The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

M Díaz-Beyá, S Brunet, J Nomdedéu, A Cordeiro, M Tormo, L Escoda, J M Ribera, M Arnan, I Heras, D Gallardo, J Bargay, M P Queipo de Llano, O Salamero, J M Martí, A Sampol, C Pedro, M Hoyos, M Pratcorona, J J Castellano, M Nomdedeu, R M Risueño, J Sierra, M Monzó, A Navarro, J Esteve

ABSTRACT

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P=0.0025), shorter leukemia-free survival (P=0.026) and higher cumulative incidence of relapse (P=0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P=0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML. More... »

PAGES

e352

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bcj.2015.76

DOI

http://dx.doi.org/10.1038/bcj.2015.76

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045789175

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26430723


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