The use of antisera to epithelial membrane antigen in detecting micrometastases in histological sections View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1980-09

AUTHORS

J P Sloane, M G Ormerod, S F Imrie, R C Coombes

ABSTRACT

We have investigated, by immunocytochemical means, the value of an antiserum raised to milk-fat-globule membranes in detecting metastatic deposits of breast carcinoma in conventional histological sections of liver, lymph nodes and marrow. The antiseum recognizes a membrane component, which we have called Epithelial Membrane Antigen, and which is confined to but widely distributed in epithelial tissues and tumours derived from them. In the sections examined, a greater extent of tumour infiltration was usually found, largely due to the identification of single malignant cells which normally go unrecognized with conventional stains. The number of positive samples was only increased, however, in sections of marrow aspirates, and the reasons for this are discussed. We suggest that further increases in detection rates could be attained by using the antiserum on cytological smears of marrow or even in cell suspensions. More... »

PAGES

392

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1980.250

DOI

http://dx.doi.org/10.1038/bjc.1980.250

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013980813

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7000115


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Sloane", 
        "givenName": "J P", 
        "id": "sg:person.01205560342.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205560342.38"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ormerod", 
        "givenName": "M G", 
        "id": "sg:person.0607051640.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607051640.89"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Imrie", 
        "givenName": "S F", 
        "id": "sg:person.0734521673.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734521673.06"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Coombes", 
        "givenName": "R C", 
        "id": "sg:person.07545770237.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07545770237.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.74.2.582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017679437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0019-2791(71)90395-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020774953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0019-2791(71)90395-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020774953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.32.1.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023585399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.30.2.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041966394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19810401)47:7<1786::aid-cncr2820470711>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044104357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(80)90790-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051432325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(80)90790-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051432325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/22.12.1084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064086726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/22.12.1084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064086726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082330501", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1980-09", 
    "datePublishedReg": "1980-09-01", 
    "description": "We have investigated, by immunocytochemical means, the value of an antiserum raised to milk-fat-globule membranes in detecting metastatic deposits of breast carcinoma in conventional histological sections of liver, lymph nodes and marrow. The antiseum recognizes a membrane component, which we have called Epithelial Membrane Antigen, and which is confined to but widely distributed in epithelial tissues and tumours derived from them. In the sections examined, a greater extent of tumour infiltration was usually found, largely due to the identification of single malignant cells which normally go unrecognized with conventional stains. The number of positive samples was only increased, however, in sections of marrow aspirates, and the reasons for this are discussed. We suggest that further increases in detection rates could be attained by using the antiserum on cytological smears of marrow or even in cell suspensions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.1980.250", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "The use of antisera to epithelial membrane antigen in detecting micrometastases in histological sections", 
    "pagination": "392", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4299cabd2d6347e4e046602bf1cd6b1acbd9802981bead20a973200139f69e15"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7000115"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1980.250"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013980813"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1980.250", 
      "https://app.dimensions.ai/details/publication/pub.1013980813"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118306_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc1980250"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1980.250'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1980.250'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1980.250'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1980.250'


 

This table displays all metadata directly associated to this object as RDF triples.

