Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-01

AUTHORS

T-C Chen, H-A Hou, W-C Chou, J-L Tang, Y-Y Kuo, C-Y Chen, M-H Tseng, C-F Huang, Y-J Lai, Y-C Chiang, F-Y Lee, M-C Liu, C-W Liu, C-Y Liu, M Yao, S-Y Huang, B-S Ko, S-C Hsu, S-J Wu, W Tsay, Y-C Chen, H-F Tien

ABSTRACT

Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in patients with myelodysplastic syndrome (MDS), but the interaction of this mutation with other genetic alterations and its dynamic changes during disease progression remain to be determined. In this study, ASXL1 mutations were identified in 106 (22.7%) of the 466 patients with primary MDS based on the French-American-British (FAB) classification and 62 (17.1%) of the 362 patients based on the World Health Organization (WHO) classification. ASXL1 mutation was closely associated with trisomy 8 and mutations of RUNX1, EZH2, IDH, NRAS, JAK2, SETBP1 and SRSF2, but was negatively associated with SF3B1 mutation. Most ASXL1-mutated patients (85%) had concurrent other gene mutations at diagnosis. ASXL1 mutation was an independent poor prognostic factor for survival. Sequential studies showed that the original ASXL1 mutation remained unchanged at disease progression in all 32 ASXL1-mutated patients but were frequently accompanied with acquisition of mutations of other genes, including RUNX1, NRAS, KRAS, SF3B1, SETBP1 and chromosomal evolution. On the other side, among the 80 ASXL1-wild patients, only one acquired ASXL1 mutation at leukemia transformation. In conclusion, ASXL1 mutations in association with other genetic alterations may have a role in the development of MDS but contribute little to disease progression. More... »

PAGES

e177

References to SciGraph publications

  • 2011-02. The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia in LEUKEMIA
  • 2010-01. Myelodysplastic syndromes: lost between two states? in LEUKEMIA
  • 2006-06. Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome in LEUKEMIA
  • 2010-08. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders in NATURE GENETICS
  • 2006-07. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2 in NATURE
  • 2011-10. Frequent pathway mutations of splicing machinery in myelodysplasia in NATURE
  • 2010-05. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB in NATURE
  • 2012-04. TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms in ANNALS OF HEMATOLOGY
  • 2011-07. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms in LEUKEMIA
  • 2010-12. Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias in BMC CANCER
  • 2001-07. Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases in NATURE
  • 2010-05. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia in LEUKEMIA
  • 2002-02. Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23 in LEUKEMIA
  • 2012-01. Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bcj.2013.74

