Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-10

AUTHORS

B Dix, P Robbins, S Carrello, A House, B Iacopetta

ABSTRACT

Immunocytochemistry (ICC) has been used routinely to stain for p53 overexpression in a range of human tumours. The underlying assumption has been that positive staining indicates a mutation in the p53 coding sequence. Recently, however, discordancy has been observed and the accuracy of ICC as a marker of p53 gene mutation has been questioned. In this study of 109 colorectal adenocarcinomas, we compared ICC staining with p53 gene mutations detected by single-strand conformation polymorphism (SSCP) analysis. Concordancy between the two techniques was found in 69% of tumours. ICC-positive/SSCP-negative cases accounted for 20% of tumours and ICC-negative/SSCP-positive cases for the remaining 11%. These results caution against the assumption that p53 protein overexpression is always associated with a gene mutation. Epigenetic phenomena may account for a significant proportion of ICC-positive tumours. More... »

PAGES

585-590

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1994.355

DOI

http://dx.doi.org/10.1038/bjc.1994.355

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028087104

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7917901


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