Gene expression in oestrogen-dependent human breast cancer xenograft tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-07

AUTHORS

A M Thompson, C M Steel, M E Foster, D Kerr, D Paterson, D Deane, R A Hawkins, D C Carter, H J Evans

ABSTRACT

Xenograft tumours from an oestrogen-dependent human breast cancer cell line MCF-7 have been established and characterised in thymectomised, irradiated female CBA strain mice. There was evidence for selection in xenografts of a subpopulation of MCF-7 cells with an altered pattern of gene expression as measured by mRNA levels compared with the original cells in vitro. Tumorigenicity increased significantly on repeated animal passage but oestrogen dependence was retained. Following injection of the mice with oestrogen, mitosis was induced in the tumour cells with associated increases in thymidine uptake and percentage of cells in S-phase. In accord with these changes, c-myc and p53 expression were increased and TGF-beta was suppressed. Thereafter the expression of the c-myc and p53 genes fell whilst that of the TGF-beta gene was induced as the oestrogenic-stimulus declined. The oestrogen-regulated mRNA pS2 showed a biphasic response to oestrogen and levels declined as the serum oestrogen fell to undetectable levels. This xenograft system demonstrates that changes in transcription of oncogenes, growth factor and oestrogen-regulated genes can be detected in vivo in response to oestrogen. It thus provides an in vivo model for studies of the biochemical and molecular basis for therapeutic manipulation of hormone-sensitive human breast cancer. More... »

PAGES

78

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1990.233

DOI

http://dx.doi.org/10.1038/bjc.1990.233

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036300011

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2390487


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Northern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Probes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred CBA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Hormone-Dependent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Edinburgh Royal Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.418716.d", 
          "name": [
            "Department of Surgery, Royal Infirmary of Edinburgh, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "A M", 
        "id": "sg:person.015454463352.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015454463352.67"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Steel", 
        "givenName": "C M", 
        "id": "sg:person.01066500762.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066500762.94"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Foster", 
        "givenName": "M E", 
        "id": "sg:person.01015173101.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015173101.83"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kerr", 
        "givenName": "D", 
        "id": "sg:person.01176000214.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176000214.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Paterson", 
        "givenName": "D", 
        "type": "Person"
      }, 
      {
        "familyName": "Deane", 
        "givenName": "D", 
        "id": "sg:person.01060414101.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060414101.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hawkins", 
        "givenName": "R A", 
        "id": "sg:person.01305716406.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305716406.49"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Carter", 
        "givenName": "D C", 
        "id": "sg:person.01011065312.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011065312.15"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Evans", 
        "givenName": "H J", 
        "id": "sg:person.0106540554.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106540554.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01807279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000250378", 
          "https://doi.org/10.1007/bf01807279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000250378", 
          "https://doi.org/10.1007/bf01807279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00915003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000986849", 
          "https://doi.org/10.1007/bf00915003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309418a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009921132", 
          "https://doi.org/10.1038/309418a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1980.tb06030.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011336402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013575831", 
          "https://doi.org/10.1038/bjc.1988.267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013575831", 
          "https://doi.org/10.1038/bjc.1988.267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(88)90113-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014335580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(88)90113-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014335580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/304596a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014984097", 
          "https://doi.org/10.1038/304596a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.990060604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019364365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.990060604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019364365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/jme.0.0020131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021593837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910340406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030351515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01806264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031004389", 
          "https://doi.org/10.1007/bf01806264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01806264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031004389", 
          "https://doi.org/10.1007/bf01806264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.20.6344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032214943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(75)80083-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033296365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/002367785780942561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033307736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/002367785780942561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033307736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.7.1991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034589758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2964(79)90139-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035963073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.6.5.1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036586205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/316701a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036618381", 
          "https://doi.org/10.1038/316701a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.82.19.6497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037809345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.82.23.7889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037873642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1978.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040345971", 
          "https://doi.org/10.1038/bjc.1978.30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1978.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040345971", 
          "https://doi.org/10.1038/bjc.1978.30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.296.6637.1621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040565979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711480405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040694966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711480405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040694966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(84)90550-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041222541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.7.7.2597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042233582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-7207(87)90049-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046916420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-7207(87)90049-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046916420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049441914", 
          "https://doi.org/10.1007/bf01807562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049441914", 
          "https://doi.org/10.1007/bf01807562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/10.24.7895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059931641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend-2-11-1064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064330165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend-2-12-1157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064330181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078808062", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079456255", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079604129", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079767004", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079891825", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079891834", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080058124", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1985.tb03768.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080078451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/51.5.1409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080295272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/53.3.661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080329326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081647539", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/67.1.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081652072"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-07", 
    "datePublishedReg": "1990-07-01", 
    "description": "Xenograft tumours from an oestrogen-dependent human breast cancer cell line MCF-7 have been established and characterised in thymectomised, irradiated female CBA strain mice. There was evidence for selection in xenografts of a subpopulation of MCF-7 cells with an altered pattern of gene expression as measured by mRNA levels compared with the original cells in vitro. Tumorigenicity increased significantly on repeated animal passage but oestrogen dependence was retained. Following injection of the mice with oestrogen, mitosis was induced in the tumour cells with associated increases in thymidine uptake and percentage of cells in S-phase. In accord with these changes, c-myc and p53 expression were increased and TGF-beta was suppressed. Thereafter the expression of the c-myc and p53 genes fell whilst that of the TGF-beta gene was induced as the oestrogenic-stimulus declined. The oestrogen-regulated mRNA pS2 showed a biphasic response to oestrogen and levels declined as the serum oestrogen fell to undetectable levels. This xenograft system demonstrates that changes in transcription of oncogenes, growth factor and oestrogen-regulated genes can be detected in vivo in response to oestrogen. It thus provides an in vivo model for studies of the biochemical and molecular basis for therapeutic manipulation of hormone-sensitive human breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1990.233", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "62"
      }
    ], 
    "name": "Gene expression in oestrogen-dependent human breast cancer xenograft tumours", 
    "pagination": "78", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "aceb2a8fd146091a1737e13a7df7d668b91a878caed770a7a8f7b9ec1e9359ff"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2390487"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1990.233"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036300011"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1990.233", 
      "https://app.dimensions.ai/details/publication/pub.1036300011"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29216_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc1990233"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1990.233'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1990.233'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1990.233'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1990.233'