    DOI

    http://dx.doi.org/10.1038/bcj.2013.74

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037436861

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24442206


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "T-C", 
            "id": "sg:person.01033400512.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033400512.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "1] Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hou", 
            "givenName": "H-A", 
            "id": "sg:person.0676735543.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676735543.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "1] Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chou", 
            "givenName": "W-C", 
            "id": "sg:person.01061277343.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061277343.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "J-L", 
            "id": "sg:person.011336406464.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011336406464.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University", 
              "id": "https://www.grid.ac/institutes/grid.19188.39", 
              "name": [
                "Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuo", 
            "givenName": "Y-Y", 
            "id": "sg:person.0642315556.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642315556.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "C-Y", 
            "id": "sg:person.01175525743.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175525743.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tseng", 
            "givenName": "M-H", 
            "id": "sg:person.01072772556.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072772556.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "C-F", 
            "id": "sg:person.01365321011.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365321011.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lai", 
            "givenName": "Y-J", 
            "id": "sg:person.01024657356.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024657356.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chiang", 
            "givenName": "Y-C", 
            "id": "sg:person.0634463443.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634463443.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Department of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "F-Y", 
            "id": "sg:person.010252621722.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010252621722.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Department of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "M-C", 
            "id": "sg:person.01202757211.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202757211.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "C-W", 
            "id": "sg:person.01251072411.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251072411.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taipei University of Nursing and Health Science", 
              "id": "https://www.grid.ac/institutes/grid.412146.4", 
              "name": [
                "Biostatistics Consulting Laboratory, Department of Nursing, National Taipei University of Nursing and Health Science, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "C-Y", 
            "id": "sg:person.01013164143.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013164143.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yao", 
            "givenName": "M", 
            "id": "sg:person.0646462116.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646462116.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "S-Y", 
            "id": "sg:person.016600345354.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016600345354.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ko", 
            "givenName": "B-S", 
            "id": "sg:person.01234635206.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234635206.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hsu", 
            "givenName": "S-C", 
            "id": "sg:person.0603450016.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603450016.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "S-J", 
            "id": "sg:person.01363730643.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363730643.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsay", 
            "givenName": "W", 
            "id": "sg:person.0721210172.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721210172.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "1] Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Y-C", 
            "id": "sg:person.0706437743.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706437743.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Taiwan University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412094.a", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tien", 
            "givenName": "H-F", 
            "id": "sg:person.013177614042.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013177614042.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1200/jco.2010.31.1175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000898805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.06.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002480936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.06.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002480936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-011-1001-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004908166", 
              "https://doi.org/10.1007/s12185-011-1001-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20131141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004968521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-4316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006184192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35085610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007333886", 
              "https://doi.org/10.1038/35085610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35085610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007333886", 
              "https://doi.org/10.1038/35085610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminhematol.2007.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007806086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2010.08381.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008022542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2010.08381.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008022542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008245757", 
              "https://doi.org/10.1038/nature10496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci70739", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008553260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajh.23611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008933256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-12-259390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010905659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.med.56.082103.104704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011681849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2013-05-500272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012041006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2007.06811.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013214251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-011-1330-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013637963", 
