Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

J E Jang, Y H Min, J Yoon, I Kim, J-H Lee, C W Jung, H-J Shin, W S Lee, J H Lee, D-S Hong, H-J Kim, H-J Kim, S Park, K-H Lee, J H Jang, J S Chung, S M Lee, J Park, S K Park, J-S Ahn, W-S Min, J-W Cheong

ABSTRACT

Monosomal karyotype (MK) defined by either ⩾2 autosomal monosomies or single monosomy with at least one additional structural chromosomal abnormality is associated with a dismal prognosis in patients with acute myeloid leukemia (AML). It was detected in 174 of 3041 AML patients in South Korean Registry. A total of 119 patients who had received induction therapy were finally analyzed to evaluate the predictive factors for a positive prognosis. On multivariate analysis, single monosomy, the absence of abn(17p), ⩾10% of cells with normal metaphase and the achievement of a complete remission (CR) after induction therapy were significant factors for more favorable outcomes. Especially, single monosomy remained as a significantly independent prognostic factor for superior survival in both patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR and who did not. Allo-HSCT in CR improved overall survival significantly only in patients with a single monosomy. Our results suggest that MK-AML may be biologically different according to the karyotypic subtype and that allo-HSCT in CR should be strongly recommended to patients with a single monosomy. For other patients, more prudent treatment strategies should be examined. Furthermore, the biological mechanism by which a single monosomy influences survival should be investigated. More... »

PAGES

e358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bcj.2015.84

DOI

http://dx.doi.org/10.1038/bcj.2015.84

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031844660

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26473530


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