Effects of vitamin A and E supplementation to diets containing two different fat levels on methylnitrosourea-induced mammary carcinogenesis in female ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1987-12

AUTHORS

M Beth, MR Berger, M Aksoy, D Schmähl

ABSTRACT

The aim of this study was to elucidate the effects of dietary vitamin A and E supplementation on tumorigenesis in correlation to the fat content of the respective diet in an animal model. One hundred and twenty female SD rats were initiated intravenously with 25 mg MNU kg-1 on day 50 of life. For a period of 6 months, beginning after the day of initiation, all animals received a semisynthetic diet containing 25% or 45% of the energy as fat, supplemented either with a 10-fold higher amount of naturally occurring vitamins A and E than in rat standard diets or, with a normal level of these vitamins. The experiment showed: (1) Vitamin A and E supplementation showed no significant chemopreventive effect against mammary tumour development. (2) This result was independent from the supplied fat level of the respective diet. (3) The fat content per se did not significantly influence mammary tumorigenesis. More... »

PAGES

445-449

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1987.221

DOI

http://dx.doi.org/10.1038/bjc.1987.221

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019905374

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3689661


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Fats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methylnitrosourea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vitamin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vitamin E", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beth", 
        "givenName": "M", 
        "id": "sg:person.01172047773.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172047773.27"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Berger", 
        "givenName": "MR", 
        "id": "sg:person.01256203524.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Aksoy", 
        "givenName": "M", 
        "id": "sg:person.01017036027.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017036027.48"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Schm\u00e4hl", 
        "givenName": "D", 
        "id": "sg:person.0105462430.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105462430.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01900187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015935443", 
          "https://doi.org/10.1007/bf01900187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/267620a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035223096", 
          "https://doi.org/10.1038/267620a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1987-12", 
    "datePublishedReg": "1987-12-01", 
    "description": "The aim of this study was to elucidate the effects of dietary vitamin A and E supplementation on tumorigenesis in correlation to the fat content of the respective diet in an animal model. One hundred and twenty female SD rats were initiated intravenously with 25 mg MNU kg-1 on day 50 of life. For a period of 6 months, beginning after the day of initiation, all animals received a semisynthetic diet containing 25% or 45% of the energy as fat, supplemented either with a 10-fold higher amount of naturally occurring vitamins A and E than in rat standard diets or, with a normal level of these vitamins. The experiment showed: (1) Vitamin A and E supplementation showed no significant chemopreventive effect against mammary tumour development. (2) This result was independent from the supplied fat level of the respective diet. (3) The fat content per se did not significantly influence mammary tumorigenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/bjc.1987.221", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "keywords": [
      "E supplementation", 
      "vitamin A", 
      "respective diets", 
      "female SD rats", 
      "mammary tumor development", 
      "dietary vitamin A", 
      "days of initiation", 
      "significant chemopreventive effect", 
      "SD rats", 
      "mammary carcinogenesis", 
      "chemopreventive effects", 
      "mammary tumorigenesis", 
      "fat levels", 
      "standard diet", 
      "animal models", 
      "semisynthetic diet", 
      "normal levels", 
      "tumor development", 
      "day 50", 
      "fat content", 
      "supplementation", 
      "diet", 
      "tumorigenesis", 
      "rats", 
      "levels", 
      "MNU", 
      "months", 
      "carcinogenesis", 
      "vitamin", 
      "fat", 
      "effect", 
      "animals", 
      "days", 
      "different fat levels", 
      "aim", 
      "initiation", 
      "high amounts", 
      "period", 
      "study", 
      "life", 
      "correlation", 
      "development", 
      "content", 
      "results", 
      "amount", 
      "model", 
      "experiments", 
      "energy"
    ], 
    "name": "Effects of vitamin A and E supplementation to diets containing two different fat levels on methylnitrosourea-induced mammary carcinogenesis in female SD-rats", 
    "pagination": "445-449", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019905374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1987.221"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3689661"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1987.221", 
      "https://app.dimensions.ai/details/publication/pub.1019905374"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_186.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/bjc.1987.221"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.221'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.221'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.221'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.221'


 

This table displays all metadata directly associated to this object as RDF triples.

