TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07

AUTHORS

H-A Hou, W-C Chou, Y-Y Kuo, C-Y Liu, L-I Lin, M-H Tseng, Y-C Chiang, M-C Liu, C-W Liu, J-L Tang, M Yao, C-C Li, S-Y Huang, B-S Ko, S-C Hsu, C-Y Chen, C-T Lin, S-J Wu, W Tsay, Y-C Chen, H-F Tien

ABSTRACT

The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this mutation during the clinical course remains unclear. In this study, TP53 mutations were identified in 7% of 500 patients with de novo AML and 58.8% of patients with CK. TP53 mutations were closely associated with older age, lower white blood cell (WBC) and platelet counts, FAB M6 subtype, unfavorable-risk cytogenetics and CK, but negatively associated with NPM1 mutation, FLT3/ITD and DNMT3A mutation. Multivariate analysis demonstrated that TP53 mutation was an independent poor prognostic factor for overall survival and disease-free survival among the total cohort and the subgroup of patients with CK. A scoring system incorporating TP53 mutation and nine other prognostic factors, including age, WBC counts, cytogenetics and gene mutations, into survival analysis proved to be very useful to stratify AML patients. Sequential study of 420 samples showed that TP53 mutations were stable during AML evolution, whereas the mutation was acquired only in 1 of the 126 TP53 wild-type patients when therapy-related AML originated from different clone emerged. In conclusion, TP53 mutations are associated with distinct clinic-biological features and poor prognosis in de novo AML patients and are rather stable during disease progression. More... »

PAGES

e331

References to SciGraph publications

  • 2008-08. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype in LEUKEMIA
  • 2008-05. Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD in LEUKEMIA
  • 2007-04. TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes in ONCOGENE
  • 1986-03. Localization of gene for human p53 tumour antigen to band 17p13 in NATURE
  • 1989-12. Mutations in the p53 gene occur in diverse human tumour types in NATURE
  • 2006-06. Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome in LEUKEMIA
  • 2000-11. Surfing the p53 network in NATURE
  • 2014-01. Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia in LEUKEMIA
  • 2015-02. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia in NATURE
  • 2009-01. Recent advances in p53 research: an interdisciplinary perspective in CANCER GENE THERAPY
  • 2009-01. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis in LEUKEMIA
  • 2014-01. Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome in BLOOD CANCER JOURNAL
  • 2002-02. Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23 in LEUKEMIA
  • 2006-11. Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia in LEUKEMIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bcj.2015.59

    DOI

    http://dx.doi.org/10.1038/bcj.2015.59

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001936927

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26230955


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