Adjuvant Tamoxifen for male breast cancer (MBC) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-02

AUTHORS

G Ribeiro, R Swindell

ABSTRACT

A study was started in 1976 whereby patients with Stage II and operable Stage III MBC were given adjuvant Tamoxifen for 1 year, increasing to 2 years from 1988. All patients had axillary nodal involvement. Primary treatment consisted of a radical mastectomy or simple mastectomy with radiotherapy. The rarity of the disease precluded a randomised trial. Thirty-nine patients are available for analysis at a median follow-up of 49 months. The actuarial survival of the Tamoxifen treated patients is 61% (range 42-80%) at 5 years compared to 44% (range 35-53%) for historical controls (P = 0.006). Disease-free survival was 56% (37-75%) vs 28% (17-33%) at 5 years (P = 0.005). There were no serious side-effects recorded. The conclusion from this, the first reported series on adjuvant Tamoxifen therapy for MBC, is that significant improvement in disease-free survival can be achieved with minimal upset to the patients. Recruitment to the study continues. More... »

PAGES

bjc199250

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1992.50

DOI

http://dx.doi.org/10.1038/bjc.1992.50

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018874103

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1739625


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