Ki67 immunostaining in primary breast cancer: pathological and clinical associations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1989-06

AUTHORS

N Bouzubar, K J Walker, K Griffiths, I O Ellis, C W Elston, J F Robertson, R W Blamey, R I Nicholson

ABSTRACT

Ki67 immunostaining has been performed on 136 primary breast cancers and related to various clinical and pathological features of the disease. Staining was most frequently seen in poorly differentiated tumours showing high rates of mitotic activity, but was independent of tumour size, lymph-node status and ER expression. A high level of Ki67 immunostaining was often associated with early recurrence of breast cancer after mastectomy. These data are consistent with the concept of the Ki67 antibody detecting an antigen that is closely related to cell proliferation and thus provides a clinically useful marker for this important characteristic of the tumour. More... »

PAGES

bjc1989200

References to SciGraph publications

  • 1982-03. A prognostic index in primary breast cancer in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.1989.200

    DOI

    http://dx.doi.org/10.1038/bjc.1989.200

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040502985

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2472168


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