175 TRIPLES      21 PREDICATES      86 URIs      76 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1987.221 schema:about N1438abf632124fd3b938830978f5614d
2 N33d27e2922d54dcbb02cc69fd6650091
3 N358cc80065794d8689057e83143473f2
4 N4255583f54cd4e0db2cb5b5e444968cc
5 N4335d654000e4da68fde89f2e2f44c93
6 N5473315e4b084554a818347203709e62
7 N5ec3b1e36ca3496785ecf795e4106b24
8 N85faaad47f7d42078bf3c326c637650d
9 Nc6931bdbf0d9484c9512faa5051a9b8d
10 Ne3f271c868c94a31aae0be8523412bc7
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N913817f193704c6bb08c6e6c9bbb5cc5
14 schema:citation sg:pub.10.1007/bf01900187
15 sg:pub.10.1038/267620a0
16 schema:datePublished 1987-12
17 schema:datePublishedReg 1987-12-01
18 schema:description The aim of this study was to elucidate the effects of dietary vitamin A and E supplementation on tumorigenesis in correlation to the fat content of the respective diet in an animal model. One hundred and twenty female SD rats were initiated intravenously with 25 mg MNU kg-1 on day 50 of life. For a period of 6 months, beginning after the day of initiation, all animals received a semisynthetic diet containing 25% or 45% of the energy as fat, supplemented either with a 10-fold higher amount of naturally occurring vitamins A and E than in rat standard diets or, with a normal level of these vitamins. The experiment showed: (1) Vitamin A and E supplementation showed no significant chemopreventive effect against mammary tumour development. (2) This result was independent from the supplied fat level of the respective diet. (3) The fat content per se did not significantly influence mammary tumorigenesis.
19 schema:genre article
20 schema:isAccessibleForFree true
21 schema:isPartOf N054310fcb35b43958679337e126eeb97
22 Ncc8a01169a6d4b7e90c3563e6c46cd13
23 sg:journal.1017082
24 schema:keywords E supplementation
25 MNU
26 SD rats
27 aim
28 amount
29 animal models
30 animals
31 carcinogenesis
32 chemopreventive effects
33 content
34 correlation
35 day 50
36 days
37 days of initiation
38 development
39 diet
40 dietary vitamin A
41 different fat levels
42 effect
43 energy
44 experiments
45 fat
46 fat content
47 fat levels
48 female SD rats
49 high amounts
50 initiation
51 levels
52 life
53 mammary carcinogenesis
54 mammary tumor development
55 mammary tumorigenesis
56 model
57 months
58 normal levels
59 period
60 rats
61 respective diets
62 results
63 semisynthetic diet
64 significant chemopreventive effect
65 standard diet
66 study
67 supplementation
68 tumor development
69 tumorigenesis
70 vitamin
71 vitamin A
72 schema:name Effects of vitamin A and E supplementation to diets containing two different fat levels on methylnitrosourea-induced mammary carcinogenesis in female SD-rats
73 schema:pagination 445-449
74 schema:productId N3e68b5c09db0476ba7d6e1bbb677b00f
75 Nc95d22be8b9e4a5eac1262f87f6469cd
76 Nd898774e14024d6b823e845defab6f0d
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019905374
78 https://doi.org/10.1038/bjc.1987.221
79 schema:sdDatePublished 2022-12-01T06:19
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N17b3c7acccd14f93a6b1a3b1314ffbdb
82 schema:url https://doi.org/10.1038/bjc.1987.221
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N054310fcb35b43958679337e126eeb97 schema:issueNumber 4
87 rdf:type schema:PublicationIssue
88 N1438abf632124fd3b938830978f5614d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Dietary Fats
90 rdf:type schema:DefinedTerm
91 N17b3c7acccd14f93a6b1a3b1314ffbdb schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N2b78d485f6cd4e96b9e2488f21bd2067 rdf:first sg:person.0105462430.55
94 rdf:rest rdf:nil
