Oestrogen receptors in primary and advanced breast cancer: An eight year review of 704 cases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1987-01

AUTHORS

M R Williams, J H Todd, I O Ellis, C S Dowle, J L Haybittle, C W Elston, R I Nicholson, K Griffiths, R W Blamey

ABSTRACT

ER content of primary tumour tissue has been examined in 704 patients presenting with operable breast cancer. The median follow-up is now 84 months and no patient has received adjuvant therapy of any kind. ER status is related to histological grade, menopausal status, initial site of metastases and subsequent response to endocrine therapy. A significant advantage in terms of survival is found in ER positive patients which is confined to those lymph node positive at mastectomy. DFI is also significantly related to ER status in lymph node positive patients. Survival after the symptomatic presentation of metastases and the institution of endocrine therapy is prolonged in patients with ER positive tumours. The overall response rate to endocrine therapy in assessable patients with ER positive tumours is 32%. By combining the ER status and histological grade of tumour tissue, a group of patients comprising 28% of those assessable to endocrine therapy can be identified (ER positive, grade I and II) with a response rate of 46%. More... »

PAGES

67

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1987.14

DOI

http://dx.doi.org/10.1038/bjc.1987.14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004831077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3814477


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Menopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Williams", 
        "givenName": "M R", 
        "id": "sg:person.0747422207.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747422207.13"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Todd", 
        "givenName": "J H", 
        "id": "sg:person.014570324437.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014570324437.16"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ellis", 
        "givenName": "I O", 
        "id": "sg:person.01054612302.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Dowle", 
        "givenName": "C S", 
        "id": "sg:person.01257377412.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257377412.18"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Haybittle", 
        "givenName": "J L", 
        "id": "sg:person.063512001.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063512001.95"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Elston", 
        "givenName": "C W", 
        "id": "sg:person.014602255114.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014602255114.93"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nicholson", 
        "givenName": "R I", 
        "id": "sg:person.07624775312.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624775312.85"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Griffiths", 
        "givenName": "K", 
        "id": "sg:person.01112542605.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112542605.67"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Blamey", 
        "givenName": "R W", 
        "id": "sg:person.015650304144.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(79)90295-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000600419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(79)90295-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000600419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-2197.1985.tb00870.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000808115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(79)92752-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001375185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1982.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001864868", 
          "https://doi.org/10.1038/bjc.1982.62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1982.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001864868", 
          "https://doi.org/10.1038/bjc.1982.62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01886733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007616901", 
          "https://doi.org/10.1007/bf01886733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01886733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007616901", 
          "https://doi.org/10.1007/bf01886733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197703)39:3<1289::aid-cncr2820390340>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011360956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19841115)54:10<2237::aid-cncr2820541029>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012297783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(81)90459-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012720611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(81)90459-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012720611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(82)90241-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012932426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19801215)46:12+<2884::aid-cncr2820461429>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013410025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19810201)47:3<554::aid-cncr2820470322>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016431867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(81)90275-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017928234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(81)90275-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017928234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19810515)47:10<2364::aid-cncr2820471007>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018075999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1982.01380300001001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019695323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1978.282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020541320", 
          "https://doi.org/10.1038/bjc.1978.282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1978.282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020541320", 
          "https://doi.org/10.1038/bjc.1978.282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02235743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021268405", 
          "https://doi.org/10.1007/bf02235743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02235743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021268405", 
          "https://doi.org/10.1007/bf02235743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19800415)45:8<1993::aid-cncr2820450802>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023436923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1984.234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038323438", 
          "https://doi.org/10.1038/bjc.1984.234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1984.234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038323438", 
          "https://doi.org/10.1038/bjc.1984.234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1985.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041632172", 
          "https://doi.org/10.1038/bjc.1985.38"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1985.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041632172", 
          "https://doi.org/10.1038/bjc.1985.38"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19840601)53:11<2525::aid-cncr2820531126>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043089316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2964(80)90348-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043667003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19801215)46:12+<2765::aid-cncr2820461404>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044495948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1981.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046204724", 
          "https://doi.org/10.1038/bjc.1981.205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1981.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046204724", 
          "https://doi.org/10.1038/bjc.1981.205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)90995-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047356072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1978.225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051330643", 
          "https://doi.org/10.1038/bjc.1978.225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1978.225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051330643", 
          "https://doi.org/10.1038/bjc.1978.225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080577491", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081876236", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082086116", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083118733", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1987-01", 
    "datePublishedReg": "1987-01-01", 
    "description": "ER content of primary tumour tissue has been examined in 704 patients presenting with operable breast cancer. The median follow-up is now 84 months and no patient has received adjuvant therapy of any kind. ER status is related to histological grade, menopausal status, initial site of metastases and subsequent response to endocrine therapy. A significant advantage in terms of survival is found in ER positive patients which is confined to those lymph node positive at mastectomy. DFI is also significantly related to ER status in lymph node positive patients. Survival after the symptomatic presentation of metastases and the institution of endocrine therapy is prolonged in patients with ER positive tumours. The overall response rate to endocrine therapy in assessable patients with ER positive tumours is 32%. By combining the ER status and histological grade of tumour tissue, a group of patients comprising 28% of those assessable to endocrine therapy can be identified (ER positive, grade I and II) with a response rate of 46%.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1987.14", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "Oestrogen receptors in primary and advanced breast cancer: An eight year review of 704 cases", 
    "pagination": "67", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "170546be7df5517bf00fa50ceb2139121bbb5989060c853d44bef776989b1020"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3814477"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1987.14"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004831077"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1987.14", 
      "https://app.dimensions.ai/details/publication/pub.1004831077"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29222_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc198714"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.14'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.14'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.14'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1987.14'


