Biological activities of phthalocyanines. XIV. Effect of hydrophobic phthalimidomethyl groups on the in vivo phototoxicity and mechanism of photodynamic action ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-06

AUTHORS

R W Boyle, B Paquette, J E van Lier

ABSTRACT

Aluminium phthalocyanines substituted to different degrees with hydrophilic sulphonic acid and hydrophobic phthalimidomethyl groups were investigated in vivo as new agents for the photodynamic therapy of malignant tumours. Parameters studied included the photodynamic action on EMT-6 mammary tumours in BALB/c mice, the therapeutic window and the potential for direct cell killing, assayed via an in vivo/in vitro test. Although the efficiency of photoinactivation of the EMT-6 tumour increases by a factor of ten with reduction of the number of sulphonic acid groups from four to two, no further effect was seen with the addition of the hydrophobic phthalimidomethyl groups. Addition of the latter groups however increased the potential for direct cell killing by a factor of two and expanded the therapeutic window by a factor of four, thus improving the usefulness of the dye as a photosensitiser for the photodynamic therapy of cancer. More... »

PAGES

bjc1992174

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1992.174

DOI

http://dx.doi.org/10.1038/bjc.1992.174

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022824101

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1616852


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