Comparison of basic fibroblast growth factor levels in clone A human colon cancer cells in vitro with levels in xenografted ... View Full Text


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Article Info

DATE

1995-07

AUTHORS

L P McCarty, S M Karr, B Z Harris, S G Michelson, J T Leith

ABSTRACT

We measured levels of basic fibroblast growth factor (FGF-2) in human colon cancer cells (clone A) in vitro and in xenografted solid tumours using a commercial enzyme-linked immunoassay. In Vitro, levels in unfed plateau phase or exponentially growing cells were low, averaging respectively about 2 and 8 pg 10(-6) cells. However, when solid tumours (average volumes 787 mm3) were cut into halves and either enzymatically disaggregated to obtain a cellular fraction or extracted in toto, levels were much higher. In the cellular fraction, values averaged 110 pg 10(-6) cells, while in whole tumour extracts, average values were 24 pg mg-1 tumour tissue. These results indicate that growth factor levels in solid neoplasms may differ markedly from those predicted from in vitro measurements. We hypothesise that the apparent increase in FGF-2 levels in vivo results primarily from the presence of a significant fraction of host cells (in particular, macrophages, which may contain high levels of FGF-2) within xenografted clone A neoplasms. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1995.269

DOI

http://dx.doi.org/10.1038/bjc.1995.269

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7599036


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