 

This table displays all metadata directly associated to this object as RDF triples.

315 TRIPLES      21 PREDICATES      89 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1990.233 schema:about N02c7d1eb7df84fcf83fc3f19c15ddf54
2 N170eda0ba1564443afff4b19b5ab8ebe
3 N24966eb6fe6244b4af37e32a9321fdf4
4 N52f0d786d538438c9168019c154516fe
5 N5f8ba9e73eef42fdb40a60705bcef215
6 N6a1b421aa2e3408eaabe4fbe87f1418c
7 N718b173a74794a3f82a3a6748c2a7c75
8 N846de6d424b14c7c8a74169fb566e119
9 N90e2d2af1b0446508a7ed229c2d3f1cd
10 N98a84f54084a42b8b57336f34a9d4710
11 N998235a03ddf4a388e0b311ca49204a0
12 Nbb4a6f1695924f61bb0034a2b6f63239
13 Nbdae6a85fde94ecab9e2b5f54521c538
14 Nc5ca0832d39f429aa2afb9f49c555487
15 Nc743881ea15b440f92a35e4d8200022d
16 Ncb0316693750461cbc5200e8a87addfa
17 Ne20854213fb04c149de82d87e1496b8b
18 Ne222d5d9337e4e918db018e7c435b407
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Nf6f3227964d74d96919c78cc90a90a83
22 schema:citation sg:pub.10.1007/bf00915003
23 sg:pub.10.1007/bf01806264
24 sg:pub.10.1007/bf01807279
25 sg:pub.10.1007/bf01807562
26 sg:pub.10.1038/304596a0
27 sg:pub.10.1038/309418a0
28 sg:pub.10.1038/316701a0
29 sg:pub.10.1038/bjc.1978.30
30 sg:pub.10.1038/bjc.1988.267
31 https://app.dimensions.ai/details/publication/pub.1078808062
32 https://app.dimensions.ai/details/publication/pub.1079456255
33 https://app.dimensions.ai/details/publication/pub.1079604129
34 https://app.dimensions.ai/details/publication/pub.1079767004
35 https://app.dimensions.ai/details/publication/pub.1079891825
36 https://app.dimensions.ai/details/publication/pub.1079891834
37 https://app.dimensions.ai/details/publication/pub.1080058124
38 https://app.dimensions.ai/details/publication/pub.1081647539
39 https://doi.org/10.1002/cyto.990060604
40 https://doi.org/10.1002/ijc.2910340406
41 https://doi.org/10.1002/j.1460-2075.1985.tb03768.x
42 https://doi.org/10.1002/path.1711480405
43 https://doi.org/10.1016/0014-2964(79)90139-7
44 https://doi.org/10.1016/0022-4731(88)90113-6
45 https://doi.org/10.1016/0092-8674(84)90550-6
46 https://doi.org/10.1016/0303-7207(87)90049-9
47 https://doi.org/10.1016/s0022-2836(75)80083-0
48 https://doi.org/10.1073/pnas.81.20.6344
49 https://doi.org/10.1073/pnas.81.7.1991
50 https://doi.org/10.1073/pnas.82.19.6497
51 https://doi.org/10.1073/pnas.82.23.7889
52 https://doi.org/10.1093/jnci/51.5.1409
53 https://doi.org/10.1093/jnci/53.3.661
54 https://doi.org/10.1093/jnci/67.1.51
55 https://doi.org/10.1093/nar/10.24.7895
56 https://doi.org/10.1111/j.1432-1033.1980.tb06030.x
57 https://doi.org/10.1128/mcb.6.5.1379
58 https://doi.org/10.1128/mcb.7.7.2597
59 https://doi.org/10.1136/bmj.296.6637.1621
60 https://doi.org/10.1210/mend-2-11-1064
61 https://doi.org/10.1210/mend-2-12-1157
62 https://doi.org/10.1258/002367785780942561
63 https://doi.org/10.1677/jme.0.0020131
64 schema:datePublished 1990-07
65 schema:datePublishedReg 1990-07-01
66 schema:description Xenograft tumours from an oestrogen-dependent human breast cancer cell line MCF-7 have been established and characterised in thymectomised, irradiated female CBA strain mice. There was evidence for selection in xenografts of a subpopulation of MCF-7 cells with an altered pattern of gene expression as measured by mRNA levels compared with the original cells in vitro. Tumorigenicity increased significantly on repeated animal passage but oestrogen dependence was retained. Following injection of the mice with oestrogen, mitosis was induced in the tumour cells with associated increases in thymidine uptake and percentage of cells in S-phase. In accord with these changes, c-myc and p53 expression were increased and TGF-beta was suppressed. Thereafter the expression of the c-myc and p53 genes fell whilst that of the TGF-beta gene was induced as the oestrogenic-stimulus declined. The oestrogen-regulated mRNA pS2 showed a biphasic response to oestrogen and levels declined as the serum oestrogen fell to undetectable levels. This xenograft system demonstrates that changes in transcription of oncogenes, growth factor and oestrogen-regulated genes can be detected in vivo in response to oestrogen. It thus provides an in vivo model for studies of the biochemical and molecular basis for therapeutic manipulation of hormone-sensitive human breast cancer.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N1869b0c0c8734264a812e90205b331e4