              "https://doi.org/10.1007/s00277-011-1330-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015343459", 
              "https://doi.org/10.1186/1471-2407-10-401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-05-283291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020362185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021168280", 
              "https://doi.org/10.1038/nature08966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021250307", 
              "https://doi.org/10.1038/sj.leu.2404190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021250307", 
              "https://doi.org/10.1038/sj.leu.2404190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023378568", 
              "https://doi.org/10.1038/nature04814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023378568", 
              "https://doi.org/10.1038/nature04814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023378568", 
              "https://doi.org/10.1038/nature04814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1013343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027110305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031090846", 
              "https://doi.org/10.1038/leu.2010.20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-4608(95)00084-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032344571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2005.10.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034530423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-05-223784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035378560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-05-223784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035378560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2009.07697.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036319854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2009.07697.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036319854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-3783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036405420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.33.4938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036660359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2011.58", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036721490", 
              "https://doi.org/10.1038/leu.2011.58"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-03-420489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042747172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043515724", 
              "https://doi.org/10.1038/leu.2010.267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-02-412296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044042486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044335412", 
              "https://doi.org/10.1038/sj.leu.2402352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044335412", 
              "https://doi.org/10.1038/sj.leu.2402352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2009.157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045060425", 
              "https://doi.org/10.1038/leu.2009.157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045969373", 
              "https://doi.org/10.1038/ng.621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjh.12435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047420888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-11-253070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050076672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/asheducation-2011.1.543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050324549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-07-369934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051641156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1221711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062466650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1221711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062466650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083056512", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-01", 
        "datePublishedReg": "2014-01-01", 
        "description": "Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in patients with myelodysplastic syndrome (MDS), but the interaction of this mutation with other genetic alterations and its dynamic changes during disease progression remain to be determined. In this study, ASXL1 mutations were identified in 106 (22.7%) of the 466 patients with primary MDS based on the French-American-British (FAB) classification and 62 (17.1%) of the 362 patients based on the World Health Organization (WHO) classification. ASXL1 mutation was closely associated with trisomy 8 and mutations of RUNX1, EZH2, IDH, NRAS, JAK2, SETBP1 and SRSF2, but was negatively associated with SF3B1 mutation. Most ASXL1-mutated patients (85%) had concurrent other gene mutations at diagnosis. ASXL1 mutation was an independent poor prognostic factor for survival. Sequential studies showed that the original ASXL1 mutation remained unchanged at disease progression in all 32 ASXL1-mutated patients but were frequently accompanied with acquisition of mutations of other genes, including RUNX1, NRAS, KRAS, SF3B1, SETBP1 and chromosomal evolution. On the other side, among the 80 ASXL1-wild patients, only one acquired ASXL1 mutation at leukemia transformation. In conclusion, ASXL1 mutations in association with other genetic alterations may have a role in the development of MDS but contribute little to disease progression. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/bcj.2013.74", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045682", 
            "issn": [
              "2044-5385"
            ], 
            "name": "Blood Cancer Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "name": "Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome", 
        "pagination": "e177", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bcj.2013.74"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037436861"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b25559e9fc4756311c258ca974fe057ba9fc198e2fb71ec6215e52179f8d3e15"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101568469"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24442206"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bcj.2013.74", 
          "https://app.dimensions.ai/details/publication/pub.1037436861"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-16T06:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106840_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/bcj201374"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bcj.2013.74'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bcj.2013.74'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bcj.2013.74'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bcj.2013.74'


