Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-03

AUTHORS

N Harbeck, M Untch, L Pache, W Eiermann

ABSTRACT

We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tumour cell-positive patients have since relapsed, but only 9/62 (15%) tumour cell-negative patients. The median interval between tumour cell detection and relapse was 11.4 months. No statistically significant correlation existed between tumour cell presence and 'established' prognostic factors. However, relapse-free survival was significantly shorter in tumour cell-positive patients. Multivariate analysis showed tumour cell presence as a strong, significant prognostic factor for relapse-free as well as overall survival. We conclude that screening for tumour cells in bone marrow of primary breast cancer patients identifies high-risk patients for early relapse. In particular, patients with node-negative tumours who have tumour cells in their bone marrow may require subsequent systemic therapy. More... »

PAGES

566

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1994.103

DOI

http://dx.doi.org/10.1038/bjc.1994.103

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008369910

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7510120


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