Ontology type: schema:ScholarlyArticle Open Access: True
2016-04
AUTHORSMarios Hadjivassiliou, Dasappaiah G Rao, Richard A Grìnewald, Daniel P Aeschlimann, Ptolemaios G Sarrigiannis, Nigel Hoggard, Pascale Aeschlimann, Peter D Mooney, David S Sanders
ABSTRACTOBJECTIVES: Non-coeliac gluten sensitivity (NCGS) refers to patients with primarily gastrointestinal symptoms without enteropathy that symptomatically benefit from gluten-free diet (GFD). Little is known about its pathophysiology, propensity to neurological manifestations, and if these differ from patients with coeliac disease (CD). We investigated the clinical and immunological characteristics of patients presenting with neurological manifestations with CD and those with NCGS. METHODS: We compared clinical, neurophysiological, and imaging data of patients with CD and NCGS presenting with neurological dysfunction assessed and followed up regularly over a period of 20 years. RESULTS: Out of 700 patients, 562 were included. Exclusion criteria included no bowel biopsy to confirm CD, no HLA type available, and failure to adhere to GFD. All patients presented with neurological dysfunction and had circulating anti-gliadin antibodies. Out of 562 patients, 228 (41%) had evidence of enteropathy (Group 1, CD) and 334 (59%) did not (Group 2, NCGS). The most common neurological manifestations were cerebellar ataxia, peripheral neuropathy, and encephalopathy. There was a greater proportion of patients with encephalopathy in Group 1 and with a greater proportion of neuropathy in Group 2. The severity of ataxia did not differ between the two groups. Patients in Group 1 had more severe neuropathy. All patients from both groups responded to gluten-free diet. Anti-tissue transglutaminase (TG2) antibodies were found in 91% of patients in Group 1 and in 29% of patients in Group 2. Comparison between those patients in Group 2 with HLA-DQ2/DQ8 and those without as well as those with positive TG2 compared with those with negative TG2 antibodies identified no differences within these subgroups. Serological positivity for TG6 antibodies was similar in the two groups (67 and 60%). CONCLUSIONS: The neurological manifestations of CD and NCGS are similar and equally responsive to a GFD suggestive of common pathophysiological mechanisms. More... »
PAGES561
http://scigraph.springernature.com/pub.10.1038/ajg.2015.434
DOIhttp://dx.doi.org/10.1038/ajg.2015.434
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1013686058
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26832652
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Celiac Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diet, Gluten-Free",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glutens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nervous System Diseases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Academic Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Hadjivassiliou",
"givenName": "Marios",
"id": "sg:person.01354423242.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354423242.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Academic Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Rao",
"givenName": "Dasappaiah G",
"id": "sg:person.0752446006.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752446006.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Academic Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Gr\u00ecnewald",
"givenName": "Richard A",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiff University",
"id": "https://www.grid.ac/institutes/grid.5600.3",
"name": [
"Matrix Biology and Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, Wales, UK"
],
"type": "Organization"
},
"familyName": "Aeschlimann",
"givenName": "Daniel P",
"id": "sg:person.01007061523.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007061523.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Academic Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Sarrigiannis",
"givenName": "Ptolemaios G",
"id": "sg:person.01132771412.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132771412.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Academic Department of Neuroradiology, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Hoggard",
"givenName": "Nigel",
"id": "sg:person.0610025364.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610025364.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Academic Department of Neuroradiology, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Aeschlimann",
"givenName": "Pascale",
"id": "sg:person.01107523472.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107523472.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Mooney",
"givenName": "Peter D",
"id": "sg:person.01126403774.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126403774.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Hallamshire Hospital",
"id": "https://www.grid.ac/institutes/grid.416126.6",
"name": [
"Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK"
],
"type": "Organization"
},
"familyName": "Sanders",
"givenName": "David S",
"id": "sg:person.016071637312.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016071637312.37"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1136/gutjnl-2015-309757",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002051428"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/mus.20642",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004125477"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(96)90540-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004693875"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20102660",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005044728"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/2053-8871-1-11",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010244213",
"https://doi.org/10.1186/2053-8871-1-11"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0009698",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012024760"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ana.21450",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014376929"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1741-7015-12-85",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019863964",