 

This table displays all metadata directly associated to this object as RDF triples.

256 TRIPLES      21 PREDICATES      71 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1987.14 schema:about N26d91c4dacf24c968badf41b390a62ce
2 N30d6f14db604418a8373850f92f4aa67
3 N4e974cc999f84e7aa34dc2df05ce90b9
4 N4fbf8794fb0b417d986310ce896c51d9
5 N64bcd57252164e4480bd3f2d0c7bf108
6 N6de9dec7a40043088f3014c0dfbe587c
7 N8216df8e22e545ed86b38afb40f77d30
8 N9ee934fe643d4538b1092bfab570740c
9 Naad2ba65ef0046c9aec1c32eccdd8a3a
10 Nc029ae6510494dd2941dff5279950d1c
11 Ncd71f71c4b70404caa079d9c10a3c7f6
12 Nd8644a6d52354e8cb33cb08e242c61c2
13 Ne5ee0356027043d2bc2f9b027b8dd445
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N173ae273d1434180a217e456a1459f5c
17 schema:citation sg:pub.10.1007/bf01886733
18 sg:pub.10.1007/bf02235743
19 sg:pub.10.1038/bjc.1978.225
20 sg:pub.10.1038/bjc.1978.282
21 sg:pub.10.1038/bjc.1981.205
22 sg:pub.10.1038/bjc.1982.62
23 sg:pub.10.1038/bjc.1984.234
24 sg:pub.10.1038/bjc.1985.38
25 https://app.dimensions.ai/details/publication/pub.1080577491
26 https://app.dimensions.ai/details/publication/pub.1081876236
27 https://app.dimensions.ai/details/publication/pub.1082086116
28 https://app.dimensions.ai/details/publication/pub.1083118733
29 https://doi.org/10.1001/archsurg.1982.01380300001001
30 https://doi.org/10.1002/1097-0142(197703)39:3<1289::aid-cncr2820390340>3.0.co;2-f
31 https://doi.org/10.1002/1097-0142(19800415)45:8<1993::aid-cncr2820450802>3.0.co;2-2
32 https://doi.org/10.1002/1097-0142(19801215)46:12+<2765::aid-cncr2820461404>3.0.co;2-c
33 https://doi.org/10.1002/1097-0142(19801215)46:12+<2884::aid-cncr2820461429>3.0.co;2-u
34 https://doi.org/10.1002/1097-0142(19810201)47:3<554::aid-cncr2820470322>3.0.co;2-w
35 https://doi.org/10.1002/1097-0142(19810515)47:10<2364::aid-cncr2820471007>3.0.co;2-s
36 https://doi.org/10.1002/1097-0142(19840601)53:11<2525::aid-cncr2820531126>3.0.co;2-8
37 https://doi.org/10.1002/1097-0142(19841115)54:10<2237::aid-cncr2820541029>3.0.co;2-v
38 https://doi.org/10.1016/0014-2964(80)90348-5
39 https://doi.org/10.1016/0022-4731(81)90275-2
40 https://doi.org/10.1016/0277-5379(82)90241-3
41 https://doi.org/10.1016/s0140-6736(79)90295-2
42 https://doi.org/10.1016/s0140-6736(79)92752-1
43 https://doi.org/10.1016/s0140-6736(81)90459-1
44 https://doi.org/10.1016/s0140-6736(84)90995-4
45 https://doi.org/10.1111/j.1445-2197.1985.tb00870.x
46 schema:datePublished 1987-01
47 schema:datePublishedReg 1987-01-01
48 schema:description ER content of primary tumour tissue has been examined in 704 patients presenting with operable breast cancer. The median follow-up is now 84 months and no patient has received adjuvant therapy of any kind. ER status is related to histological grade, menopausal status, initial site of metastases and subsequent response to endocrine therapy. A significant advantage in terms of survival is found in ER positive patients which is confined to those lymph node positive at mastectomy. DFI is also significantly related to ER status in lymph node positive patients. Survival after the symptomatic presentation of metastases and the institution of endocrine therapy is prolonged in patients with ER positive tumours. The overall response rate to endocrine therapy in assessable patients with ER positive tumours is 32%. By combining the ER status and histological grade of tumour tissue, a group of patients comprising 28% of those assessable to endocrine therapy can be identified (ER positive, grade I and II) with a response rate of 46%.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N2ced85d4e0b8465ea5aee07e1641bfc4
53 Ndbf008fd5a02466697e594d9e267a3b1
54 sg:journal.1017082
55 schema:name Oestrogen receptors in primary and advanced breast cancer: An eight year review of 704 cases
56 schema:pagination 67
57 schema:productId N4e74b666e9cb426b91d1f52780f67613
58 N6afe071c36e844b388dd8bbff48da98d
59 N883f39e94d4448a8b49d3b0f2375ec06
60 Nae5f9ce88f9943a389086c909ce28ee1
61 Nee488281ccf749f5b471c7ba1888add2
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004831077
63 https://doi.org/10.1038/bjc.1987.14
64 schema:sdDatePublished 2019-04-11T11:57
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N1c0b85d0f3df471687dfc8d34fd15fb2
67 schema:url https://www.nature.com/articles/bjc198714
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N173ae273d1434180a217e456a1459f5c rdf:first sg:person.0747422207.13
72 rdf:rest N77298ebde7e24f90b48805fa073912c1
73 N1c0b85d0f3df471687dfc8d34fd15fb2 schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 N26d91c4dacf24c968badf41b390a62ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Time Factors
77 rdf:type schema:DefinedTerm
