Epidermal growth factor receptor expression by human squamous cell carcinomas of the head and neck, cell lines and xenografts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-09

AUTHORS

P Stanton, S Richards, J Reeves, M Nikolic, K Edington, L Clark, G Robertson, D Souter, R Mitchell, FJ Hendler, T Cooke, EK Parkinson, BW Ozanne

ABSTRACT

Epidermal growth factor receptor (EGFR) overexpression has been associated frequently with squamous cell carcinomas (SCC) and SCC cell lines. In most cases the level of EGFR on the tumours from which the cell lines were derived has not been determined, nor have EGFR levels been determined for xenograft tumours from the cell lines. In this study we determined EGFR expression on a new series of head and neck SCC (SCCHN)-derived cell lines, which were obtained from tumours representing a spectrum of malignant progression, and two cell strains derived from erythroplakia premalignant lesions. The level of EGFR on cell lines was determined by [125I]EGF competitive binding assays. EGFR levels on some of the original tumours and xenografts of the cell lines were determined on cryosections by a competitive binding assay based on [125I]EGFR1, an EGFR-specific monoclonal antibody. EGFR expression on the tumour cryosections was compared with expression on cryosections of skin and buccal mucosa. Eight of the ten tumour cell lines had elevated EGFR. Two of the tumour-derived cell lines and the two erythroplakia-derived cell strains expressed EGFR at levels similar to that detected on normal keratinocytes in tissue culture. Only two of the tumours overexpressed EGFR when compared with normal tissue. The other tumours had levels similar to that detected on the basal layers of skin or buccal mucosa. The xenografts expressed EGFR, as did the original tumours, even though they were derived from cell lines that displayed significant overexpression of EGFR. This study suggests that most tumours have a latent potential to overexpress EGFR which is realised in tissue culture. More... »

PAGES

427-433

References to SciGraph publications

  • 1994-01. Epidermal growth factor and transforming growth factor α characteristics of human oral carcinoma cell lines in BRITISH JOURNAL OF CANCER
  • 1977-02. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes in NATURE
  • 1993-06. Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines in BRITISH JOURNAL OF CANCER
  • 1993-09. The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck in BRITISH JOURNAL OF CANCER
  • 1984-05. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells in NATURE
  • 1981-06. Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck in BRITISH JOURNAL OF CANCER
  • 1989-04. Gene amplification and overexpression of EGF receptor in squamous cell carcinomas of the head and neck in BRITISH JOURNAL OF CANCER
  • 1986-02. Increased EGF receptors on human squamous carcinoma cell lines in BRITISH JOURNAL OF CANCER
  • 1974-11. Preparation of human placental villous surface membrane in NATURE
  • 1985-02. Autocrine growth factors and cancer in NATURE
  • 1993-02. The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468 in BRITISH JOURNAL OF CANCER
  • 1993-02. Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.1994.322

    DOI

    http://dx.doi.org/10.1038/bjc.1994.322

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035789167

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8080726


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