71 Na4b5bf0cf11c4931b6e5e7f4114b3120
72 sg:journal.1017082
73 schema:name Gene expression in oestrogen-dependent human breast cancer xenograft tumours
74 schema:pagination 78
75 schema:productId N0795543f886a47e39fcafd4000256f27
76 N07ec2d28ff234e7ebc950a354ca2ff8d
77 N264534bd03d442e4b275eb4018f5f1c0
78 Neb62d5838bd0467b85daaa5a766b943a
79 Nf551184e672f41baa0dd32212d77209b
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036300011
81 https://doi.org/10.1038/bjc.1990.233
82 schema:sdDatePublished 2019-04-11T11:56
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N5c6bfc9028994777adc0495bc315c702
85 schema:url https://www.nature.com/articles/bjc1990233
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N02c7d1eb7df84fcf83fc3f19c15ddf54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mice, Inbred CBA
91 rdf:type schema:DefinedTerm
92 N0795543f886a47e39fcafd4000256f27 schema:name dimensions_id
93 schema:value pub.1036300011
94 rdf:type schema:PropertyValue
95 N07ec2d28ff234e7ebc950a354ca2ff8d schema:name pubmed_id
96 schema:value 2390487
97 rdf:type schema:PropertyValue
98 N170eda0ba1564443afff4b19b5ab8ebe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Estrogens
100 rdf:type schema:DefinedTerm
101 N1869b0c0c8734264a812e90205b331e4 schema:volumeNumber 62
102 rdf:type schema:PublicationVolume
103 N24966eb6fe6244b4af37e32a9321fdf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Receptors, Estrogen
105 rdf:type schema:DefinedTerm
106 N264534bd03d442e4b275eb4018f5f1c0 schema:name readcube_id
107 schema:value aceb2a8fd146091a1737e13a7df7d668b91a878caed770a7a8f7b9ec1e9359ff
108 rdf:type schema:PropertyValue
109 N289ae79e8e9a45e7b7ccb6b904e9d5d6 rdf:first sg:person.01066500762.94
110 rdf:rest Nb68f89de216846d6b144bd65182f79cb
111 N3b00f2d50b034ae296b5645e229a4d40 rdf:first sg:person.01305716406.49
112 rdf:rest Nf3aa2f3f62174194aee2ef9f37753e88
113 N52f0d786d538438c9168019c154516fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Breast Neoplasms
115 rdf:type schema:DefinedTerm
116 N5c6bfc9028994777adc0495bc315c702 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N5f8ba9e73eef42fdb40a60705bcef215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name DNA Probes
120 rdf:type schema:DefinedTerm
121 N61de9cb09ffb429fae80c10202f4b807 schema:familyName Paterson
122 schema:givenName D
123 rdf:type schema:Person
124 N6a1b421aa2e3408eaabe4fbe87f1418c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Neoplasms, Hormone-Dependent
126 rdf:type schema:DefinedTerm
127 N6dafc2f80a724584bd4866f115cfa163 rdf:first sg:person.01060414101.21
128 rdf:rest N3b00f2d50b034ae296b5645e229a4d40
129 N7064c7d3c79645a9a0bf129526de53f0 rdf:first sg:person.0106540554.34
130 rdf:rest rdf:nil
131 N718b173a74794a3f82a3a6748c2a7c75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Blotting, Northern
133 rdf:type schema:DefinedTerm
134 N846de6d424b14c7c8a74169fb566e119 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Gene Expression Regulation, Neoplastic
136 rdf:type schema:DefinedTerm
137 N90e2d2af1b0446508a7ed229c2d3f1cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Transplantation, Heterologous
139 rdf:type schema:DefinedTerm
140 N935bc22b4e4c4b2f936bb3406ec41ddf rdf:first N61de9cb09ffb429fae80c10202f4b807
141 rdf:rest N6dafc2f80a724584bd4866f115cfa163
142 N98a84f54084a42b8b57336f34a9d4710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Rats
144 rdf:type schema:DefinedTerm
145 N998235a03ddf4a388e0b311ca49204a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name DNA
147 rdf:type schema:DefinedTerm
148 Na4b5bf0cf11c4931b6e5e7f4114b3120 schema:issueNumber 1
149 rdf:type schema:PublicationIssue
150 Nb68f89de216846d6b144bd65182f79cb rdf:first sg:person.01015173101.83
151 rdf:rest Nc854f80e0d1e46d4834dae066562874b
152 Nbb4a6f1695924f61bb0034a2b6f63239 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cell Division
154 rdf:type schema:DefinedTerm
155 Nbdae6a85fde94ecab9e2b5f54521c538 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Neoplasm Transplantation
157 rdf:type schema:DefinedTerm
158 Nc5ca0832d39f429aa2afb9f49c555487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Female