78 N2ced85d4e0b8465ea5aee07e1641bfc4 schema:issueNumber 1
79 rdf:type schema:PublicationIssue
80 N30d6f14db604418a8373850f92f4aa67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Humans
82 rdf:type schema:DefinedTerm
83 N44253c3d3a6846dab1887cd7784cd546 rdf:first sg:person.063512001.95
84 rdf:rest N6b1fa020aad445feb0130bc42ba6417a
85 N463cc0c23e1d44aa8a07c59b850ea63a rdf:first sg:person.07624775312.85
86 rdf:rest Nbbd18af32adb4228b7cc33b56e815d15
87 N4e74b666e9cb426b91d1f52780f67613 schema:name doi
88 schema:value 10.1038/bjc.1987.14
89 rdf:type schema:PropertyValue
90 N4e974cc999f84e7aa34dc2df05ce90b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Female
92 rdf:type schema:DefinedTerm
93 N4fbf8794fb0b417d986310ce896c51d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Lymph Nodes
95 rdf:type schema:DefinedTerm
96 N64bcd57252164e4480bd3f2d0c7bf108 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Menopause
98 rdf:type schema:DefinedTerm
99 N6afe071c36e844b388dd8bbff48da98d schema:name readcube_id
100 schema:value 170546be7df5517bf00fa50ceb2139121bbb5989060c853d44bef776989b1020
101 rdf:type schema:PropertyValue
102 N6b1fa020aad445feb0130bc42ba6417a rdf:first sg:person.014602255114.93
103 rdf:rest N463cc0c23e1d44aa8a07c59b850ea63a
104 N6de9dec7a40043088f3014c0dfbe587c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Breast Neoplasms
106 rdf:type schema:DefinedTerm
107 N77298ebde7e24f90b48805fa073912c1 rdf:first sg:person.014570324437.16
108 rdf:rest Ncbed6a21db504983a40e155af175d026
109 N8216df8e22e545ed86b38afb40f77d30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Animals
111 rdf:type schema:DefinedTerm
112 N883f39e94d4448a8b49d3b0f2375ec06 schema:name nlm_unique_id
113 schema:value 0370635
114 rdf:type schema:PropertyValue
115 N9ca879e57c9b4dff8a8a8e50e78885da rdf:first sg:person.015650304144.58
116 rdf:rest rdf:nil
117 N9ee934fe643d4538b1092bfab570740c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Prognosis
119 rdf:type schema:DefinedTerm
120 Naad2ba65ef0046c9aec1c32eccdd8a3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Bone Neoplasms
122 rdf:type schema:DefinedTerm
123 Nae5f9ce88f9943a389086c909ce28ee1 schema:name pubmed_id
124 schema:value 3814477
125 rdf:type schema:PropertyValue
126 Nb5a7938c76bd452e9314386a6e494e7a rdf:first sg:person.01257377412.18
127 rdf:rest N44253c3d3a6846dab1887cd7784cd546
128 Nbbd18af32adb4228b7cc33b56e815d15 rdf:first sg:person.01112542605.67
129 rdf:rest N9ca879e57c9b4dff8a8a8e50e78885da
130 Nc029ae6510494dd2941dff5279950d1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Middle Aged
132 rdf:type schema:DefinedTerm
133 Ncbed6a21db504983a40e155af175d026 rdf:first sg:person.01054612302.65
134 rdf:rest Nb5a7938c76bd452e9314386a6e494e7a
135 Ncd71f71c4b70404caa079d9c10a3c7f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aged
137 rdf:type schema:DefinedTerm
138 Nd8644a6d52354e8cb33cb08e242c61c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Receptors, Estrogen
140 rdf:type schema:DefinedTerm
141 Ndbf008fd5a02466697e594d9e267a3b1 schema:volumeNumber 55
142 rdf:type schema:PublicationVolume
143 Ne5ee0356027043d2bc2f9b027b8dd445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Lung Neoplasms
145 rdf:type schema:DefinedTerm
146 Nee488281ccf749f5b471c7ba1888add2 schema:name dimensions_id
147 schema:value pub.1004831077
148 rdf:type schema:PropertyValue
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
153 schema:name Oncology and Carcinogenesis
154 rdf:type schema:DefinedTerm
155 sg:journal.1017082 schema:issn 0007-0920
156 1532-1827
157 schema:name British Journal of Cancer
158 rdf:type schema:Periodical
159 sg:person.01054612302.65 schema:familyName Ellis
160 schema:givenName I O
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65
162 rdf:type schema:Person
163 sg:person.01112542605.67 schema:familyName Griffiths
164 schema:givenName K
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112542605.67
166 rdf:type schema:Person
167 sg:person.01257377412.18 schema:familyName Dowle
168 schema:givenName C S
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257377412.18
170 rdf:type schema:Person
171 sg:person.014570324437.16 schema:familyName Todd
172 schema:givenName J H
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014570324437.16
174 rdf:type schema:Person
175 sg:person.014602255114.93 schema:familyName Elston
176 schema:givenName C W
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014602255114.93
178 rdf:type schema:Person
179 sg:person.015650304144.58 schema:familyName Blamey
180 schema:givenName R W
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58
182 rdf:type schema:Person
