Abnormal Structure and Function of the Esophagogastric Junction and Proximal Stomach in Gastroesophageal Reflux Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-03-04

AUTHORS

Jelena Curcic, Shammodip Roy, Alexandra Schwizer, Elad Kaufman, Zsofia Forras-Kaufman, Dieter Menne, Geoffrey S Hebbard, Reto Treier, Peter Boesiger, Andreas Steingoetter, Michael Fried, Werner Schwizer, Anupam Pal, Mark Fox

ABSTRACT

OBJECTIVES: This study applies concurrent magnetic resonance imaging (MRI) and high-resolution manometry (HRM) to test the hypothesis that structural factors involved in reflux protection, in particular, the acute insertion angle of the esophagus into the stomach, are impaired in gastroesophageal reflux disease (GERD) patients. METHODS: A total of 24 healthy volunteers and 24 patients with mild-moderate GERD ingested a test meal. Three-dimensional models of the esophagogastric junction (EGJ) were reconstructed from MRI images. Measurements of the esophagogastric insertion angle, gastric orientation, and volume change were obtained. Esophageal function was assessed by HRM. Number of reflux events and EGJ opening during reflux events were assessed by HRM and cine-MRI. Statistical analysis applied mixed-effects modeling. RESULTS: The esophagogastric insertion angle was wider in GERD patients than in healthy subjects (+7° ± 3°; P=0.03). EGJ opening during reflux events was greater in GERD patients than in healthy subjects (19.3 mm vs. 16.8 mm; P=0.04). The position of insertion and gastric orientation within the abdomen were also altered (both P<0.05). Median number of reflux events was 3 (95% CI: 2.5-4.6) in GERD and 2 (95% CI: 1.8-3.3) in healthy subjects (P=0.09). Lower esophageal sphincter (LES) pressure was lower (-11 ± 2 mm Hg; P<0.0001) and intra-abdominal LES length was shorter (-1.0 ± 0.3 cm, P<0.0006) in GERD patients. CONCLUSIONS: GERD patients have a wider esophagogastric insertion angle and have altered gastric morphology; structural changes that could compromise reflux protection by the "flap valve" mechanism. In addition, the EGJ opens wider during reflux in GERD patients than in healthy volunteers: an effect that facilitates volume reflux of gastric contents. More... »

PAGES

658

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ajg.2014.25

DOI

http://dx.doi.org/10.1038/ajg.2014.25

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011769699

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24589669


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28 schema:description OBJECTIVES: This study applies concurrent magnetic resonance imaging (MRI) and high-resolution manometry (HRM) to test the hypothesis that structural factors involved in reflux protection, in particular, the acute insertion angle of the esophagus into the stomach, are impaired in gastroesophageal reflux disease (GERD) patients. METHODS: A total of 24 healthy volunteers and 24 patients with mild-moderate GERD ingested a test meal. Three-dimensional models of the esophagogastric junction (EGJ) were reconstructed from MRI images. Measurements of the esophagogastric insertion angle, gastric orientation, and volume change were obtained. Esophageal function was assessed by HRM. Number of reflux events and EGJ opening during reflux events were assessed by HRM and cine-MRI. Statistical analysis applied mixed-effects modeling. RESULTS: The esophagogastric insertion angle was wider in GERD patients than in healthy subjects (+7° ± 3°; P=0.03). EGJ opening during reflux events was greater in GERD patients than in healthy subjects (19.3 mm vs. 16.8 mm; P=0.04). The position of insertion and gastric orientation within the abdomen were also altered (both P<0.05). Median number of reflux events was 3 (95% CI: 2.5-4.6) in GERD and 2 (95% CI: 1.8-3.3) in healthy subjects (P=0.09). Lower esophageal sphincter (LES) pressure was lower (-11 ± 2 mm Hg; P<0.0001) and intra-abdominal LES length was shorter (-1.0 ± 0.3 cm, P<0.0006) in GERD patients. CONCLUSIONS: GERD patients have a wider esophagogastric insertion angle and have altered gastric morphology; structural changes that could compromise reflux protection by the "flap valve" mechanism. In addition, the EGJ opens wider during reflux in GERD patients than in healthy volunteers: an effect that facilitates volume reflux of gastric contents.
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36 GERD
37 GERD patients
38 LES length
39 MRI images
40 abdomen
41 abnormal structure
42 acute insertion angle
43 addition
44 analysis
45 angle
46 changes
47 cine-MRI
48 concurrent magnetic resonance imaging
49 content
50 disease
51 disease patients
52 effect
53 esophageal function
54 esophageal sphincter pressure
55 esophagogastric insertion angle
56 esophagogastric junction
57 esophagus
58 events
59 factors
60 flap valve
61 function
62 gastric contents
63 gastric morphology
64 gastric orientation
65 gastroesophageal reflux disease
66 gastroesophageal reflux disease patients
67 healthy subjects
68 healthy volunteers
69 high-resolution manometry
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71 images
72 imaging
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75 intra-abdominal LES length
76 junctions
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78 magnetic resonance imaging
79 manometry
80 meal
81 measurements
82 mechanism
83 median number
84 mild-moderate GERD
85 mixed-effects modeling
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88 morphology
89 number
90 opening
91 orientation
92 patients
93 position
94 position of insertion
95 pressure
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97 proximal stomach
98 reflux
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102 reflux protection
103 resonance imaging
104 sphincter pressure
105 statistical analysis
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