N1a2bb42814c842aa959496d16745ebd0 schema:familyName Harris
85 schema:givenName B Z
86 rdf:type schema:Person
87 N1bacd08d12bc4e82b5c3689d15eb6a7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Molecular Sequence Data
89 rdf:type schema:DefinedTerm
90 N1eefc9d5ca1c43fdb5b95c68211c944f rdf:first N1a2bb42814c842aa959496d16745ebd0
91 rdf:rest N6086f523858b47b09cc9a63d08abc6b8
92 N28a68d2e60c043bb800c718a2898a9a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Colonic Neoplasms
94 rdf:type schema:DefinedTerm
95 N29d7f8eb9be247d68c73e29ea969b667 rdf:first Nbef26a0642f043cf93b41931bad66e73
96 rdf:rest Nc68ff84a8eb8450591ba1e882ad4f2b4
97 N38da26d0bb6c4f789ba3f3e6236d3dfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Male
99 rdf:type schema:DefinedTerm
100 N3c10b8a7815e49d2a2b67f88a47ca442 schema:familyName Karr
101 schema:givenName S M
102 rdf:type schema:Person
103 N4135e37270d84defbd9fe286ad6602b1 schema:issueNumber 1
104 rdf:type schema:PublicationIssue
105 N4beb0acb6fbf4654b655652df06b8177 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice
107 rdf:type schema:DefinedTerm
108 N509eebd4bdc742b08e4f670b6183780c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice, Nude
110 rdf:type schema:DefinedTerm
111 N6086f523858b47b09cc9a63d08abc6b8 rdf:first sg:person.01131470600.11
112 rdf:rest N88e7c57205a84840aece2fee2d1841b9
113 N699bd496e2fe421488f9ce17da6cfa85 schema:name nlm_unique_id
114 schema:value 0370635
115 rdf:type schema:PropertyValue
116 N7e0740153faa44b8914d51d9a51a0e8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Transplantation, Heterologous
118 rdf:type schema:DefinedTerm
119 N7e45cb7fc9e644628f1289a4fe4bd45e schema:volumeNumber 72
120 rdf:type schema:PublicationVolume
121 N81543c41d1fc446588d8e0fefb69c6c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Neoplasm Transplantation
123 rdf:type schema:DefinedTerm
124 N88e7c57205a84840aece2fee2d1841b9 rdf:first sg:person.0727651021.10
125 rdf:rest rdf:nil
126 N96d4acedd3c140199e2a9648a5bed708 schema:name dimensions_id
127 schema:value pub.1032864627
128 rdf:type schema:PropertyValue
129 N9bd9cb429d7042a5b99fc76a1480f76a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name RNA, Messenger
131 rdf:type schema:DefinedTerm
132 Na0c1000bd16142d2804a055877b2bd3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Fibroblast Growth Factor 2
134 rdf:type schema:DefinedTerm
135 Na81ce514fb1441d492ede96d3755d7a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Animals
137 rdf:type schema:DefinedTerm
138 Nba11f59eeb7e43aaa7555e09c5deceb7 schema:name doi
139 schema:value 10.1038/bjc.1995.269
140 rdf:type schema:PropertyValue
141 Nbef26a0642f043cf93b41931bad66e73 schema:affiliation https://www.grid.ac/institutes/grid.40263.33
142 schema:familyName McCarty
143 schema:givenName L P
144 rdf:type schema:Person
145 Nc5ec52f0cd27499697a47a6bb06596aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Base Sequence
147 rdf:type schema:DefinedTerm
148 Nc68ff84a8eb8450591ba1e882ad4f2b4 rdf:first N3c10b8a7815e49d2a2b67f88a47ca442
149 rdf:rest N1eefc9d5ca1c43fdb5b95c68211c944f
150 Nd683d36626ca4033944befdb194a5544 schema:name readcube_id
151 schema:value 9c902afbb2ef61f86e67e892a50bfa8ac11b146b353e62d1b02177b7df411f18
152 rdf:type schema:PropertyValue
153 Ndcce9e113c7c48dab0003908a7bbe88a schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 Ne3bd6deb19db4883a2e6e1a537f908a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 Nfb9aa874cf9744f8ac02c88cb7641eb8 schema:name pubmed_id
159 schema:value 7599036
160 rdf:type schema:PropertyValue
161 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
162 schema:name Biological Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
165 schema:name Biochemistry and Cell Biology
166 rdf:type schema:DefinedTerm
167 sg:grant.2470249 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.1995.269
168 rdf:type schema:MonetaryGrant
169 sg:journal.1017082 schema:issn 0007-0920
170 1532-1827
171 schema:name British Journal of Cancer
172 rdf:type schema:Periodical
173 sg:person.01131470600.11 schema:familyName Michelson
174 schema:givenName S G
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131470600.11
176 rdf:type schema:Person
177 sg:person.0727651021.10 schema:familyName Leith
178 schema:givenName J T
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727651021.10
180 rdf:type schema:Person
181 sg:pub.10.1007/bf02460621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048595657
182 https://doi.org/10.1007/bf02460621
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/bf02460696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009710397
185 https://doi.org/10.1007/bf02460696
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/359843a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028884048
188 https://doi.org/10.1038/359843a0
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/bjc.1977.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024189985
191 https://doi.org/10.1038/bjc.1977.89
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/bjc.1981.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001461538
194 https://doi.org/10.1038/bjc.1981.154
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/bjc.1992.268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012647208
197 https://doi.org/10.1038/bjc.1992.268
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/bjc.1993.418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011468953
200 https://doi.org/10.1038/bjc.1993.418
201 rdf:type schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1077833245 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1079701261 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1079959674 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1081866744 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1082708503 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1082716798 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1082720100 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1082775304 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1082927653 schema:CreativeWork
211 https://doi.org/10.1002/ijc.2910440120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039962719
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/jcb.240450208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001955515
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/jcp.1041290220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034497177
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0002-9343(81)90312-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042804098
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0006-291x(85)90614-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044897839
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0006-291x(92)92277-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007190977
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0006-2952(79)90647-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033567986
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0006-8993(91)90837-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1026657487
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0167-8140(91)90341-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1047280357
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/0303-7207(92)90007-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1049449778
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0360-3016(85)90038-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017805640
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/cvr/27.7.1214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059487860
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/jnci/78.2.371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079767308
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1093/jnci/82.24.1890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059816209
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/jnci/85.2.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818188
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1093/jnci/85.3.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818398
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1093/jnci/86.10.742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818613
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/jnci/86.5.356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819127
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1111/j.1365-2184.1987.tb01356.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032000232
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/j.1365-2184.1994.tb01387.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018249206
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1600-0676.1991.tb00529.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004525119
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1126/science.3137658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062593394
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1163/156856293x00096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038545503
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1523/jneurosci.12-10-03828.1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076202631
258 rdf:type schema:CreativeWork
259 https://doi.org/10.3109/08977198809000242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042995162
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3109/08977199309010832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006217565
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3109/08977199309029135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038842369
264 rdf:type schema:CreativeWork
265 https://www.grid.ac/institutes/grid.40263.33 schema:alternateName Brown University
266 schema:name Department of Radiation Medicine, Brown University School of Medicine, Providence, Rhode Island 02912, USA.
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...