Soluble c-erbB-2 fragment in serum correlates with disease stage and predicts for shortened survival in patients with early-stage and advanced ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-10

AUTHORS

H Kandl, L Seymour, W R Bezwoda

ABSTRACT

Seventy-nine patients with advanced breast cancer were tested for the presence, in serum, of a 110 kDa soluble, c-erbB-2 fragment. Thirty-nine patients were seropositive. There was no correlation between seropositivity and menopausal status, or with oestrogen status. In addition, no correlation could be found between tissue c-erbB-2 immunostaining for the external domain of the c-erbB-2 receptor and the presence of soluble c-erbB-2 in serum. The presence of serum soluble c-erbB-2, however, had a significant impact on survival of patients with advanced disease, suggesting that this test may become a useful independent prognostic indicator. More... »

PAGES

739

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1994.387

DOI

http://dx.doi.org/10.1038/bjc.1994.387

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021569604

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7522511


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