Prognostic significance of c-erbB-2 expression in node negative breast cancer. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-03

AUTHORS

S. Bianchi, M. Paglierani, G. Zampi, G. Cardona, L. Cataliotti, R. Bonardi, S. Ciatto

ABSTRACT

The prognostic value of c-erbB-2 oncogene expression was studied retrospectively in a consecutive series of 230 node negative breast cancers, followed-up for at least 7 years after primary treatment. The expression of c-erbB-2 oncoprotein was determined on formalin-fixed paraffin-embedded tissue, using a monoclonal anti-c-erbB-2 antibody by the avidin-biotin immunoperoxidase method. Positive immunostaining was observed in 20.9% of cases, whereas strong diffuse positivity was recorded only in 8.7% of cases. C-erbB-2 gene product showed no association to T category or nuclear grade. A significant association of c-erbB-2 expression to prognosis was observed only for cases showing a strong diffuse immunostaining, but such an association was no longer statistically significant at multivariate analysis adjusting for other prognostic factors such as T category and nuclear grading. C-erbB-2 expression is of no value to predict the clinical course of node negative patients in the current practice. More... »

PAGES

625-629

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1993.114

DOI

http://dx.doi.org/10.1038/bjc.1993.114

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047972793

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8094977


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