95 N33d27e2922d54dcbb02cc69fd6650091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Animals
97 rdf:type schema:DefinedTerm
98 N358cc80065794d8689057e83143473f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Mammary Neoplasms, Experimental
100 rdf:type schema:DefinedTerm
101 N3e68b5c09db0476ba7d6e1bbb677b00f schema:name doi
102 schema:value 10.1038/bjc.1987.221
103 rdf:type schema:PropertyValue
104 N4255583f54cd4e0db2cb5b5e444968cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Vitamin A
106 rdf:type schema:DefinedTerm
107 N4335d654000e4da68fde89f2e2f44c93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N441f24d6336443588ddbb4c9d3d31a16 rdf:first sg:person.01017036027.48
111 rdf:rest N2b78d485f6cd4e96b9e2488f21bd2067
112 N5473315e4b084554a818347203709e62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Rats
114 rdf:type schema:DefinedTerm
115 N5a12d41db6dc453282f51e1ab19559ba rdf:first sg:person.01256203524.22
116 rdf:rest N441f24d6336443588ddbb4c9d3d31a16
117 N5ec3b1e36ca3496785ecf795e4106b24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Methylnitrosourea
119 rdf:type schema:DefinedTerm
120 N85faaad47f7d42078bf3c326c637650d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Vitamin E
122 rdf:type schema:DefinedTerm
123 N913817f193704c6bb08c6e6c9bbb5cc5 rdf:first sg:person.01172047773.27
124 rdf:rest N5a12d41db6dc453282f51e1ab19559ba
125 Nc6931bdbf0d9484c9512faa5051a9b8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Body Weight
127 rdf:type schema:DefinedTerm
128 Nc95d22be8b9e4a5eac1262f87f6469cd schema:name dimensions_id
129 schema:value pub.1019905374
130 rdf:type schema:PropertyValue
131 Ncc8a01169a6d4b7e90c3563e6c46cd13 schema:volumeNumber 56
132 rdf:type schema:PublicationVolume
133 Nd898774e14024d6b823e845defab6f0d schema:name pubmed_id
134 schema:value 3689661
135 rdf:type schema:PropertyValue
136 Ne3f271c868c94a31aae0be8523412bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Rats, Inbred Strains
138 rdf:type schema:DefinedTerm
139 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
140 schema:name Medical and Health Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
143 schema:name Clinical Sciences
144 rdf:type schema:DefinedTerm
145 sg:journal.1017082 schema:issn 0007-0920
146 1532-1827
147 schema:name British Journal of Cancer
148 schema:publisher Springer Nature
149 rdf:type schema:Periodical
150 sg:person.01017036027.48 schema:familyName Aksoy
151 schema:givenName M
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017036027.48
153 rdf:type schema:Person
154 sg:person.0105462430.55 schema:familyName Schmähl
155 schema:givenName D
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105462430.55
157 rdf:type schema:Person
158 sg:person.01172047773.27 schema:affiliation grid-institutes:grid.7497.d
159 schema:familyName Beth
160 schema:givenName M
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172047773.27
162 rdf:type schema:Person
163 sg:person.01256203524.22 schema:familyName Berger
164 schema:givenName MR
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22
166 rdf:type schema:Person
167 sg:pub.10.1007/bf01900187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015935443
168 https://doi.org/10.1007/bf01900187
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/267620a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035223096
171 https://doi.org/10.1038/267620a0
172 rdf:type schema:CreativeWork
173 grid-institutes:grid.7497.d schema:alternateName Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg
174 schema:name Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg
175 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...