158 TRIPLES      21 PREDICATES      50 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1980.250 schema:about N3803200541534d84801fd582fe43f95e
2 N45dd16f7b2f34def9ff279a5dfd32651
3 N4f62154fed0a4f13871579573773f6a3
4 N62cda8209c2d49d49ff0257d29da5455
5 N6475e9207b6e4672a1c701520ba2b583
6 N7b48d28616994ac193b149df579d0e6c
7 N8d88bc15e799405fbd469d1c8e29c762
8 N94f0ab67c0144cb0acbf2f716b3098e6
9 N9c216779141a47b69703415637d72c45
10 Nb4032dbe60aa47c8b877f4d02783365b
11 Ne5f7496f94454e70a37d63775eb7f1bd
12 Nf7fbb1ebb3ec46ccbcc6b561146ea7e9
13 Nfa9bc56853f14f0b8b398fb03f647184
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author Ned7b6768893943d9b52929550e294260
17 schema:citation https://app.dimensions.ai/details/publication/pub.1082330501
18 https://doi.org/10.1002/1097-0142(19810401)47:7<1786::aid-cncr2820470711>3.0.co;2-8
19 https://doi.org/10.1016/0019-2791(71)90395-8
20 https://doi.org/10.1016/s0140-6736(80)90790-4
21 https://doi.org/10.1073/pnas.74.2.582
22 https://doi.org/10.1136/jcp.30.2.138
23 https://doi.org/10.1136/jcp.32.1.35
24 https://doi.org/10.1177/22.12.1084
25 schema:datePublished 1980-09
26 schema:datePublishedReg 1980-09-01
27 schema:description We have investigated, by immunocytochemical means, the value of an antiserum raised to milk-fat-globule membranes in detecting metastatic deposits of breast carcinoma in conventional histological sections of liver, lymph nodes and marrow. The antiseum recognizes a membrane component, which we have called Epithelial Membrane Antigen, and which is confined to but widely distributed in epithelial tissues and tumours derived from them. In the sections examined, a greater extent of tumour infiltration was usually found, largely due to the identification of single malignant cells which normally go unrecognized with conventional stains. The number of positive samples was only increased, however, in sections of marrow aspirates, and the reasons for this are discussed. We suggest that further increases in detection rates could be attained by using the antiserum on cytological smears of marrow or even in cell suspensions.
28 schema:genre research_article
29 schema:inLanguage en
30 schema:isAccessibleForFree true
31 schema:isPartOf N462b6d1adb324110873f1cc97098d28f
32 Nb4a9fafc99dd488886ffd24c2db62295
33 sg:journal.1017082
34 schema:name The use of antisera to epithelial membrane antigen in detecting micrometastases in histological sections
35 schema:pagination 392
36 schema:productId N235b22118acf4005bf129f350a7382d5
37 N37e48f65e3e243fb9e032b3d62c32e65
38 N409944c39d7c4cfa8c3aa4a82da344dc
39 Na0febd5b8a3d4330a047bc269b776d42
40 Na5fd1d4bbb894be59d0f27f36891d6a8
41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013980813
42 https://doi.org/10.1038/bjc.1980.250
43 schema:sdDatePublished 2019-04-11T12:03
44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
45 schema:sdPublisher Nd96cbf6f22da446eb507de5161cb7a39
46 schema:url https://www.nature.com/articles/bjc1980250
47 sgo:license sg:explorer/license/
48 sgo:sdDataset articles
49 rdf:type schema:ScholarlyArticle
50 N235b22118acf4005bf129f350a7382d5 schema:name nlm_unique_id
51 schema:value 0370635
52 rdf:type schema:PropertyValue
53 N37e48f65e3e243fb9e032b3d62c32e65 schema:name readcube_id
54 schema:value 4299cabd2d6347e4e046602bf1cd6b1acbd9802981bead20a973200139f69e15
55 rdf:type schema:PropertyValue
56 N3803200541534d84801fd582fe43f95e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Antigens, Neoplasm
58 rdf:type schema:DefinedTerm
59 N388d362a123c42dca43800e0d68cc11a rdf:first sg:person.07545770237.14
60 rdf:rest rdf:nil
61 N409944c39d7c4cfa8c3aa4a82da344dc schema:name dimensions_id
62 schema:value pub.1013980813
63 rdf:type schema:PropertyValue
64 N45dd16f7b2f34def9ff279a5dfd32651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Bone Marrow
66 rdf:type schema:DefinedTerm
67 N462b6d1adb324110873f1cc97098d28f schema:volumeNumber 42
68 rdf:type schema:PublicationVolume
69 N4f62154fed0a4f13871579573773f6a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name In Vitro Techniques
71 rdf:type schema:DefinedTerm
72 N62cda8209c2d49d49ff0257d29da5455 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Epithelium