160 rdf:type schema:DefinedTerm
161 Nc743881ea15b440f92a35e4d8200022d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Nucleic Acid Hybridization
163 rdf:type schema:DefinedTerm
164 Nc854f80e0d1e46d4834dae066562874b rdf:first sg:person.01176000214.25
165 rdf:rest N935bc22b4e4c4b2f936bb3406ec41ddf
166 Ncb0316693750461cbc5200e8a87addfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name RNA, Messenger
168 rdf:type schema:DefinedTerm
169 Ne20854213fb04c149de82d87e1496b8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Animals
171 rdf:type schema:DefinedTerm
172 Ne222d5d9337e4e918db018e7c435b407 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Mice
174 rdf:type schema:DefinedTerm
175 Neb62d5838bd0467b85daaa5a766b943a schema:name nlm_unique_id
176 schema:value 0370635
177 rdf:type schema:PropertyValue
178 Nf3aa2f3f62174194aee2ef9f37753e88 rdf:first sg:person.01011065312.15
179 rdf:rest N7064c7d3c79645a9a0bf129526de53f0
180 Nf551184e672f41baa0dd32212d77209b schema:name doi
181 schema:value 10.1038/bjc.1990.233
182 rdf:type schema:PropertyValue
183 Nf6f3227964d74d96919c78cc90a90a83 rdf:first sg:person.015454463352.67
184 rdf:rest N289ae79e8e9a45e7b7ccb6b904e9d5d6
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
189 schema:name Oncology and Carcinogenesis
190 rdf:type schema:DefinedTerm
191 sg:journal.1017082 schema:issn 0007-0920
192 1532-1827
193 schema:name British Journal of Cancer
194 rdf:type schema:Periodical
195 sg:person.01011065312.15 schema:familyName Carter
196 schema:givenName D C
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011065312.15
198 rdf:type schema:Person
199 sg:person.01015173101.83 schema:familyName Foster
200 schema:givenName M E
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015173101.83
202 rdf:type schema:Person
203 sg:person.01060414101.21 schema:familyName Deane
204 schema:givenName D
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060414101.21
206 rdf:type schema:Person
207 sg:person.0106540554.34 schema:familyName Evans
208 schema:givenName H J
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106540554.34
210 rdf:type schema:Person
211 sg:person.01066500762.94 schema:familyName Steel
212 schema:givenName C M
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066500762.94
214 rdf:type schema:Person
215 sg:person.01176000214.25 schema:familyName Kerr
216 schema:givenName D
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176000214.25
218 rdf:type schema:Person
219 sg:person.01305716406.49 schema:familyName Hawkins
220 schema:givenName R A
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305716406.49
222 rdf:type schema:Person
223 sg:person.015454463352.67 schema:affiliation https://www.grid.ac/institutes/grid.418716.d
224 schema:familyName Thompson
225 schema:givenName A M
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015454463352.67
227 rdf:type schema:Person
228 sg:pub.10.1007/bf00915003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000986849
229 https://doi.org/10.1007/bf00915003
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/bf01806264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031004389
232 https://doi.org/10.1007/bf01806264
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/bf01807279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000250378
235 https://doi.org/10.1007/bf01807279
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/bf01807562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049441914
238 https://doi.org/10.1007/bf01807562
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/304596a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014984097
241 https://doi.org/10.1038/304596a0
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/309418a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009921132
244 https://doi.org/10.1038/309418a0
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/316701a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036618381
247 https://doi.org/10.1038/316701a0
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/bjc.1978.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040345971
250 https://doi.org/10.1038/bjc.1978.30