     

    This table displays all metadata directly associated to this object as RDF triples.

    364 TRIPLES      21 PREDICATES      71 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bcj.2013.74 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N4adcf6c99c3c4e529ece4806989d1748
    4 schema:citation sg:pub.10.1007/s00277-011-1330-0
    5 sg:pub.10.1007/s12185-011-1001-x
    6 sg:pub.10.1038/35085610
    7 sg:pub.10.1038/leu.2009.157
    8 sg:pub.10.1038/leu.2010.20
    9 sg:pub.10.1038/leu.2010.267
    10 sg:pub.10.1038/leu.2011.58
    11 sg:pub.10.1038/nature04814
    12 sg:pub.10.1038/nature08966
    13 sg:pub.10.1038/nature10496
    14 sg:pub.10.1038/ng.621
    15 sg:pub.10.1038/sj.leu.2402352
    16 sg:pub.10.1038/sj.leu.2404190
    17 sg:pub.10.1186/1471-2407-10-401
    18 https://app.dimensions.ai/details/publication/pub.1083056512
    19 https://doi.org/10.1002/ajh.23611
    20 https://doi.org/10.1016/0165-4608(95)00084-4
    21 https://doi.org/10.1016/j.ccr.2012.06.032
    22 https://doi.org/10.1016/j.gene.2005.10.033
    23 https://doi.org/10.1053/j.seminhematol.2007.11.006
    24 https://doi.org/10.1056/nejmoa1013343
    25 https://doi.org/10.1084/jem.20131141
    26 https://doi.org/10.1111/bjh.12435
    27 https://doi.org/10.1111/j.1365-2141.2007.06811.x
    28 https://doi.org/10.1111/j.1365-2141.2009.07697.x
    29 https://doi.org/10.1111/j.1365-2141.2010.08381.x
    30 https://doi.org/10.1126/science.1221711
    31 https://doi.org/10.1146/annurev.med.56.082103.104704
    32 https://doi.org/10.1158/0008-5472.can-05-4316
    33 https://doi.org/10.1158/0008-5472.can-09-3783
    34 https://doi.org/10.1172/jci70739
    35 https://doi.org/10.1182/asheducation-2011.1.543
    36 https://doi.org/10.1182/blood-2009-05-223784
    37 https://doi.org/10.1182/blood-2009-11-253070
    38 https://doi.org/10.1182/blood-2009-12-259390
    39 https://doi.org/10.1182/blood-2010-05-283291
    40 https://doi.org/10.1182/blood-2011-07-369934
    41 https://doi.org/10.1182/blood-2012-02-412296
    42 https://doi.org/10.1182/blood-2012-03-420489
    43 https://doi.org/10.1182/blood-2013-05-500272
    44 https://doi.org/10.1200/jco.2010.31.1175
    45 https://doi.org/10.1200/jco.2010.33.4938
    46 schema:datePublished 2014-01
    47 schema:datePublishedReg 2014-01-01
    48 schema:description Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in patients with myelodysplastic syndrome (MDS), but the interaction of this mutation with other genetic alterations and its dynamic changes during disease progression remain to be determined. In this study, ASXL1 mutations were identified in 106 (22.7%) of the 466 patients with primary MDS based on the French-American-British (FAB) classification and 62 (17.1%) of the 362 patients based on the World Health Organization (WHO) classification. ASXL1 mutation was closely associated with trisomy 8 and mutations of RUNX1, EZH2, IDH, NRAS, JAK2, SETBP1 and SRSF2, but was negatively associated with SF3B1 mutation. Most ASXL1-mutated patients (85%) had concurrent other gene mutations at diagnosis. ASXL1 mutation was an independent poor prognostic factor for survival. Sequential studies showed that the original ASXL1 mutation remained unchanged at disease progression in all 32 ASXL1-mutated patients but were frequently accompanied with acquisition of mutations of other genes, including RUNX1, NRAS, KRAS, SF3B1, SETBP1 and chromosomal evolution. On the other side, among the 80 ASXL1-wild patients, only one acquired ASXL1 mutation at leukemia transformation. In conclusion, ASXL1 mutations in association with other genetic alterations may have a role in the development of MDS but contribute little to disease progression.
    49 schema:genre research_article
    50 schema:inLanguage en
    51 schema:isAccessibleForFree true
    52 schema:isPartOf N4a73e47087c9467db9e764d651e77e67
    53 N94c46797add24ea2958fcd9db783cd2c
    54 sg:journal.1045682
    55 schema:name Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome
    56 schema:pagination e177
    57 schema:productId N697f84d2024a46e093a18ee5d979be9d
    58 N89472868c6a64662ad351c0301387e7e
    59 N8d34874360554510a26d0207058f1337
    60 N920792612257424795134a209b0bdb38
    61 N9fc7e764114b4ca287c6e157b7621921
    62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037436861
    63 https://doi.org/10.1038/bcj.2013.74
    64 schema:sdDatePublished 2019-04-16T06:25
    65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    66 schema:sdPublisher N0235ec59d1de4882950f482f035386db
    67 schema:url https://www.nature.com/articles/bcj201374
    68 sgo:license sg:explorer/license/
    69 sgo:sdDataset articles
    70 rdf:type schema:ScholarlyArticle
    71 N0235ec59d1de4882950f482f035386db schema:name Springer Nature - SN SciGraph project
    72 rdf:type schema:Organization
    73 N0ee08c9fc3e24bed94e79c18beb11e79 rdf:first sg:person.01175525743.45
    74 rdf:rest Na2681d68320c4705a3e09971322b4914
    75 N104dbae0cb0249db9bab260420ebd17f rdf:first sg:person.010252621722.95
    76 rdf:rest Naabd35feb8e54f55a74a0e4c37b05d98
    77 N1882b8c0fff54bceb8422ebfc828b16f rdf:first sg:person.0634463443.36
    78 rdf:rest N104dbae0cb0249db9bab260420ebd17f
    79 N27bb92c1a0de45ddbfab955fe0be5284 rdf:first sg:person.011336406464.70
    80 rdf:rest Nefb88a20794f4309b1cede19fe480b95
    81 N4a73e47087c9467db9e764d651e77e67 schema:issueNumber 1
