Improved immune-suppression techniques for the xenografting of human tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1978-02

AUTHORS

G G Steel, V D Courtenay, A Y Rostom

ABSTRACT

The transplantability of a xenografted human adenocarcinoma has been examined in mice that had been immune-suppressed by thymectomy and whole-body irradiation and the results have been compared with transplantation into athymic (nude) mice. Two alternative techniques were used to prevent marrow failure following whole-body irradiation: reconstituting the animals with a marrow graft, or protecting them by an injection of cytosine arabinoside (Ara-C) 2 days before the irradiation. The results show that the Ara-C-prepared mice were more receptive to transplantation than marrow-grafted or nude mice, and they were the only animals that developed regional metastases from implanted xenografts. Some recovery of immunity occurred in both types of immune-suppressed mice, which was evident more than 5 weeks after immune-suppression and which was more marked in females than in males. It was concluded that the immune-suppressed mice were superior to nude mice for short-term experiments but they may be less satisfactory for long-term experiments. More... »

PAGES

224-230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1978.30

DOI

http://dx.doi.org/10.1038/bjc.1978.30

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040345971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/343803


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