"https://doi.org/10.1186/1741-7015-12-85"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1003273",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022065511"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gutjnl-2011-301346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023522803"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(98)05342-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024755673"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000260087",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027648091"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00726-010-0554-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030848377",
"https://doi.org/10.1007/s00726-010-0554-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00726-010-0554-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030848377",
"https://doi.org/10.1007/s00726-010-0554-y"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jnnp.74.9.1221",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033498154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/nu7064966",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033753388"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1741-7015-10-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035374109",
"https://doi.org/10.1186/1741-7015-10-13"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ajg.2013.91",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037017448",
"https://doi.org/10.1038/ajg.2013.91"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20011299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041710962"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2015.05.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044678525"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrgastro.2015.107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048614130",
"https://doi.org/10.1038/nrgastro.2015.107"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jnnp.2004.049809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049558864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000196480.55601.3a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347809"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000196480.55601.3a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347809"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000196480.55601.3a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347809"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000196480.55601.3a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347809"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e3182919070",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064357733"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e3182919070",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064357733"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e3182919070",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064357733"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078729631",
"type": "CreativeWork"
}
],
"datePublished": "2016-04",
"datePublishedReg": "2016-04-01",
"description": "OBJECTIVES: Non-coeliac gluten sensitivity (NCGS) refers to patients with primarily gastrointestinal symptoms without enteropathy that symptomatically benefit from gluten-free diet (GFD). Little is known about its pathophysiology, propensity to neurological manifestations, and if these differ from patients with coeliac disease (CD). We investigated the clinical and immunological characteristics of patients presenting with neurological manifestations with CD and those with NCGS.\nMETHODS: We compared clinical, neurophysiological, and imaging data of patients with CD and NCGS presenting with neurological dysfunction assessed and followed up regularly over a period of 20 years.\nRESULTS: Out of 700 patients, 562 were included. Exclusion criteria included no bowel biopsy to confirm CD, no HLA type available, and failure to adhere to GFD. All patients presented with neurological dysfunction and had circulating anti-gliadin antibodies. Out of 562 patients, 228 (41%) had evidence of enteropathy (Group 1, CD) and 334 (59%) did not (Group 2, NCGS). The most common neurological manifestations were cerebellar ataxia, peripheral neuropathy, and encephalopathy. There was a greater proportion of patients with encephalopathy in Group 1 and with a greater proportion of neuropathy in Group 2. The severity of ataxia did not differ between the two groups. Patients in Group 1 had more severe neuropathy. All patients from both groups responded to gluten-free diet. Anti-tissue transglutaminase (TG2) antibodies were found in 91% of patients in Group 1 and in 29% of patients in Group 2. Comparison between those patients in Group 2 with HLA-DQ2/DQ8 and those without as well as those with positive TG2 compared with those with negative TG2 antibodies identified no differences within these subgroups. Serological positivity for TG6 antibodies was similar in the two groups (67 and 60%).\nCONCLUSIONS: The neurological manifestations of CD and NCGS are similar and equally responsive to a GFD suggestive of common pathophysiological mechanisms.",
"genre": "research_article",
"id": "sg:pub.10.1038/ajg.2015.434",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1019809",
"issn": [
"0002-9270",
"1572-0241"
],
"name": "The American Journal of Gastroenterology",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "111"
}
],
"name": "Neurological Dysfunction in Coeliac Disease and Non-Coeliac Gluten Sensitivity",
"pagination": "561",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"4132a6ba86440845a004a58bf5af93da7bedeb756a418b0775cf432bc0542935"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26832652"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0421030"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ajg.2015.434"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1013686058"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ajg.2015.434",
"https://app.dimensions.ai/details/publication/pub.1013686058"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:44",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70068_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/ajg2015434"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ajg.2015.434'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ajg.2015.434'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ajg.2015.434'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ajg.2015.434'
This table displays all metadata directly associated to this object as RDF triples.
266 TRIPLES
21 PREDICATES
68 URIs
36 LITERALS
24 BLANK NODES