    82 rdf:type schema:PublicationIssue
    83 N4adcf6c99c3c4e529ece4806989d1748 rdf:first sg:person.01033400512.68
    84 rdf:rest N5158effcc82d4b2989112f4b4efc1f74
    85 N5158effcc82d4b2989112f4b4efc1f74 rdf:first sg:person.0676735543.78
    86 rdf:rest Nfcf09d1b5cd3424f9ba601fb05171373
    87 N571378424cc54821ad071f4c21f9b5b6 rdf:first sg:person.01251072411.69
    88 rdf:rest Nb820ec3a067d4a8b8ed7d0cc20bcea4c
    89 N57d188677d0b419bb6055e9b18ccec2b rdf:first sg:person.01024657356.21
    90 rdf:rest N1882b8c0fff54bceb8422ebfc828b16f
    91 N697f84d2024a46e093a18ee5d979be9d schema:name dimensions_id
    92 schema:value pub.1037436861
    93 rdf:type schema:PropertyValue
    94 N6aa152536ac44ba58ab9081bfdc51ff0 rdf:first sg:person.0721210172.02
    95 rdf:rest Nadc9d13849294c319fd89ab4b0808c91
    96 N7090045215314991a67c255a1d27adbe rdf:first sg:person.013177614042.37
    97 rdf:rest rdf:nil
    98 N83b26b41cd9b42d791f62eb59abbf287 rdf:first sg:person.01234635206.36
    99 rdf:rest Naaa14aa7542540ac8797ffa69fa3d57d
    100 N89472868c6a64662ad351c0301387e7e schema:name readcube_id
    101 schema:value b25559e9fc4756311c258ca974fe057ba9fc198e2fb71ec6215e52179f8d3e15
    102 rdf:type schema:PropertyValue
    103 N8d34874360554510a26d0207058f1337 schema:name pubmed_id
    104 schema:value 24442206
    105 rdf:type schema:PropertyValue
    106 N920792612257424795134a209b0bdb38 schema:name doi
    107 schema:value 10.1038/bcj.2013.74
    108 rdf:type schema:PropertyValue
    109 N94c46797add24ea2958fcd9db783cd2c schema:volumeNumber 4
    110 rdf:type schema:PublicationVolume
    111 N9fc7e764114b4ca287c6e157b7621921 schema:name nlm_unique_id
    112 schema:value 101568469
    113 rdf:type schema:PropertyValue
    114 Na2681d68320c4705a3e09971322b4914 rdf:first sg:person.01072772556.29
    115 rdf:rest Nf0f46b4d46634f92a7f01e73cc78d0fb
    116 Naaa14aa7542540ac8797ffa69fa3d57d rdf:first sg:person.0603450016.49
    117 rdf:rest Nc4a292761bdf427696c422a8c04f7003
    118 Naabd35feb8e54f55a74a0e4c37b05d98 rdf:first sg:person.01202757211.36
    119 rdf:rest N571378424cc54821ad071f4c21f9b5b6
    120 Nadc9d13849294c319fd89ab4b0808c91 rdf:first sg:person.0706437743.57
    121 rdf:rest N7090045215314991a67c255a1d27adbe
    122 Nb5b7c4150462483694d404599c9b582b rdf:first sg:person.0646462116.10
    123 rdf:rest Nb875aebb6cfb4512b213ec99f292bf6e
    124 Nb820ec3a067d4a8b8ed7d0cc20bcea4c rdf:first sg:person.01013164143.73
    125 rdf:rest Nb5b7c4150462483694d404599c9b582b
    126 Nb875aebb6cfb4512b213ec99f292bf6e rdf:first sg:person.016600345354.31
    127 rdf:rest N83b26b41cd9b42d791f62eb59abbf287
    128 Nc4a292761bdf427696c422a8c04f7003 rdf:first sg:person.01363730643.29
    129 rdf:rest N6aa152536ac44ba58ab9081bfdc51ff0
    130 Nefb88a20794f4309b1cede19fe480b95 rdf:first sg:person.0642315556.00
    131 rdf:rest N0ee08c9fc3e24bed94e79c18beb11e79
    132 Nf0f46b4d46634f92a7f01e73cc78d0fb rdf:first sg:person.01365321011.16
    133 rdf:rest N57d188677d0b419bb6055e9b18ccec2b
    134 Nfcf09d1b5cd3424f9ba601fb05171373 rdf:first sg:person.01061277343.50
    135 rdf:rest N27bb92c1a0de45ddbfab955fe0be5284
    136 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    137 schema:name Biological Sciences
    138 rdf:type schema:DefinedTerm
    139 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    140 schema:name Genetics
    141 rdf:type schema:DefinedTerm
    142 sg:journal.1045682 schema:issn 2044-5385
    143 schema:name Blood Cancer Journal
    144 rdf:type schema:Periodical
    145 sg:person.01013164143.73 schema:affiliation https://www.grid.ac/institutes/grid.412146.4
    146 schema:familyName Liu
    147 schema:givenName C-Y
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013164143.73
    149 rdf:type schema:Person
    150 sg:person.01024657356.21 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    151 schema:familyName Lai
    152 schema:givenName Y-J
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024657356.21
    154 rdf:type schema:Person
    155 sg:person.010252621722.95 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    156 schema:familyName Lee
    157 schema:givenName F-Y
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010252621722.95
    159 rdf:type schema:Person
    160 sg:person.01033400512.68 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    161 schema:familyName Chen
    162 schema:givenName T-C
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033400512.68
    164 rdf:type schema:Person
    165 sg:person.01061277343.50 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    166 schema:familyName Chou
    167 schema:givenName W-C
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061277343.50
    169 rdf:type schema:Person
    170 sg:person.01072772556.29 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    171 schema:familyName Tseng
    172 schema:givenName M-H
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072772556.29
    174 rdf:type schema:Person
    175 sg:person.011336406464.70 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    176 schema:familyName Tang
    177 schema:givenName J-L
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011336406464.70
    179 rdf:type schema:Person
    180 sg:person.01175525743.45 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    181 schema:familyName Chen
    182 schema:givenName C-Y
