Comparison of two oestrogen receptor assays in the prediction of the clinical course of patients with advanced breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-05

AUTHORS

J F Robertson, K Bates, D Pearson, R W Blamey, R I Nicholson

ABSTRACT

We have examined two new oestrogen receptor (ER) assays--an enzyme immunoassay (EIA) and an immunocytochemical assay (ICA) in a large series of primary breast tumours to compare their potential as predictors of (1) response to endocrine therapy and (2) survival in patients developing advanced breast cancer. Response to endocrine therapy was categorised at 6 months (UICC criteria). ER-ICA appears the better predictor of response to endocrine therapy than ER-EIA. Combining ICA and EIA results did not improve the prediction of response. With both assays patients with ER positive tumours survived longer from the time of diagnosis of advanced disease than those with ER negative tumours. The predictive power of these assay for progression of disease appears slightly better for the ER-ICA. More... »

PAGES

727

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1992.153

DOI

http://dx.doi.org/10.1038/bjc.1992.153

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022813323

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1534019


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