183 sg:person.063512001.95 schema:familyName Haybittle
184 schema:givenName J L
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063512001.95
186 rdf:type schema:Person
187 sg:person.0747422207.13 schema:familyName Williams
188 schema:givenName M R
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747422207.13
190 rdf:type schema:Person
191 sg:person.07624775312.85 schema:familyName Nicholson
192 schema:givenName R I
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624775312.85
194 rdf:type schema:Person
195 sg:pub.10.1007/bf01886733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007616901
196 https://doi.org/10.1007/bf01886733
197 rdf:type schema:CreativeWork
198 sg:pub.10.1007/bf02235743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021268405
199 https://doi.org/10.1007/bf02235743
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/bjc.1978.225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051330643
202 https://doi.org/10.1038/bjc.1978.225
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/bjc.1978.282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020541320
205 https://doi.org/10.1038/bjc.1978.282
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/bjc.1981.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046204724
208 https://doi.org/10.1038/bjc.1981.205
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/bjc.1982.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001864868
211 https://doi.org/10.1038/bjc.1982.62
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/bjc.1984.234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038323438
214 https://doi.org/10.1038/bjc.1984.234
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/bjc.1985.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041632172
217 https://doi.org/10.1038/bjc.1985.38
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1080577491 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1081876236 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1082086116 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1083118733 schema:CreativeWork
223 https://doi.org/10.1001/archsurg.1982.01380300001001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019695323
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1002/1097-0142(197703)39:3<1289::aid-cncr2820390340>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1011360956
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/1097-0142(19800415)45:8<1993::aid-cncr2820450802>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023436923
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/1097-0142(19801215)46:12+<2765::aid-cncr2820461404>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1044495948
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/1097-0142(19801215)46:12+<2884::aid-cncr2820461429>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1013410025
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/1097-0142(19810201)47:3<554::aid-cncr2820470322>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1016431867
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/1097-0142(19810515)47:10<2364::aid-cncr2820471007>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1018075999
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/1097-0142(19840601)53:11<2525::aid-cncr2820531126>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043089316
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/1097-0142(19841115)54:10<2237::aid-cncr2820541029>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1012297783
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0014-2964(80)90348-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043667003
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0022-4731(81)90275-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017928234
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0277-5379(82)90241-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012932426
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0140-6736(79)90295-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000600419
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0140-6736(79)92752-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001375185
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0140-6736(81)90459-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012720611
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0140-6736(84)90995-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047356072
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/j.1445-2197.1985.tb00870.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000808115
256 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...