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175525743.45
    184 rdf:type schema:Person
    185 sg:person.01202757211.36 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    186 schema:familyName Liu
    187 schema:givenName M-C
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202757211.36
    189 rdf:type schema:Person
    190 sg:person.01234635206.36 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    191 schema:familyName Ko
    192 schema:givenName B-S
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234635206.36
    194 rdf:type schema:Person
    195 sg:person.01251072411.69 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    196 schema:familyName Liu
    197 schema:givenName C-W
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251072411.69
    199 rdf:type schema:Person
    200 sg:person.013177614042.37 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    201 schema:familyName Tien
    202 schema:givenName H-F
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013177614042.37
    204 rdf:type schema:Person
    205 sg:person.01363730643.29 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    206 schema:familyName Wu
    207 schema:givenName S-J
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363730643.29
    209 rdf:type schema:Person
    210 sg:person.01365321011.16 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    211 schema:familyName Huang
    212 schema:givenName C-F
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365321011.16
    214 rdf:type schema:Person
    215 sg:person.016600345354.31 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    216 schema:familyName Huang
    217 schema:givenName S-Y
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016600345354.31
    219 rdf:type schema:Person
    220 sg:person.0603450016.49 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    221 schema:familyName Hsu
    222 schema:givenName S-C
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603450016.49
    224 rdf:type schema:Person
    225 sg:person.0634463443.36 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    226 schema:familyName Chiang
    227 schema:givenName Y-C
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634463443.36
    229 rdf:type schema:Person
    230 sg:person.0642315556.00 schema:affiliation https://www.grid.ac/institutes/grid.19188.39
    231 schema:familyName Kuo
    232 schema:givenName Y-Y
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642315556.00
    234 rdf:type schema:Person
    235 sg:person.0646462116.10 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    236 schema:familyName Yao
    237 schema:givenName M
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646462116.10
    239 rdf:type schema:Person
    240 sg:person.0676735543.78 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    241 schema:familyName Hou
    242 schema:givenName H-A
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676735543.78
    244 rdf:type schema:Person
    245 sg:person.0706437743.57 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    246 schema:familyName Chen
    247 schema:givenName Y-C
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706437743.57
    249 rdf:type schema:Person
    250 sg:person.0721210172.02 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
    251 schema:familyName Tsay
    252 schema:givenName W
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721210172.02
    254 rdf:type schema:Person
    255 sg:pub.10.1007/s00277-011-1330-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013637963
    256 https://doi.org/10.1007/s00277-011-1330-0
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1007/s12185-011-1001-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004908166
    259 https://doi.org/10.1007/s12185-011-1001-x
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/35085610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007333886
    262 https://doi.org/10.1038/35085610
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/leu.2009.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045060425
    265 https://doi.org/10.1038/leu.2009.157
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/leu.2010.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031090846
    268 https://doi.org/10.1038/leu.2010.20
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/leu.2010.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043515724
    271 https://doi.org/10.1038/leu.2010.267
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/leu.2011.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036721490
    274 https://doi.org/10.1038/leu.2011.58
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/nature04814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023378568
    277 https://doi.org/10.1038/nature04814
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nature08966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021168280
    280 https://doi.org/10.1038/nature08966
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nature10496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008245757
    283 https://doi.org/10.1038/nature10496
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/ng.621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045969373
    286 https://doi.org/10.1038/ng.621
