Induction of Bladder Tumours in Mice with Dibutylnitrosamine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1970-03

AUTHORS

J S Bertram, A W Craig

ABSTRACT

Dibutylnitrosamine has been administered continuously in the drinking water to two groups of C57BL/6 mice. The first group (50 males, 50 females) received 30 mg./kg./day and the second (50 males, 50 females) 7.6 mg./kg./day. Of mice reaching autopsy squamous cell carcinoma of the bladder was found in 44/90 at the high dose and 19/89 at the low dose. Bladder tumours were found predominantly in males, the ratio of tumours in males and females being 4.4: 1 and 8.5: 1 at the high and low dose levels, respectively. Carcinomas and papillomas of the oesophagus were found in all but 2 of the females and all but 6 of the males. In addition 5 carcinomas of the fore-stomach in the low dose group and a total in both groups of 13 tumours of the soft palate and tongue were found. The mean cumulative doses and respective induction times for the high and low dose groups were 7.4 and 2.0 g./kg., and 240 and 260 days. More... »

PAGES

352

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.1970.40

DOI

http://dx.doi.org/10.1038/bjc.1970.40

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049733809

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5451573


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