74 rdf:type schema:DefinedTerm
75 N6475e9207b6e4672a1c701520ba2b583 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Humans
77 rdf:type schema:DefinedTerm
78 N7226149988ca495bbe9e9fac12d0a9c4 rdf:first sg:person.0734521673.06
79 rdf:rest N388d362a123c42dca43800e0d68cc11a
80 N7b48d28616994ac193b149df579d0e6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Liver Neoplasms
82 rdf:type schema:DefinedTerm
83 N8d88bc15e799405fbd469d1c8e29c762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Breast Neoplasms
85 rdf:type schema:DefinedTerm
86 N94f0ab67c0144cb0acbf2f716b3098e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Neoplasm Metastasis
88 rdf:type schema:DefinedTerm
89 N9c216779141a47b69703415637d72c45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Immunoenzyme Techniques
91 rdf:type schema:DefinedTerm
92 Na0febd5b8a3d4330a047bc269b776d42 schema:name pubmed_id
93 schema:value 7000115
94 rdf:type schema:PropertyValue
95 Na5fd1d4bbb894be59d0f27f36891d6a8 schema:name doi
96 schema:value 10.1038/bjc.1980.250
97 rdf:type schema:PropertyValue
98 Nb4032dbe60aa47c8b877f4d02783365b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Female
100 rdf:type schema:DefinedTerm
101 Nb4a9fafc99dd488886ffd24c2db62295 schema:issueNumber 3
102 rdf:type schema:PublicationIssue
103 Nc39552983ed04c908c3a44ab07dc43fa rdf:first sg:person.0607051640.89
104 rdf:rest N7226149988ca495bbe9e9fac12d0a9c4
105 Nd96cbf6f22da446eb507de5161cb7a39 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Ne5f7496f94454e70a37d63775eb7f1bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Lymph Nodes
109 rdf:type schema:DefinedTerm
110 Ned7b6768893943d9b52929550e294260 rdf:first sg:person.01205560342.38
111 rdf:rest Nc39552983ed04c908c3a44ab07dc43fa
112 Nf7fbb1ebb3ec46ccbcc6b561146ea7e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Lymphatic Metastasis
114 rdf:type schema:DefinedTerm
115 Nfa9bc56853f14f0b8b398fb03f647184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Membrane
117 rdf:type schema:DefinedTerm
118 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
119 schema:name Medical and Health Sciences
120 rdf:type schema:DefinedTerm
121 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
122 schema:name Oncology and Carcinogenesis
123 rdf:type schema:DefinedTerm
124 sg:journal.1017082 schema:issn 0007-0920
125 1532-1827
126 schema:name British Journal of Cancer
127 rdf:type schema:Periodical
128 sg:person.01205560342.38 schema:familyName Sloane
129 schema:givenName J P
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205560342.38
131 rdf:type schema:Person
132 sg:person.0607051640.89 schema:familyName Ormerod
133 schema:givenName M G
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607051640.89
135 rdf:type schema:Person
136 sg:person.0734521673.06 schema:familyName Imrie
137 schema:givenName S F
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734521673.06
139 rdf:type schema:Person
140 sg:person.07545770237.14 schema:familyName Coombes
141 schema:givenName R C
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07545770237.14
143 rdf:type schema:Person
144 https://app.dimensions.ai/details/publication/pub.1082330501 schema:CreativeWork
145 https://doi.org/10.1002/1097-0142(19810401)47:7<1786::aid-cncr2820470711>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044104357
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/0019-2791(71)90395-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020774953
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/s0140-6736(80)90790-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051432325
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1073/pnas.74.2.582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017679437
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1136/jcp.30.2.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041966394
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1136/jcp.32.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023585399
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1177/22.12.1084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064086726
158 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...