A chelating derivative of α-melanocyte stimulating hormone as a potential imaging agent for malignant melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-12

AUTHORS

D R Bard, C G Knight, D P Page-Thomas

ABSTRACT

A chelating derivative of alpha-melanocyte stimulating hormone (MSH) has been synthesised, in which two molecules of the hormone are cross-linked by diethylenetriamine pentaacetic acid (DTPA). This compound, bisMSH-DTPA, was equipotent with MSH in an in vitro tyrosinase assay with Cloudman S91 melanoma cells. When DBA/2 mice bearing the same tumour were injected with bisMSH-DTPA labelled with the gamma-emitting isotope indium-111 (111In), the radioactivity became rapidly associated with the melanoma tissue. By 24 h post-injection, radioactivity in tumour tissue was significantly higher (P less than 0.001) than in spleen, lung, brain, eye and skin. Uptake of radioactivity by the tumours was inhibited by a 200-fold molar excess of MSH, whereas uptake by liver, kidney, spleen, lung, brain, eye and skin was unaffected. We conclude that bisMSH-DTPA may offer an alternative to antibody targeting in the imaging of malignant melanoma. More... »

PAGES

919

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1990.409

DOI

http://dx.doi.org/10.1038/bjc.1990.409

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045259212

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2257220


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