Topical delivery of silymarin constituents via the skin route View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01

AUTHORS

Chi-feng Hung, Yin-ku Lin, Li-wen Zhang, Ching-hsien Chang, Jia-you Fang

ABSTRACT

AIM: Silibinin (SB), silydianin (SD), and silychristin (SC) are components of silymarin. These compounds can be used to protect the skin from oxidative stress induced by ultraviolet (UV) irradiation and treat it. To this end, the absorption of silymarin constituents via the skin was examined in the present report. METHODS: Transport of SB, SD, and SC under the same thermodynamic activity through and into the skin and the effects of pH were studied in vitro using a Franz diffusion assembly. RESULTS: The lipophilicity increased in the order of SC More... »

PAGES

aps2009186

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URI

http://scigraph.springernature.com/pub.10.1038/aps.2009.186

DOI

http://dx.doi.org/10.1038/aps.2009.186

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008377764

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20023692


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