Prognostic impact of EGF-receptor in papillary thyroid carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-10

AUTHORS

L A Akslen, A O Myking, H Salvesen, J E Varhaug

ABSTRACT

In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas. More... »

PAGES

808

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1993.432

DOI

http://dx.doi.org/10.1038/bjc.1993.432

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026081465

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8398712


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