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/sj.leu.2402352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044335412
    289 https://doi.org/10.1038/sj.leu.2402352
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/sj.leu.2404190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021250307
    292 https://doi.org/10.1038/sj.leu.2404190
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1186/1471-2407-10-401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015343459
    295 https://doi.org/10.1186/1471-2407-10-401
    296 rdf:type schema:CreativeWork
    297 https://app.dimensions.ai/details/publication/pub.1083056512 schema:CreativeWork
    298 https://doi.org/10.1002/ajh.23611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008933256
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/0165-4608(95)00084-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032344571
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.ccr.2012.06.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002480936
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.gene.2005.10.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034530423
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1053/j.seminhematol.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007806086
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1056/nejmoa1013343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027110305
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1084/jem.20131141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004968521
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1111/bjh.12435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047420888
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1111/j.1365-2141.2007.06811.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013214251
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1111/j.1365-2141.2009.07697.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036319854
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1111/j.1365-2141.2010.08381.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008022542
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1126/science.1221711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062466650
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1146/annurev.med.56.082103.104704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011681849
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1158/0008-5472.can-05-4316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006184192
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1158/0008-5472.can-09-3783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036405420
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1172/jci70739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008553260
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1182/asheducation-2011.1.543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050324549
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1182/blood-2009-05-223784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035378560
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1182/blood-2009-11-253070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050076672
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1182/blood-2009-12-259390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010905659
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1182/blood-2010-05-283291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020362185
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1182/blood-2011-07-369934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051641156
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1182/blood-2012-02-412296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044042486
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1182/blood-2012-03-420489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042747172
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1182/blood-2013-05-500272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012041006
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1200/jco.2010.31.1175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000898805
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1200/jco.2010.33.4938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036660359
    351 rdf:type schema:CreativeWork
    352 https://www.grid.ac/institutes/grid.19188.39 schema:alternateName National Taiwan University
    353 schema:name Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan.
    354 rdf:type schema:Organization
    355 https://www.grid.ac/institutes/grid.412094.a schema:alternateName National Taiwan University Hospital
    356 schema:name 1] Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
    357 1] Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
    358 Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
    359 Department of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
    360 Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
    361 rdf:type schema:Organization
    362 https://www.grid.ac/institutes/grid.412146.4 schema:alternateName National Taipei University of Nursing and Health Science
    363 schema:name Biostatistics Consulting Laboratory, Department of Nursing, National Taipei University of Nursing and Health Science, Taipei, Taiwan.
    364 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...