Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1976-04

AUTHORS

F R Balkwill, R T Oliver

ABSTRACT

A simple liquid culture technique has been used to study peripheral blood from patients with acute myelogenous leukaemia. Evidence is presented that cells from morphologically identical types of leukaemia have differing capacity for "differentiation" from free floating blast cells into plastic-adherent phagocytic, trypsin-resistant macrophage-like cells with Fc and C3 receptors. Preliminary analysis suggests that patients whose cells have the greatest capacity for "differentiation" have a better chance of achieving complete remission. More... »

PAGES

400-410

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1976.65

DOI

http://dx.doi.org/10.1038/bjc.1976.65

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052384868

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1063591


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement C3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Fc Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phagocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phagocytosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trypsin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Balkwill", 
        "givenName": "F R", 
        "id": "sg:person.016530027317.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016530027317.07"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Oliver", 
        "givenName": "R T", 
        "id": "sg:person.01241731212.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241731212.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/icb.1966.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010996922", 
          "https://doi.org/10.1038/icb.1966.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/250667a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022657242", 
          "https://doi.org/10.1038/250667a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/251741a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004374869", 
          "https://doi.org/10.1038/251741a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1973.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023811750", 
          "https://doi.org/10.1038/bjc.1973.24"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1976-04", 
    "datePublishedReg": "1976-04-01", 
    "description": "A simple liquid culture technique has been used to study peripheral blood from patients with acute myelogenous leukaemia. Evidence is presented that cells from morphologically identical types of leukaemia have differing capacity for \"differentiation\" from free floating blast cells into plastic-adherent phagocytic, trypsin-resistant macrophage-like cells with Fc and C3 receptors. Preliminary analysis suggests that patients whose cells have the greatest capacity for \"differentiation\" have a better chance of achieving complete remission.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/bjc.1976.65", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "keywords": [
      "adult acute leukemia", 
      "acute myelogenous leukemia", 
      "macrophage-like cells", 
      "complete remission", 
      "prognostic significance", 
      "peripheral blood", 
      "acute leukemia", 
      "myelogenous leukemia", 
      "C3 receptors", 
      "blast cells", 
      "leukemia", 
      "patients", 
      "liquid culture technique", 
      "cells", 
      "best chance", 
      "remission", 
      "culture techniques", 
      "blood", 
      "receptors", 
      "differentiation", 
      "greater capacity", 
      "identical type", 
      "evidence", 
      "FC", 
      "significance", 
      "chance", 
      "capacity", 
      "preliminary analysis", 
      "types", 
      "analysis", 
      "characteristics", 
      "cultural characteristics", 
      "technique"
    ], 
    "name": "Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia", 
    "pagination": "400-410", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052384868"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.1976.65"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1063591"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.1976.65", 
      "https://app.dimensions.ai/details/publication/pub.1052384868"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T21:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_142.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/bjc.1976.65"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.1976.65'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.1976.65'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.1976.65'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.1976.65'


 

This table displays all metadata directly associated to this object as RDF triples.

