Cancer-testis antigen expression and immunogenicity in AL amyloidosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-09

AUTHORS

M A Rosenzweig, H Landau, D Seldin, C O'Hara, S Girnius, N Hanson, D Frosina, C Sedrak, M Arcila, R L Comenzo, S Giralt, S Gnjatic, A A Jungbluth, G Koehne

ABSTRACT

Light-chain amyloidosis (AL) is a plasma cell dyscrasia closely related to multiple myeloma. In multiple myeloma, the cancer-testis antigens (CTAs) CT7 (MAGE-C1), CT10 (MAGE-C2) and MAGE-A CTAs are expressed in up to 80% of cases. In this study, we investigated the expression and immunogenicity of several CTAs in patients with AL amyloidosis in a total of 38 bone marrow specimens by employing standard immunohistochemistry techniques on paraffin-embedded archival tissues. Plasma samples from 35 patients (27 with matched bone marrow samples) were also analyzed by ELISA for sero reactivity to a group of full-length CTA proteins. CT7 was present in 25/38 (66%) while CT10 was demonstrated in 3/38 and GAGE in 1/38 AL amyloid cases. The expression pattern was mostly focal. There were no significant differences with regard to organ involvement, response to treatment, or prognosis in CTA positive compared to negative cases. None of the specimens showed spontaneous humoral immunity to CT7, but sero reactivity was observed in individual patients to other CTAs. This study identifies CT7 as the prevalent CTA in plasma cells of patients with AL amyloidosis. Further analyses determining the biology of CTAs in AL amyloidosis and their value as potential targets for immunotherapy are warranted. More... »

PAGES

e90

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bcj.2012.32

DOI

http://dx.doi.org/10.1038/bcj.2012.32

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019169106

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22983433


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bcj.2012.32'

Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bcj.2012.32'


 

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