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/bjc.1988.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013575831
253 https://doi.org/10.1038/bjc.1988.267
254 rdf:type schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1078808062 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1079456255 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1079604129 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1079767004 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1079891825 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1079891834 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1080058124 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1081647539 schema:CreativeWork
263 https://doi.org/10.1002/cyto.990060604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019364365
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/ijc.2910340406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030351515
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/j.1460-2075.1985.tb03768.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1080078451
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/path.1711480405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040694966
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0014-2964(79)90139-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035963073
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/0022-4731(88)90113-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014335580
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/0092-8674(84)90550-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041222541
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/0303-7207(87)90049-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046916420
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0022-2836(75)80083-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033296365
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1073/pnas.81.20.6344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032214943
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.81.7.1991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034589758
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.82.19.6497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037809345
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.82.23.7889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037873642
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1093/jnci/51.5.1409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080295272
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1093/jnci/53.3.661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080329326
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1093/jnci/67.1.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081652072
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1093/nar/10.24.7895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059931641
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1432-1033.1980.tb06030.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011336402
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1128/mcb.6.5.1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036586205
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1128/mcb.7.7.2597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042233582
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1136/bmj.296.6637.1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565979
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1210/mend-2-11-1064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064330165
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1210/mend-2-12-1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064330181
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1258/002367785780942561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033307736
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1677/jme.0.0020131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021593837
312 rdf:type schema:CreativeWork
313 https://www.grid.ac/institutes/grid.418716.d schema:alternateName Edinburgh Royal Infirmary
314 schema:name Department of Surgery, Royal Infirmary of Edinburgh, UK.
315 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...