173 TRIPLES      22 PREDICATES      79 URIs      67 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.1976.65 schema:about N04b897ed811749ef968223da40e13fa3
2 N10b90e53fd564155898cded38446f499
3 N39d0dfdb7c334377a9350e37ec363487
4 N438c24cdadaa4e048deb0a9c34a8b67d
5 N45878e646f174c30abefdf48f5e7c1f0
6 N71ee2d3f5bb943a4aa0eb0fdb3b2f1f9
7 N86871ed034f64b0685a9a1c6d657e2d3
8 N86915155402a40c5a033b4526967eaa9
9 Na31f660da13241b39e3048dd35ad2b87
10 Nb5223758561d4fd488f5cdf2cc8662b5
11 Nb875bfb594cb4d1eb2cca7cafbd53010
12 Nd3923a28f80842cb8368b2f826e1fa81
13 Ne542332321544213ab452f3d4165df23
14 Ne85aceb53b5f43ae82a9895ab650b423
15 Nf590187d40394360ae9e4e6e87795e8b
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author Nb7b4a65a60904ba7841a756321965e4c
19 schema:citation sg:pub.10.1038/250667a0
20 sg:pub.10.1038/251741a0
21 sg:pub.10.1038/bjc.1973.24
22 sg:pub.10.1038/icb.1966.28
23 schema:datePublished 1976-04
24 schema:datePublishedReg 1976-04-01
25 schema:description A simple liquid culture technique has been used to study peripheral blood from patients with acute myelogenous leukaemia. Evidence is presented that cells from morphologically identical types of leukaemia have differing capacity for "differentiation" from free floating blast cells into plastic-adherent phagocytic, trypsin-resistant macrophage-like cells with Fc and C3 receptors. Preliminary analysis suggests that patients whose cells have the greatest capacity for "differentiation" have a better chance of achieving complete remission.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree true
29 schema:isPartOf N5b46ab4cee2c4f209facabdbcce7e46f
30 N81a912be897c45449fe823decbb72228
31 sg:journal.1017082
32 schema:keywords C3 receptors
33 FC
34 acute leukemia
35 acute myelogenous leukemia
36 adult acute leukemia
37 analysis
38 best chance
39 blast cells
40 blood
41 capacity
42 cells
43 chance
44 characteristics
45 complete remission
46 cultural characteristics
47 culture techniques
48 differentiation
49 evidence
50 greater capacity
51 identical type
52 leukemia
53 liquid culture technique
54 macrophage-like cells
55 myelogenous leukemia
56 patients
57 peripheral blood
58 preliminary analysis
59 prognostic significance
60 receptors
61 remission
62 significance
63 technique
64 types
65 schema:name Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia
66 schema:pagination 400-410
67 schema:productId N54a1dc7733394c0db90d1309ea1e7c2e
68 N5e58993ee062436485fe9697d4a46cb4
69 N76e8a99f620044839c5294c5670fc0b6
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052384868
71 https://doi.org/10.1038/bjc.1976.65
72 schema:sdDatePublished 2022-06-01T21:57
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nc0f00916d583442e9f7229ebbb688da0
75 schema:url https://doi.org/10.1038/bjc.1976.65
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N04b897ed811749ef968223da40e13fa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Trypsin
81 rdf:type schema:DefinedTerm
82 N10b90e53fd564155898cded38446f499 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Cell Differentiation
84 rdf:type schema:DefinedTerm
85 N39d0dfdb7c334377a9350e37ec363487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Immunoglobulin Fc Fragments
87 rdf:type schema:DefinedTerm
88 N438c24cdadaa4e048deb0a9c34a8b67d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Leukemia, Myeloid, Acute
90 rdf:type schema:DefinedTerm
91 N45878e646f174c30abefdf48f5e7c1f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Mitosis
93 rdf:type schema:DefinedTerm
94 N54a1dc7733394c0db90d1309ea1e7c2e schema:name doi
95 schema:value 10.1038/bjc.1976.65
96 rdf:type schema:PropertyValue
97 N5b46ab4cee2c4f209facabdbcce7e46f schema:volumeNumber 33
98 rdf:type schema:PublicationVolume
99 N5e58993ee062436485fe9697d4a46cb4 schema:name dimensions_id
100 schema:value pub.1052384868
101 rdf:type schema:PropertyValue
102 N71ee2d3f5bb943a4aa0eb0fdb3b2f1f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Phagocytes
104 rdf:type schema:DefinedTerm
105 N76e8a99f620044839c5294c5670fc0b6 schema:name pubmed_id
106 schema:value 1063591
107 rdf:type schema:PropertyValue
108 N81a912be897c45449fe823decbb72228 schema:issueNumber 4
109 rdf:type schema:PublicationIssue
110 N86871ed034f64b0685a9a1c6d657e2d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 N86915155402a40c5a033b4526967eaa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Leukocytes
115 rdf:type schema:DefinedTerm
116 Na31f660da13241b39e3048dd35ad2b87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cell Survival
118 rdf:type schema:DefinedTerm
119 Nb5223758561d4fd488f5cdf2cc8662b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cell Adhesion
121 rdf:type schema:DefinedTerm
122 Nb7b4a65a60904ba7841a756321965e4c rdf:first sg:person.016530027317.07
123 rdf:rest Nd60902ad876d4e5ab728ba5b4febdc1d
124 Nb875bfb594cb4d1eb2cca7cafbd53010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Phagocytosis
126 rdf:type schema:DefinedTerm
127 Nc0f00916d583442e9f7229ebbb688da0 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 Nd3923a28f80842cb8368b2f826e1fa81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Binding Sites
131 rdf:type schema:DefinedTerm
132 Nd60902ad876d4e5ab728ba5b4febdc1d rdf:first sg:person.01241731212.85
133 rdf:rest rdf:nil
134 Ne542332321544213ab452f3d4165df23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Adult
136 rdf:type schema:DefinedTerm
137 Ne85aceb53b5f43ae82a9895ab650b423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cells, Cultured
139 rdf:type schema:DefinedTerm
140 Nf590187d40394360ae9e4e6e87795e8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Complement C3
142 rdf:type schema:DefinedTerm
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
147 schema:name Cardiorespiratory Medicine and Haematology
148 rdf:type schema:DefinedTerm
149 sg:journal.1017082 schema:issn 0007-0920
150 1532-1827
151 schema:name British Journal of Cancer
152 schema:publisher Springer Nature
153 rdf:type schema:Periodical
154 sg:person.01241731212.85 schema:familyName Oliver
155 schema:givenName R T
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241731212.85
157 rdf:type schema:Person
158 sg:person.016530027317.07 schema:familyName Balkwill
159 schema:givenName F R
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016530027317.07
161 rdf:type schema:Person
162 sg:pub.10.1038/250667a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022657242
163 https://doi.org/10.1038/250667a0
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/251741a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004374869
166 https://doi.org/10.1038/251741a0
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/bjc.1973.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023811750
169 https://doi.org/10.1038/bjc.1973.24
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/icb.1966.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010996922
172 https://doi.org/10.1038/icb.1966.28
173 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...